Abstract
Benzene is used as an additive to gasoline to increase the octane and as a chemical intermediate in the synthesis of such compounds as styrene, synthetic rubber, phenol, alkylarnesulfonate detergent, nitrobenzene (aniline), and cyclohexane. The properties of benzene are shown in Table 1.
Benzene is produced at low levels in a number of biologic processes and is a component of petroleum (USEPA 1983a). Benzene is produced in large amounts, e.g., 9 billion lbs (4.08 billion kg) in 1981 (USITC 1984), and is used largely as a feedstock in the production of other chemicals. Small amounts of benzene have been used as a solvent, but this use has been discontinued. Benzene also is produced indirectly in large volumes, such as during the refining of gasoline and other operations. The average benzene content of gasoline is less than 1% (Run-ion 1975).
Based on USEPA (l983b, 1985a), except Section I, which is based on USEPA (1983a).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andrews LS, Lee EW, Witmer CM, Kocsis JJ, Snyder R (1977) Effects of toluene on the metabolism, disposition and hemopoietic toxicity of 3H-benzene. Biochem Pharmacol 26:293–300.
Beaudet BA, Keller EM, Bilello LJ, Turner RJ (Undated) Removal of specific organic contaminants from industrial wastewaters by granular-activated carbon adsorption. Incomplete citation.
Bilello LJ, Beaudet BA (1981) Evaluation of activated carbon by the dynamic mini-column adsorption technique. Incomplete citation.
Chang IW (1972) Study on the threshold limit value of benzene and early diagnosis of benzene poisoning. J Cath Med Coll 23:429.
Cummins MD (1985) Field evaluation of packed column air stripping. USEPA, Office of Drinking Water, Washington, DC.
Dean BJ (1978) Genetic toxicology of benzene, toluene, xylenes and phenols. Mut Res 47:75.
Deichmann WB, MacDonald WE, Bernal E (1963) The hemopoietic tissue toxicity of benzene vapors. Toxicol Appl Pharmacol 5:201–224.
Dobbs RJ, Cohen JM (1980) Carbon isotherms for toxic organics. EPA-600/8–80-023. USEPA Office of Research and Development, Municipal Environmental Research Laboratory, Cincinnati, OH.
Doskin TA (1971) Effect of age on the reaction to a combination of hydrocarbons. Hyg Sanit 36:379.
Forni A, Pacifico E, Limonta A (1971) Chromosome studies in workers exposed to benzene or toluene or both. Arch Environ Hlth 22:373–378.
Hough H, Freeman S (1944) Relative toxicity of commercial benzene and a mixture of benzene, toluene and xylene. Fed Proc, Fed Am Soc Exp Biol 3:20.
IARC (1982) International Agency for Research on Cancer. I ARC monographs, some industrial chemicals and dyestuffs. 29, 83, IARC, Lyon, France.
Kavanaugh MC, Trussel RR (1980) Design of aeration towers to strip volatile contaminants from drinking water. J Am Waterworks Assoc. 72(12):684–92.
Kissling M, Speck B (1969) Chromosome aberrations in experimental benzene intoxication. Helv Med Acta 36:59.
Lange AR, Smolick, Zatonski W, Syzmanska J (1973) Serum immunoglobulin levels in workers exposed to benzene, toluene and xylene. Int Arch Arbeitsmed 31:248.
Leo A, Hansch C, Elkins D (1971) Partition coefficients and their uses. Chem Rev 71(6):569.
Lonneman WA, Bellar TA, Altshuller AP (1968) Aromatic hydrocarbons in the atmosphere of the Los Angeles basin. Environ Sci Technol 2(11): 1017.
Love OT, Miltnen RJ, Eilers RG, Fronk-Leist CD (1983) Treatment of volatile organic compounds in drinking water. Report no. EPA-600/8–83-019, USEPA, Municipal Environmental Research Laboratory (MERL), Cincinnati, OH.
Maltoni C, Scartano C (1979) First experimental demonstration of the carcinogenic effects of benzene: Long term bioassays on Sprague-Dawley rats by oral administration. Med Lav 70:352–357.
Mara SJ, Lee SS (1978) Assessment of human exposures to atmospheric benzene. USEPA, Research Triangle Park, NC. Report no. EPA-450/3–78-031.
NAS (1976) National Academy of Sciences. Health effects of benzene: A review. Committee on Toxicology, Assembly of Life Sciences, National Research Council. Washington, DC.
NAS (1982) National Academy of Sciences, Drinking water and health. Vol 4. National Academy Press, Washington, DC.
NIOSH (1974) National Institute of Occupational Safety and Health. Criteria for a recommended standard-occupational exposure to benzene. PB246 700. U.S. Department of Health, Education, and Welfare (DHEW), Washington, DC.
Nomiyama K, Nomiyama H (1974a) Respiratory retention uptake and excretion of organic solvents in man. Benzene, toluene, n-hexane, trichloroethylene, acetone, ethyl acetate, and ethyl alcohol. Int Arch Arbeitsmed 32:75–83.
Nomiyama K, Nomiyama H (1974b) Respiratory elimination of organic solvents in man. Benzene, toluene, n-hexane, trichloroethylene, acetone, ethyl acetate, and ethyl alcohol. Int Arch Arbeitsmed 32:85–91.
Nylander P, Olaffsson H, Rasmuson B, Svahlin H (1978) Mutagenic effects of petrol in Drosophila melanogaster. I. Effects of benzene and 1,2-dichloroethane. Mut Res 57:163.
Olson KJ, Gehring PJ (1976) Basis for estimating acceptable levels of organic contaminants in drinking water employing inhalation data. Unpublished. Presented to National Academy of Sciences, Safe Drinking Water Committee, July 2, 1976.
OSHA (1978) Occupational Safety and Health Administration. Final environmental impact statement. Benzene. U.S. Department of Labor, Washington, DC.
OSHA (1985a) Occupational Safety and Health Administration. Toxic and Hazardous Substances. Code of Federal Regulations, 29, subpart Z, 1910.1000, Air contaminants, Table Z2. Revised July 1, 1985. Washington, DC.
OSHA (1985b) Occupational Safety and Health Administration. Occupational exposure to benzene. Proposed rule and notice of hearing. Fed Regis 50(237):50512–50517, 50540, 50528–50529, 50577–50582.
Parke DV, Williams RT (1953) Studies in detoxication. The metabolism of benzene containing 14C benzene. Biochem J 54:231–238.
Petrini M (1941) Investigations on acute and subacute poisoning by benzene. Rass Med Ind 12:435–476. (In Italian).
Pulkrabek P, Kinoshita T, Jeffery AM (1980) Benzene oxide: In vitro mutagenic and toxic effects. Proc 16th Ann Meeting Am Soc Clin Oncol 21:107.
Rickert DE, Baker TS, Bus JS, Barrow CS, Irons RD (1979) Benzene disposition in the rat after exposure by inhalation. Toxicol Appl Pharmacol 49:417–423.
Rinsky RA, Young RJ, Smith AB (1981) Leukemia in benzene workers. Am J Ind Med 2:217–245.
Runion HE (1975) Benzene in gasoline. Am Ind Hyg Assoc J 36:338–350.
Santesson CG (1897) Uber chronische Vergiftung mit steinkohlentheerbenzin; vir todes- falle. Arch Hyg Berl 31:336.
Schrenk HH, Yant WP, Pearce SJ, Patty FA, Sayers RR (1941) Absorption, distribution and elimination of benzene by body tissues and fluids of dogs exposed to benzene vapor. J Ind Hyg Toxicol 23:20–34.
Sherwood RJ (1972) Benzene: the interpretation of monitoring results. Ann Occup Hyg 15:409–421.
Smolick R, Grzybek-Hryncewica K, Lange A, Zatonski W (1973) Serum complement level in workers exposed to benzene, toluene and xylene. Int Arch Arbeitsmed 31:243.
Snyder R, Lee EW, Kocsis JJ (1978) Binding of labeled benzene metabolites to mouse liver and bone marrow. Res Commun Chem Pathol Pharmacol 20:191–194.
Synder CA, Goldstein BD, Sellakumar AR (1980) Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 ppm. J Toxicol Environ Hlth 4:605–618.
Tice RR, Costa DL, Drew RT (1980) Cytogenetic effects of inhaled benzene in murine bone marrow: Induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice. Proc Natl Acad Sci USA 77:21483152B.
Tough IM, Smith PG, Court Brown WM, Harnden DG (1970) Chromosome studies on workers exposed to atmospheric benzene: The possible influence of age. Eur J Cancer 6:49–55.
USEPA (1983a) Benzene occurrence in drinking water, food, and air. USEPA Office of Drinking Water (ODW), Washington, DC.
USEPA (1983b) Benzene draft criteria document. USEPA Office of Drinking Water (ODW), Washington, DC.
USEPA (1985a) Proposed RMCL background document for benzene for the USEPA Office of Drinking Water (ODW), Criteria and Standards Division (CSD), Washington, DC.
USEPA (1985b) Method 503.1. Volatile aromatic and unsaturated organic compounds in water by purge and trap gas chromatography. USEPA Environmental Monitoring and Support Laboratory (EMSL), Cincinnati, OH. June 1985.
USEPA (1985c) Method 524.1. Volatile organic compounds in water by purge and trap gas chromatography/mass spectrometry. USEPA Environmental Monitoring and Support Laboratory (EMSL), Cincinnati, OH. June 1985.
USEPA (1986) Guidelines for carcinogenic risk assessment. Federal Register, Washington, DC. 51 (185):33992–34003. September 24.
USEPA (1987) Benzene; Occurrence in food, water and air. Office of Drinking Water, Washington, DC.
USITC (1984) U.S. International Trade Commission. Synthetic organic chemicals, United States production, 1983. U.S. ITC Publication 1422. Washington, DC.
Von Gemert LJ, Nettenbreijer AH (1977) Compilation of odor threshold values in air and water. National Institute for Water Supply, Voorburg, Netherlands.
White WC, Gammon AM (1914) The influence of benzol inhalation on experimental pulmonary tuberculosis in rabbits. Trans Assoc Am Phys 29:332–337.
Windholz M, Budavari S, Bulmetti RF, Otterbeing ES, eds (1983) The Merck index-an encyclopedia of chemicals and drugs. 10th ed. Merck & Co Inc, Rahway, New Jersey.
Winternitz MC, Hirschfelder AD (1913) Studies on experimental pneumonia in rabbits: Parts I-III. J Exp Med 17:664.
Wolf MA, Rowe VK, McCollister DD, Hollingsworth RL, Oyen F (1956) Toxicological studies of certain alkylated benzenes and benzene. Arch Ind Hlth 14:387–389.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Ware, G.W. (1988). Benzene. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 106. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3922-2_2
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3922-2_2
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8402-4
Online ISBN: 978-1-4612-3922-2
eBook Packages: Springer Book Archive