Abstract
Hexachlorobenzene is also called HCB, HEXA C.B., and perchlorobenzene. It is not manufactured as a commercial product in the United States, but an estimated 2 to 5 million lb (0.9 to 2.3 million kg) were produced each year during the synthesis of several chlorinated chemicals as of 1979 (Mumma and Lawless 1975). Hexachlorobenzene is also an ingredient in a fungicide of which 200,000 lb (90,000 kg) were imported each year as of 1979 (IARC 1979). Its structure and properties are shown in Table 1.
HCB is a synthetic organic compound with no natural sources. HCB has been used as a fungicide, but its use has been discontinued in the U.S. HCB can occur as a contaminant in a number of chemically similar compounds that are used as pesticides (USEPA 1984a).
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References
Arnold DL (1983) Personal communication to Murial M. Lippman, ERNACO, Inc., Silver Spring, MD.
Arnold DL (1984) Personal communication to Murial M. Lippman, ERNACO, Inc., Silver Spring, MD.
Arnold DL, Moodie CA, Charbonneau SM, Grice HR, McGuire PF, Bryce FR, Collins BT, Zawidzka ZZ, Krewski DR, Nera EA, Munro IC (1985) Long-term toxicity of hexachlorobenzene in the rat and the effect of dietary vitamin A. Food Chem Toxicol 23:779–793.
Bailey J, Knauf V, Mueller W, Hobson W (1980) Transfer of hexachlorobenzene and polychlorinated biphenyls to nursing infant rhesus monkeys: Enhanced toxicity. Environ Res 21 (1): 190–196.
Cabrai JRP, Shubik P, Mollner T, Raitano F (1977) Carcinogenic activity of hexachlorobenzene in hamsters. Nature (London) 269:510–511.
Cabrai JRP, Mollner T, Raitano F, Shubik P (1979) Carcinogenesis of hexachlorobenzene in mice. Int J Cancer 23(l):47–52.
Cam C, Nigogosyan G (1963) Acquired toxic porphyria cutanea tarda due to hexachlorobenzene. JAMA 183(2): 88–91.
Courtney KD, Copeland MF, Robbins A (1976) The effects of pentachloronitrobenzene, hexachlorobenzene and related compounds of fetal development. Toxicol Appi Pharmacol 35:239–256.
Grant DL, Phillips WEJ, Hatina GV (1977) Effect of hexachlorobenzene on reproduction in the rat. Arch Environ Contam Toxicol 5(2):207–216.
Guerzoni ME, Del Cupolo L, Ponti I (1976) Mutagenic activity of pesticides (Attività mutagenica degli antiporrositari). Rev Sci Technol Alementi Nutri Um 6:161–165.
Hansen LG, Teske RH, Sundlof SM, Simon J (1979) Hexachlorobenzene and feline reproduction: effects of ground pork contaminated by dietary exposure or spiked with purified hexachlorobenzene. Vet Hum Toxicol 21(4):248–253.
I ARC (1979) International Agency for Research on Cancer. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Hexachlorobenzene. 20:155–178. IARC, Lyon, France.
Khera KS (1974) Teratogenicity and dominant lethal studies on hexachlorobenzene in rats. Food Cosmet Toxicol 12:471–477.
Kuiper-Goodman T, Grant DL, Moodie CA, Korsrud GO, Munro IC (1977) Subacute toxicity of hexachlorobenzene in the rat. Toxicol Appi Pharmacol 40(3):529–549.
Lambrecht RW, Ertuck E, Gründen EE, Peters HA, Morris CR, Bryan GT (1983a) Renal tumors in rats (R) chronically exposed to hexachlorobenzene (HCB). Proc Am Assoc Cancer Res 24:59 (Abstract).
Lambrecht RW, Ertruk E, Gründen EE, Peters HA, Morris CR, Bryan GT (1983b) Hepatocarcinogenicity of chronically administered hexachlorobenzene in rats. Fed Proc 42(4):786 (Abstract).
Lawlor T, Haworth SR, Voytek P (1979) Evaluation of the genetic activity of nine chlorinated phenols, seven chlorinated benzenes, and three chlorinated hexanes. Environ Mutagen 1:143 (Abstract).
Lu PY, Metealf RL (1975) Environmental fate and biodegradability of benzene derivatives as studied in a model aquatic ecosystem. Environ Hlth Perspec 20:269–284.
Mendoza CE, Collins BT, Shields JB, Laver GW (1978) Effects of hexachlorobenzene or hexabromobenzene on body and organ weights of pre weaning rats after a reciprocal transfer between the treated and control dams. J Agric Food Chem 26(4):941–945.
Mumma CE, Lawless EW (1975) Survey of industrial processing data. Task I—Hexachlorobenzene and hexachlorobutadiene pollution from chlorocarbon process. Prepared by Midwest Research Institute under Contract no. 68–01-2105, Report no. EPA-560/3–75-003a. NTISbpublication no. PB 243 641. NTIS, Springfield, VA.
NAS (1980) National Academy of Sciences. Drinking water and health, Vol 3. Safe Drinking Water Committee, NAS, Washington, DC. pp 210–215.
NAS (1983) National Academy of Sciences. Drinking water and health, Vol 5. Safe Drinking Water Committee, NAS, Washington, DC. pp 49–56.
Renner G (1981) Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene. Xenobiotica 11 (7): 435–446.
Rush GF, Smith JH, Maita K (1983) Perinatal hexachlorobenzene toxicity in the mink. Environ Res 31:116–124.
Sax NI (1979) Dangerous properties of industrial materials, 5th Ed. Van Nostrand Reinhold Co, NY. p 716.
Shirai T, Miyata Y, Nakanishi K, Murasaki G, Ito N (1978) Hepatocarcinogenicity of polychlorinated terphenyl (PCT) in ICR mice and its enhancement by hexachlorobenzene (HCB). Cancer Lett 4(5):271–275.
Simon GS, Tardiff RG, Borzelleca JF (1979) Failure of hexachlorobenzene to induce dominant lethal mutations in the rat. Toxicol Appl Pharmacol 47(2):415–419.
Smith AG, Cabral J (1980) Liver-cell tumors in rats fed hexachlorobenzene. Cancer Lett 11(2): 169–172.
Standard Methods (1985) Method 509A. Organochlorine Pesticides. Standard methods for the examination of water and wastewater, 16th Ed, American Waterworks Association, Denver, CO.
USEPAa (1978) Method for organochlorine pesticides in drinking water. In: Methods for organochlorine pesticides and chlorphenoxy acid herbicides in drinking water and raw source water, USEPA Environmental Monitoring Support Laboratory (EMSL), Cincinnati, OH. Interim, July 1978.
USEPAa (1980) Ambient water quality criteria for chlorinated benzenes. Report no. EPA 440/5–80-028. Environmental Criteria and Assessment Office, Cincinnati, OH. NTISbpublication no. PB 81–117392. NTIS, Springfield, VA.
USEPAa (1984a) Miscellaneous synthetic organic chemicals, occurrence in drinking water, food and air. USEPA Office of Drinking Water (ODW), Washington, DC.
USEPAa (1984b) Health assessment document for chlorinated benzenes. Report no. EPA-600/8–84-015. USEPA Office of Health and Environmental Assessment, Washington, DC.
USEPAa (1985a) Drinking water criteria document for hexachlorobenzene. ECAO- CIN-424 (final draft). USEPA Environmental Criteria and Assessment Office, Cincinnati, OH.
USEPAa (1985b) Technologies and costs for the removal of synthetic organic chemicals from potable water supplies. USEPA Science and Technology Branch, Criteria and Standards Division, Office of Drinking Water (ODW), Washington, DC.
USEPA (1986) Guidelines for carcinogenic risk assessment. Fed Regis 51(185):33992–34003. September 24.
USEPAa (1987) Hexachlorobenzene; Occurrence in food, water and air. USEPA Office of Drinking Water, Washington, DC.
WHO (1984) World Health Organization. Guidelines for drinking water quality. Vol I. Recommendations. WHO, Geneva, Switzerland, p 83.
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Ware, G.W. (1988). Hexachlorobenzene. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 106. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3922-2_13
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