Abstract
The archetypical radial glial cell, the retinal Müller cell has been considered to be a “primitive” form of glia (Cajal, 1892). Nevertheless the Müller cell is a highly specialized cell type whose form and function have been apparently conserved throughout vertebrate evolution. All sighted vertebrates ranging from cyclostomes to man possess Müller cells with strikingly similar structure and common biochemical characteristics (Hueter et al, 1986; Linser and Moscona, 1984a). Discovering the roles performed by these glial cells will lead to understanding of fundamental principles in retina function. Also, since it is widely believed that radial glia play formative roles in the development of form and function throughout the vertebrate nervous system, developmental analyses of Müller cells will also aid our understanding of neural development in general.
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Linser, P.J. (1988). Plasticity of Retinal Glioblast Cells: Neuronal Contact Regulates Phenotypic Maturation of Embryonic Müller Cells. In: Hilfer, S.R., Sheffield, J.B. (eds) Cell Interactions in Visual Development. Cell and Developmental Biology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3920-8_3
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DOI: https://doi.org/10.1007/978-1-4612-3920-8_3
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