Skip to main content
SpringerLink
Log in

Carmustine (BCNU) in Silicone Oil Prevents Proliferation of Cultured Cells

  • Chapter
Proliferative Vitreoretinopathy (PVR)

  • 63 Accesses

Abstract

In proliferative vitreoretinopathy (PVR), unwanted cellular growth may occur under or over the retina following retinal detachment surgery or penetrating injury to the eye, and this often leads to unsuccessful surgery.1 Meticulous membrane removal with the adjunctive use of silicone oil for prolonged tamponade has increased surgical success rates2,3; however, PVR may recur despite this surgical modality.4

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ryan SJ. The pathophysiology of proliferative vitreo-retinopathy in its management. Am J Ophthalmol 1985; 100:188–193.

    PubMed  CAS  Google Scholar 

  2. Grey HB, Leaver PK. Silicone oil in the treatment of massive preretinal retraction. I. Results in 105 eyes. Br J Ophthalmol 1979; 63:355–360.

    Article  PubMed  CAS  Google Scholar 

  3. Gonvers M. Temporary silicone oil tamponade in the management of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol 1985; 100:239–245.

    PubMed  CAS  Google Scholar 

  4. Glaser BM. Treatment of giant retinal tears combined with proliferative vitreoretinopathy. Ophthalmology 1986;93:1193–1197.

    PubMed  CAS  Google Scholar 

  5. Litin BS, Jones MA, Kwong EM, Herschier J. Effect of antineoplastic drugs on cell proliferation-individually and in combination. Ophthalmic Surg 1985; 16:34–39.

    PubMed  CAS  Google Scholar 

  6. Fiscella R, Elvart J, Peyman GA, Yue B. In vitro evaluation of cellular inhibitory potential of various antineoplastic drugs and dexamethasone. Ophthalmic Surg 1985; 16:247–249.

    PubMed  CAS  Google Scholar 

  7. Blumenkrantz MS, Harter MK, Hajek AS. Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines. Arch Ophthalmol 1987; 105:396–399.

    Google Scholar 

  8. Stern WH, Lewis GP, Erickson PA, et al. Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. Am J Ophthalmol 1983; 96:33–42.

    PubMed  CAS  Google Scholar 

  9. DeVita VT, Denham C, Davidson JD, Oliverio VT. The physiological disposition of the carcinostatic l,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) in man and animals. Clin Pharm Ther 1967; 8:566–577.

    CAS  Google Scholar 

  10. Loo TL, Dion RL. Colorimetric method for the determination of l,3-bis(2-chloroethyl)-1-nitrosourea. J Pharm Sci 1965; 54:809–810.

    Article  PubMed  CAS  Google Scholar 

  11. Tresher RJ, Ehrenberg M, Machemer R. Gasmediated gas compression: an experimental alternative to mechanized vitrectomy. Graefes Arch Clin Exp Ophthalmol 1984; 221:192–198.

    Article  Google Scholar 

  12. Lambrou FH, Burke JM, Arberg TM. Silicone oil enhances proliferation in experimental proliferative vitreo-retinopathy. Invest Ophthalmol Vis Sci 1987; 28(Suppl):290.

    Google Scholar 

  13. Miller DF, Bay JW, Lederman RJ, et al. Ocular and orbital toxicity following intracarotid injection of BCNU (carmustine) and cisplatinum for malignant gliomas. Ophthalmology 1985; 92:402–406.

    PubMed  CAS  Google Scholar 

  14. Liu HS, Perry HD, Refojo MF. Tolerance of normal rabbit eyes to the antineoplastic carmustine. Ophthalmologica 1980; 181:41–46.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Felipe I. Tolentino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Victorio N. Cajita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hum Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Norio Ueno
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Miguel F. Refojo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, Boston, Massachusetts, 02114, USA

    H. MacKenzie Freeman MD (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) & Felipe I. Tolentino MD (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director) (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) &  (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director)

  2. Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, 02114, USA

    H. MacKenzie Freeman MD (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) & Felipe I. Tolentino MD (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director) (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) &  (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director)

  3. Ophthalmic Microsurgery Laboratory, Eye Research Institute of Retina Foundation, Boston, Massachusetts, 02114, USA

    H. MacKenzie Freeman MD (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) & Felipe I. Tolentino MD (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director) (Associate Clinical Professor of Ophthalmology, Surgeon in Ophthalmology, Senior Clinical Scientist) &  (Associate Clinical Professor of Ophthalmology, Associate Surgeon in Ophthalmology, Program Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Tolentino, F.I., Cajita, V.N., Chung, H., Ueno, N., Refojo, M.F. (1988). Carmustine (BCNU) in Silicone Oil Prevents Proliferation of Cultured Cells. In: Freeman, H.M., Tolentino, F.I. (eds) Proliferative Vitreoretinopathy (PVR). Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3910-9_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3910-9_23

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8398-0

  • Online ISBN: 978-1-4612-3910-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation