PVR: An Overview

  • Carl Claes
  • H. MacKenzie Freeman
  • Felipe I. Tolentino

Abstract

Proliferative vitreoretinopathy (PVR) is the most common cause of failure of rhegmatogenous retinal detachment surgery.1–5 PVR is used to describe a condition which was formerly called massive vitreous retraction (MVR),6–8 massive preretinal retraction (MPR),9 and massive preretinal proliferation (MPP).10 The new terminology, PVR, was introduced by the Retina Society to reflect the clinical findings based on ophthalmoscopic and biomicroscopic examination, and the pathologic changes based on histopathologic findings of cellular proliferation in the vitreous and retina.1 Although the term PVR seems appropriate, the classification system is incomplete because it did not include the anterior vitreoretinal changes and the subretinal pathology characterized by sub-retinal membranes.7,11–13

Keywords

Migration Shrinkage Retina Immobilization Flare 

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References

  1. 1.
    The Retina Society Terminology Committee: The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology 1983;90:121–125.Google Scholar
  2. 2.
    Rachal WF, Burton TC. Changing concepts of failure after retinal detachment surgery. Arch Ophthalmol 1979;97:480–483.PubMedGoogle Scholar
  3. 3.
    Hilton GF. Subretinal pigment migration: Effects of cryosurgical reattachment. Arch Ophthalmol 1974;91:445.PubMedGoogle Scholar
  4. 4.
    Charles S. Vitrectomy for retinal detachment. Trans Ophthalmol Soc UK 1980;100:542–549.PubMedGoogle Scholar
  5. 5.
    The Silicone Study Group. Proliferative vitreoretinopathy (editorial). Am J Ophthalmol 1985;99:593–595.Google Scholar
  6. 6.
    Hruby K. Massive vitreous retraction. Doc Ophthalmol 1969;26:555–565.PubMedCrossRefGoogle Scholar
  7. 7.
    Scott JD. The treatment of massive vitreous retraction. Trans Ophthalmol Soc UK 1973;93:417–423.PubMedGoogle Scholar
  8. 8.
    Havener WH. Massive vitreous retraction. Int Ophthalmol Clin 1976;16:135–155.PubMedCrossRefGoogle Scholar
  9. 9.
    Cibis PA. Recent methods in the surgical treatment of retinal detachment: Intravitreal procedures. Trans Ophthalmol Soc UK 1965;85:111–127.PubMedGoogle Scholar
  10. 10.
    Tolentino FI, Schepens CL, Freeman HM. Massive preretinal proliferation: A biomicroscopic study. Arch Ophthalmol 1967;78:16.PubMedGoogle Scholar
  11. 11.
    Schepens CL. Proliferative vitreoretinopathy (PVR) (letter). Ophthalmology 1987;94:201.PubMedGoogle Scholar
  12. 12.
    Freeman HM. Anterior Proliferative Vitreoretinopathy. In Jaffe NS (ed.), Atlas of Ophthalmic Surgery. New York: Gower (in press).Google Scholar
  13. 13.
    Lewis H, Aaberg T. Anterior proliferative vitreoretinopathy. Am J Ophthalmol 1988;105:277.PubMedCrossRefGoogle Scholar
  14. 14.
    Havener WH. Massive vitreous retraction. Ophthalmic Surg 1973;4:122–167.Google Scholar
  15. 15.
    Scott JD. The treatment of massive vitreous retraction by the separation of preretinal membranes using liquid silicone. Mod Probi Ophthalmol 1975;15:285–290.Google Scholar
  16. 16.
    Machemer R. Pathogenesis and classification of massive periretinal proliferation. Br J Ophthalmol 1978;62:737–747.PubMedCrossRefGoogle Scholar
  17. 17.
    Ryan SJ. The pathophysiology of proliferative vitreoretinopathy in its management. Am J Ophthalmol 1985;100:188–193.PubMedGoogle Scholar
  18. 18.
    Stilma JS, Koster R, Živojnović R. Radical vitrectomy and silicone oil injection in the treatment of proliferative vitreoretinopathy following retinal detachment. Doc Ophthalmol 1986;64:109–116.PubMedCrossRefGoogle Scholar
  19. 19.
    Michels RG. Surgery of retinal detachment with PVR. Retina 1984;4:63–83.PubMedCrossRefGoogle Scholar
  20. 20.
    Schepens CL. Retinal Detachment and Allied Diseases. Philadelphia: WB Saunders, 1983, pp. 929–930.Google Scholar
  21. 21.
    Hirose T, Schepens CL, Lopansri C. Subtotal open sky vitrectomy for severe retinal detachment occurring as a late complication of ocular trauma. Ophthalmology 1981;88:1–9.PubMedGoogle Scholar
  22. 22.
    Charles S. Vitreous surgery for periretinal proliferation. In Jakobiec FA, Sigelman J (eds.), Advanced Techniques in Ocular Surgery. Philadelphia: WB Saunders, 1984, pp. 295.Google Scholar
  23. 23.
    Schepens CL. Retinal Detachment and Allied Diseases. Philadelphia: WB Saunders, 1983, p. 197.Google Scholar
  24. 24.
    Tolentino FI, Schepens CL, Freeman HM. Vitreoretinal Disorders: Diagnosis and Management. Philadelphia: WB Saunders, 1976, p. 480.Google Scholar
  25. 25.
    Miglior S, Kain HL, Libondi T, et al. Early vitreous changes in experimental proliferative vitreoretinopathy. Arch Ophthalmol 1986;104:1681–1684.PubMedGoogle Scholar
  26. 26.
    Cangemi FE, Pitta CG, Schwartz PL. Spontaneous resolution of massive periretinal proliferation. Am J Ophthalmol 1982;93:92–95.PubMedGoogle Scholar
  27. 27.
    Barrada A, Peyman GA, Case J, et al. Evaluation of intravitreal 5-fluorouracil, vincristine, VP 16, doxorubicin, and thiotepa in primate eyes. Ophthalmic Surg 1984;15:767–769.PubMedGoogle Scholar
  28. 28.
    Byer NE. Spontaneous disappearance of early postoperative preretinal retraction: a sequel of retinal detachment surgery. Arch Ophthalmol 1973;90:133–135.PubMedGoogle Scholar
  29. 29.
    Tornambe PE. The arrest of massive periretinal proliferation. A case report. Retina 1981;1:208–210.PubMedCrossRefGoogle Scholar
  30. 30.
    Samuels B. Pathological picture of retinal detachment: A survey. Arch Ophthalmol 1939;21:273–314.Google Scholar
  31. 31.
    Gonin J. Le Décollement de la Rétine: Pathogénie-Traitement. Lausanne: Payot et Cie, 1934.Google Scholar
  32. 32.
    Lindner K. Zur Klinik des Glaskörpers: III. Glaskörper und Netzhautabhebung. Arch für Ophthalmol 1937;137:157–202.CrossRefGoogle Scholar
  33. 33.
    Kampik A, Kenyon KR, Michels RG, et al. Epiretinal and vitreous membranes: Comparative study of 56 cases. Arch Ophthalmol 1981;99:1445–1454.PubMedGoogle Scholar
  34. 34.
    Yamashita H, Hori S, Kitano S, et al. Glial cells in culture of preretinal membrane of proliferative vitreoretinopathy. Jpn J Ophthalmol 1985;29:42–53.PubMedGoogle Scholar
  35. 35.
    Van Horn DL, Aaberg TM, Machemer R, Fenzl R. Glial cells proliferation in human retinal detachment with massive periretinal proliferation. Am J Ophthalmol 1977;84:383–393.PubMedGoogle Scholar
  36. 36.
    Roth AM, Foos RY. Surface structure of the optic nerve head. 1. Epipapillary membranes. Am J Ophthalmol 1972;74:977–985.PubMedGoogle Scholar
  37. 37.
    Laqua H, Machemer R. Clinical-pathological correlation in massive periretinal proliferation. Am J Ophthalmol 1975;80:913–929.PubMedGoogle Scholar
  38. 38.
    Kenyon KR, Michels RG. Ultrastructure of epiretinal membrane removed by pars plana vitreoretinal surgery. Am J Ophthalmol 1977;83:815–823.PubMedGoogle Scholar
  39. 39.
    Kenyon KR, Pederson JE, Green WR, Maumenee AE. Fibroglial proliferation in pars planitis. Trans Ophthalmol Soc UK 1975;95:391–397.PubMedGoogle Scholar
  40. 40.
    Foos RY. Vitreoretinal juncture: Simple epiretinal membranes. Graefes Arch Klin Ophthalmol 1974; 189:231–250.CrossRefGoogle Scholar
  41. 41.
    Clarkson JG, Green WR, Massof D. A histopathological review of 168 cases of preretinal membrane. Am J Ophthalmol 1977;84:1–17.PubMedGoogle Scholar
  42. 42.
    Bellhorn RW, Friedman AH, Wise GN, Hendkind P. Ultrastructure and clinicopathologic correlation of idiopathic preretinal macular fibrosis. Am J Ophthalmol 1975;79:366–373.PubMedGoogle Scholar
  43. 43.
    Wallow IHL, Miller SA. Preretinal membrane by retinal pigment epithelium. Arch Ophthalmol 1978;96:1643–1646.PubMedGoogle Scholar
  44. 44.
    Smith RS, van Heuven WAJ, Streeten B. Vitreous membranes: A light and electron microscopical study. Arch Ophthalmol 1976;95:1556–1560.Google Scholar
  45. 45.
    Laqua H, Machemer R. Clinical-pathological correlation in massive periretinal proliferation. Am J Ophthalmol 1975;80:913–929.PubMedGoogle Scholar
  46. 46.
    Machemer R, Laqua H. Pigment epithelium proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol 1975;80:1–23.PubMedGoogle Scholar
  47. 47.
    Wallyn RH, Hilton GF. Subretinal fibrosis in retinal detachment. Arch Ophthalmol 1979;97:2128–2129.PubMedGoogle Scholar
  48. 48.
    Sternberg P, Machemer R. Subretinal proliferation. Am J Ophthalmol 1984;98:456–462.PubMedCrossRefGoogle Scholar
  49. 49.
    Wilkes SR, Mansour AM, Green WR. Proliferative vitreoretinopathy. Histopathology of retroretinal membranes. Retina 1987;7:94–101.PubMedCrossRefGoogle Scholar
  50. 50.
    Machemer R. Discussion of presentation by Federman JL, Folberg R, Ridley M, Arbiso VA. Subretinal cellular bands. Trans Am Ophthalmol Soc 1983;81:172–181.Google Scholar
  51. 51.
    Newsome DH, Rodriguez MM, Machemer R. Human massive periretinal proliferation in vitro characteristics in cellular components. Arch Ophthalmol 1981;99:873–880.PubMedGoogle Scholar
  52. 52.
    Machemer R, Van Horn D, Aaberg TM. Pigment epithelial proliferation in human retinal detachment with massive preretinal retraction. Am J Ophthalmol 1978;85:181–191.PubMedGoogle Scholar
  53. 53.
    Mandelcorn MS, Machemer R, Fineberg E, et al. Proliferation and metaplasia of intravitreal retinal pigment epithelial cell autotransplants. Am J Ophthalmol 1975;80:227–237.PubMedGoogle Scholar
  54. 54.
    Meuller-Jenson K, Machemer R, Azarnia R. Auto transplantation of retinal pigment epithelium in intravitreal diffusion chamber. Am J Ophthalmol 1975;80(3 Part II):531–537.Google Scholar
  55. 55.
    Cibis PA. Vitreous transfer and silicone injections. Trans Am Acad Ophthalmol 1969;68:983–987.Google Scholar
  56. 56.
    Wiedemann P, Heimann K. Proliferative vitreoretinopathy. Pathogenesis and possibilities for treatment with cytostatic drugs. Klin Monatsbl Augenheilkd 1986;188:559–564.PubMedCrossRefGoogle Scholar
  57. 57.
    Font RL, Green WR, Howes EL, et al. Ophthalmic Pathology, Volume 2, An Atlas and Textbook. Philadelphia: WB Saunders, 1985, p. 711.Google Scholar
  58. 58.
    Font RL, Green WR, Howes EL, et al. Ophthalmic Pathology, Volume 2, An Atlas and Textbook. Philadelphia: WB Saunders, 1985, p. 719.Google Scholar
  59. 59.
    Roth AM, Foos RY. Surface wrinkling retinopathy in eyes enucleated at autopsy. Trans Am Acad Ophthalmol Otolaryngol 1971;75:1047–1058.PubMedGoogle Scholar
  60. 60.
    Fisher JP, Lewis LM, Blumenkranz M, et al. The acute retinal necrosis syndrome. Part I: clinical manifestations. Ophthalmology 1982;89:1309–1316.PubMedGoogle Scholar
  61. 61.
    Kampik A, Green WR, Michels RG, Rice TA. Epiretinale Membranen nach Photokoagulation (postkoagulative Maculopathie). Ber Dtsch Ophthalmol Ges 1981;78:593–598.Google Scholar
  62. 62.
    Campochiaro PA, Bryan JA, Conway BP, Jaccoma EH. Intravitreous chemotactic and mitogenic activity. Implication of blood-retinal barrier breakdown. Arch Ophthalmol 1986;104:1685–1687.PubMedGoogle Scholar
  63. 63.
    Vidaurri-Leal J, Hohman R, Glaser GM. Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells. A new approach to the study of proliferative vitreoretinopathy. Arch Ophthalmol 1984;102:1220–1223.PubMedGoogle Scholar
  64. 64.
    Wiedemann P, Ryan SJ, Novak P, Sorgente N. Vitreous stimulates proliferation of fibroblasts and retinal pigment epithelial cells. Exp Eye Res 1985;41:619–628.PubMedCrossRefGoogle Scholar
  65. 65.
    Campochiaro PA, Jerdan JA, Glaser BM. Serum contains chemoattractants for human retinal pigment epithelial cells. Arch Ophthalmol 1984; 102:1830–1833.PubMedGoogle Scholar
  66. 66.
    Campochiaro PA, Glaser BM. Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells. Arch Ophthalmol 1985;103:576–579.PubMedGoogle Scholar
  67. 67.
    Campochiaro PA, Jerdan JA, Glaser BM, et al. Vitreous aspirates from patients with proliferative vitreoretinopathy stimulate retinal pigment epithelial cell migration. Arch Ophthalmol 1985; 103: 1403–1405.PubMedGoogle Scholar
  68. 68.
    Bryan JA, Campochiaro PA. Pars plana vitrectomy and intravitreal silicone oil injection in eyes with rubeosis iridis. Can J Ophthalmol 1986;21:10–12.Google Scholar
  69. 69.
    Singh AK, Glaser BM, Lemor M, Michels RG. Gravity-dependent distribution of retinal pigment epithelial cells dispersed into the vitreous cavity. Retina 1986;6:77–80.PubMedGoogle Scholar
  70. 70.
    Glaser BM, Cardin A, Biscoe B. Proliferative vitreoretinopathy. The mechanism of development of vitreoretinal traction. Ophthalmology 1987;94:327–332.PubMedGoogle Scholar
  71. 71.
    Yoshizumi MO, Kreiger AE, Sharp DM. Risk factors associated with the development of massive preretinal proliferation. In Ryan S (ed.), Retinal Diseases. New York, Grune & Stratton, 1985.Google Scholar
  72. 72.
    Bonnet M. Clinical factors predisposing to massive proliferative vitreoretinopathy in rhegmatogenous retinal detachment. Ophthalmologica 1984;188:148–152.PubMedCrossRefGoogle Scholar
  73. 73.
    Singh AK, Michels RG, Glaser BM. Scleral indentation following cryotherapy and repeat cryotherapy enhance release of viable retinal pigment epithelial cells. Retina 1986;6:176–178.PubMedGoogle Scholar
  74. 74.
    Campochiaro PA, Kaden IH, Vidaurri-Leal J, Glaser BM. Arch Ophthalmol 1985;103:434–436.PubMedGoogle Scholar
  75. 75.
    Machemer R. Massive periretinal proliferation: A logical approach to therapy. Trans Am Ophthalmol Soc 1977;75:556–586.PubMedGoogle Scholar
  76. 76.
    Yoshizumi MO, Kreiger AF, Sharp DM. Massive periretinal proliferation following prophylactic treatment of retinal breaks. Trans Ophthalmol Soc NZ 1983;35:33–36.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Carl Claes
  • H. MacKenzie Freeman
  • Felipe I. Tolentino

There are no affiliations available

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