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Abstract

Disease: Infectious mononucleosis (IM), Burkitt’s lymphoma (BL), undifferentiated nasopharyngeal carcinoma (NPC).

Etiologic Agent: Epstein-Barr virus—etiologic in IM; cofactor in BL and NPC.

Source: Human saliva and blood.

Clinical Manifestations: Acute or insidious onset with fever, pharyngitis, lymphadenopathy. May be associated with varying degrees of splenomegaly, hepatomegaly, or frank hepatitis. Rare central nervous system involvement.

Pathology: Marked lymphocytosis involving most of the lymphoreticular tissues; hematologic abnormalities include >10,000 lymphocytes/ml with >10 to 15% atypical lymphocytes; elevated liver enzymes.

Laboratory Diagnosis: Positive Paul-Bunnell heterophile antibodies within the first 4 weeks of illness in adolescent and older patients. EBV serology may be needed for hetero- phile-negative patients; EBV isolation not useful.

Epidemiology: Worldwide; infections mostly asymptomatic in children; morbidity in-creases with age of primary infection; infections occur in children younger than 5 years of age in lower socioeconomic communities; acute disease is mostly sporadic with no seasonal variation among older patients in more affluent communities.

Treatment: Anecdotal report of efficacy with acyclovir and its derivatives. Prevention and Control: Avoidance of salivary exchange.

Keywords

Infectious Mononucleosis Heterophile Antibody Lymphoblastoid Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Evelyne T. Lennette

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