Filariasis

  • D. O. Freedman
  • T. B. Nutman

Abstract

The filariases are vectorborne human parasitic diseases with a complex life cycle; they are caused by nematodes, which, in their mature stage, reside in the lymphatic system or in the connective tissue. Although the adult parasite itself may provoke impressive and chronic inflammatory reactions in tissues, it can live for years or decades continuously producing huge numbers of larvae. These larvae, called microfilariae, can themselves cause significant, debilitating, and long-term chronic pathology.

Keywords

Malaria Glaucoma Dermatitis Uveitis Mast 

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Literature Cited

  1. Abaru, D. E., and D. A. Denham. 1976. A comparison of the efficacy of the Nuclepore and Millipore filtration systems for detecting microfilariae. Southeast Asian J. Trop. Med. Public Health 7:367–369.PubMedGoogle Scholar
  2. Adolph, P. E., I. G. Kagan, and R. M. McQuay. 1962. Diagnosis and treatment of Acanthocheilonema perstans filariasis. Am. J. Trop. Med. Hyg. 11:76–88.PubMedGoogle Scholar
  3. Ambroise-Thomas, P., and F. Peyron. 1986. Filariasis, p. 233–256. In K. W. Walls and P. M. Shantz (ed.), Immunodiagnosis of parasitic diseases, vol. 1. Academic Press, Inc., New York.Google Scholar
  4. Buck, A. A. 1973. Microfilariae in onchocerciasis in Africans. Z. Tropenmed. Parasitol. 24:336–338.Google Scholar
  5. Buck, A. A. (ed.). 1974. Onchocerciasis, symptomatology, pathology, and diagnosis, p. 9–14. World Health Organization, Geneva.Google Scholar
  6. Dissanaike, A. S.1979. Zoonotic aspects of filarial infection in man. Bull. W.H.O. 57:349–357PubMedGoogle Scholar
  7. Greene, B. M., H. R. Taylor, E. W. Cupp, R. P. Murphy, A. T. White, M. A. Aziz, et al. 1985. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. N. Engl. J. Med. 313:133–138.PubMedCrossRefGoogle Scholar
  8. Hamilton, P. G. 1985. Application of immunoassay methods in the serodiagnosis of human filariasis. Rev. Infect. Dis. 7:837–843.PubMedCrossRefGoogle Scholar
  9. Hawking, F. 1979. Diethylcarbamazine and new compounds for the treatment of filariasis. Adv. Pharmacol. Chemother. 16:129–194.PubMedCrossRefGoogle Scholar
  10. Hira, P. R. 1977. Wuchereria bancrofti: the staining of the microfilarial sheath in Giemsa and haematoxylin for diagnosis. Med. J. Zambia 11:93–96.PubMedGoogle Scholar
  11. Knott, J. I. 1939. A method for making microfilarial surveys in day blood. Trans. R. Soc. Trop. Med. Hyg. 33:191–196.CrossRefGoogle Scholar
  12. McMahon, J. E. 1982. The examination time/dose interval in the provocation of nocturnally periodic microfilariae of Wuchereria bancrofti with diethylcarbamazine and practical uses of the test. Tropenmed. Parasitol. 33:28–30.PubMedGoogle Scholar
  13. McQuay, R. M. 1970. Citrate saponin acid method for the recovery of microfilariae from blood. Am. J. Clin. Pathol. 54:743–746.PubMedGoogle Scholar
  14. Meyers, W. M., D. H. Connor, L. E. Harman, K. Fleshman, R. Moris, and R. C. Neafie. 1972. Human streptocerciasis. A clinicopathologic study of 40 Africans including identification of the adult filaria. Am. J. Trop. Med. Hyg. 21:528–545.PubMedGoogle Scholar
  15. Nathan, M. B. 1979. A comparison of Mansonella ozzardi microfilaria densities in the blood and in skin snips from three areas of the body. Trans. R. Soc. Trop. Med. Hyg. 73:338–340.PubMedCrossRefGoogle Scholar
  16. Nutman, T. B., K. D. Miller, M. Mulligan, and E. A. Ottesen. 1986. Loa loa infection in temporary residents of endemic regions: recognition of a hyperresponsive syndrome with characteristic clinical manifestations J. Infect. Dis. 154:10–18CrossRefGoogle Scholar
  17. Ottesen, E. A. 1985. Efficacy of diethylcarbamazine in eradication of infection with the lymphatic dwelling filariae of humans. Rev. Infect. Dis. 7:341–356.PubMedCrossRefGoogle Scholar
  18. Sasa, M. 1976. Human filariasis: a global survey of epidemiology and control. University Park Press, Baltimore.Google Scholar
  19. Wartman, W. B., and B. G. King. 1947. Filariasis in American armed forces in WWII. Medicine (Baltimore) 26:334–394.Google Scholar
  20. W.H.O. Fourth Expert Committee on Lymphatic Filariasis. 1984. World Health Organization technical report series no. 702. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • D. O. Freedman
  • T. B. Nutman

There are no affiliations available

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