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Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 105))

Abstract

Aldicarb (2-methyl-2[methylthio]propionaldehyde 0-[methyl carbamoyl]-oxime; TEMIK®, Rhone-Poilenc’s registered trademark) effectively controls a wide variety of insects, mites, and nematodes and is used worldwide on more than 40 economically important crops. Aldicarb is a potent acetylcholinesterase inhibitor and is commercially available only in granular formulations containing 5% to 10% active ingredient. As formulated, the potential hazard of aldicarb to human health and to the environment is sinificantly reduced.

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References

  • Abdalla NA (1980) TEMIK aldicarb pesticide. Volunteer workers’ exposure monitoring study, Puerto Armuelles, Panama, September, 1979. Union Carbide Agricultural Products, Inc. (unpublished).

    Google Scholar 

  • Ackerman JK (1971) Observations of insects and other inhabitants of the higher fungi, especially wood-rotting types, in Wisconsin. Diss Abstr Int 32:3414B–3415B.

    Google Scholar 

  • Aldridge D, Schardein JL, Blair M (1983) Aldicarb. Range-finding teratology study in rabbits. International Research and Development Corp Report No. 369-106 (unpublished).

    Google Scholar 

  • Aldridge WN (1971) The nature of the reaction of organophosphorus compounds and carbamates with esterases. Bull WHO 44:25–30.

    PubMed  CAS  Google Scholar 

  • Anderson LD, Atkins EL Jr. (1966) Field tests on the effect of pesticides on honey bees. Department of Entomology, University of California at Riverside (unpublished).

    Google Scholar 

  • Andrawes NR (1977) The metabolism of (UC 21875) sulfocarb pesticide in the rat. Union Carbide Agricultural Products Co, Inc., File No. 23188 (unpublished).

    Google Scholar 

  • Andrawes NR (1982) Evaluation of excretion of aldicarb and its metabolites in laboratory animals and humans. Union Carbide Agricultural Products Co, Inc., File No. 30566 (unpublished).

    Google Scholar 

  • Andrawes NR, Bagley WP, Herrett RA (1971) Metabolism of 2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)oxime (TEMIK® aldicarb pesticide) in potato plants. J Agric Food Chem 19:731–737.

    PubMed  CAS  Google Scholar 

  • Andrawes NR, Dorough HW, Lindquist DA (1967) Degradation and elimination of TEMIK in rats. J Econ Entomol 60:979–987.

    PubMed  CAS  Google Scholar 

  • Andrewes NR, Lee RE (1986) TEMIK® brand aldicarb pesticide. Aldicarb metabolism in lactating goats. Union Carbide Agricultural Products Co, Inc., File No. 34558 (unpublished).

    Google Scholar 

  • Atkins EL Jr (1970) Toxicity of pesticide and other agricultural chemicals to honey bees. Laboratory studies. University of California at Riverside, Agricultural Extension Monograph M-16.

    Google Scholar 

  • Atkins EL Jr, Greywood EA, MacDonald RL (1972) Effect of pesticides on apiculture. Department of Entomology, University of California at Riverside, Ann Report, Project No. 1499 (unpublished).

    Google Scholar 

  • Atkins EL Jr, Kellum D, Atkins KW (1981) Reducing pesticide hazards to honey bees:mortality prediction techniques and integrated management strategies. University of California at Riverside, Leaflet No. 2883.

    Google Scholar 

  • Atkins EL Jr, Kellum D, Newman KJ, MacDonald RL, Ferguson DT (1975) Effects of pesticides on apiculture. Department of Entomology, University of California at Riverside, Ann Report, Project No. 1499 (unpublished).

    Google Scholar 

  • Babish JG, Salerno A (1977) Neurotoxicity evaluation of UC 21865 in White Leghorn hens (Gallus domesticus). Food and Drug Research Laboratories, Inc., Report No. 5233 (unpublished).

    Google Scholar 

  • Back RC (1968) TEMIK® 10G granular pesticide. Field evaluation of potential hazard to bobwhite quail. Union Carbide Agricultural Products Company, Inc., Report No. 49-29 (unpublished).

    Google Scholar 

  • Back RC (1979) Letter of 10 May to Mr. Clayton Bushong, Chief, Ecological Effects Branch, Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington. Union Carbide Agricultural Products Company, Inc. (unpublished).

    Google Scholar 

  • Balcomb R (1980) Granular pesticide, restricted classification based on the hazard to avian wildlife. Ecological Effects Branch, Office of Pesticide Programs, U.S. Environmental Protection Agency (unpublished).

    Google Scholar 

  • Balcomb R, Stevens R, Bowen C II (1984) Toxicity of 16 granular insecticides to wild-caught songbirds. Bull Environ Contam Toxicol 33:302–307.

    PubMed  CAS  Google Scholar 

  • Bartley WJ, Andrawes NR, Chancey EL, Bagley WP, Spurr HW (1970) Metabolism of TEMIK aldicarb pesticide [2-methyl-2-(methylthio)propionaldehyde O-(methyl-carbamoyl)oxime] in the cotton plant. J Agric Food Chem 18:446–453.

    PubMed  CAS  Google Scholar 

  • Beavers JB, Fink R (1979) Eight-day dietary LC50-bobwhite quail. Technical grade aldicarb. Final report. Wildlife International Ltd. Report No. 142-118 (unpublished).

    Google Scholar 

  • Beliles RP, Knott W, Wright L (1966) UC 21149. Safety evaluation on fish and wildlife (bobwhite quail and rainbow trout). Woodard Research Corp Report (unpublished).

    Google Scholar 

  • Benjamini L (1981a) Testing aldicarb as a bird repellent in a sprouting sugar beet field. Phytoparasitica 9:89–94.

    CAS  Google Scholar 

  • Benjamini L (1981b) The effect of high-level bird-repellent treatment with aldicarb on the germination and development of sugar beets. Phytoparasitica 9:11–17.

    CAS  Google Scholar 

  • Benjamini L (1981c) The efficacy of seed treatment with aldicarb to establish conditioned aversion in birds to sprouting sugar beets. Phytoparasitica 9:3–9.

    CAS  Google Scholar 

  • Blevins RD, Lijinsky W, Ragan JD (1977) Nitrosated methylcarbamate insecticides: effect on the DNA of human cells. Mutat Res 44:1–7.

    PubMed  CAS  Google Scholar 

  • Bocanegra J (1982) Summary of Schuster’s data on beneficials. Letter of 5 March, Union Carbide Agricultural Products Co, Inc. (unpublished).

    Google Scholar 

  • Borash AJ (1965) Test report on UC 21149 and the goldfish Carassius auratus. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Brown PM, Bunyan PJ, Stanley PI, van den Heuvel MJ (1975) Field surveillance of the possible wildlife hazards associated with the use of the nematicide, aldicarb. U.K. Ministry of Agriculture, Fisheries, and Food, Chemistry Department Report No. 17.

    Google Scholar 

  • Bull DL, Lindquist DA, Coppedge JR (1967) Metabolism of 2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)oxime (TEMIK, UC 21149) in insects. J Agric Food Chem 15:610–616.

    CAS  Google Scholar 

  • Bunyan PJ, van den Heuvel MJ, Stanley PI, Wright EN (1981) An intensive field trial and a multi-site surveillance exercise on the use of aldicarb to investigate methods for the assessment of possible environmental hazards presented by new pesticides. Agro-Ecosystems 7:239–262.

    CAS  Google Scholar 

  • Burrows IE, Haynes G, Roberts N (1970) Determination of exposure levels in operations to TEMIK during field trials. Huntingdon Research Centre Report No. 3575/70/387 (unpublished).

    Google Scholar 

  • Cambon C, Declume C, Derache R (1979) Effect of the insecticidal carbamate derivatives (carbofuran, pirimicarb, aldicarb) on the activity of acetylcholinesterase in tissues from pregnant rats and fetuses. Toxicol Appl Pharmacol 49:203–208.

    PubMed  CAS  Google Scholar 

  • Cambon C, Declume C, Derache R (1980) Foetal and maternal rat brain acetylcholinesterase: isoenzymes changes following insecticidal carbamate derivatives poisoning. Arch Toxicol 45:257–262.

    PubMed  CAS  Google Scholar 

  • Carpenter CP (1969) Miscellaneous toxicity studies. Mellon Institute Report No. 32-84 (unpublished).

    Google Scholar 

  • Carpenter CP, Smyth HF (1966) TEMIK 10G (10.5% granular formulation of compound 21149). 15-day dermal applications to rabbits. Mellon Institute Report No. 29-80 (unpublished).

    Google Scholar 

  • Chin GH, Sullivan LJ (1968) Some biochemical considerations of TEMIK pesticide. Presented at the 156th national meeting of the Am Chem Soc, Pesticide Subdiv, Agric and Food Chem Div.

    Google Scholar 

  • Clarkson VA (1968) Toxicity of TEMIK®, TEMIK® sulfoxide, and TEMIK® sulfone to bluegill sunfish. Union Carbide Agricultural Products Co, Inc., Report, File No. 10493 (unpublished).

    Google Scholar 

  • Clarkson VA, Haines RG, Hensley WH, Rowe BK (1969) Report on additional field tests with TEMIK® 10G aldicarb pesticide on the potential hazard to bobwhite quail. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Clarkson VA, Hensley WH (1968) Field evaluation of the toxic hazard of misapplied TEMIK® formulations to bobwhite quail and chickens. Union Carbide Agricultural Products Co, Inc., Project 111B32 (unpublished).

    Google Scholar 

  • Clarkson VA, Rowe BK (1970) Field evaluations of the toxic hazard of TEMIK® formulations 10G, 10GC, and 10GVB4 to bobwhite quail. Union Carbide Agricultural Products Co, Inc., File No. 12676 (unpublished).

    Google Scholar 

  • Conroy WJ, Carpenter CP, Cox EJ (1977) UC 21865—technical and 75% WP. Sensitization potential in guinea pigs as determined by intradermal injection. Carnegie-Mellon Insititute Report No. 40-12 (unpublished).

    Google Scholar 

  • Cope OE (1974) Toxicity of UC 21149 to rainbow trout and bluegill sunfish. Letter of 13 October, Fish Pesticide Research Laboratory, U.S. Department of the Interior (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1970a) TEMIK® aldicarb pesticide exposure trial I. Union Carbide Agricultural Products Co, Inc., Project Nos. 111A13, 116A16 (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1970b) TEMIK® aldicarb pesticide exposure trial III. Union Carbide Agricultural Products Co, Inc., Project Nos. 111A13, 116A16 (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1970c) TEMIK® aldicarb pesticide exposure trial IV. Union Carbide Agricultural Products Co, Inc., Project Nos. 111A13, 116A16 (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1970d) TEMIK® aldicarb pesticide exposure trial V. Union Carbide Agricultural Products Co, Inc., Project Nos. 111A13, 116A16 (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1971) TEMIK® aldicarb pesticide exposure trial VI. Union Carbide Agricultural Products Co, Inc., Project Nos. 111A13, 116A16 (unpublished).

    Google Scholar 

  • Cope OE, Romine RR (1973) TEMIK® 10G aldicarb pesticide. Results of aldicarb ingestion and exposure studies with humans and results of monitoring human exposure in working environments. Union Carbide Agricultural Products Co, Inc., File No. 18269 (unpublished).

    Google Scholar 

  • Corbett JR, Wright K, Baillie AC (1984) The biochemical mode of action of pesticides, 2nd Ed. Academic Press, London, pp 99–140.

    Google Scholar 

  • Debuyst B, Van Larebeke N (1983) Induction of sister-chromatid exchanges in human lymphocytes by aldicarb, thiofanox and methomyl. Mutat Res 113:242–243.

    Google Scholar 

  • DePass LR, Weaver EV, Mirro EJ (1985) Aldicarb sulfoxide/aldicarb sulfone mixture in drinking water of rats. J Toxicol Environ Hlth 16:163–172.

    CAS  Google Scholar 

  • Dorough HW (1970) Effect of TEMIK on methyl parathion toxicity to mice. Progress Report 2771, Texas Agricultural Experiment Station.

    Google Scholar 

  • Dorough HW, Davis RB, Ivie GW (1970) Fate of TEMIK-carbon-14 in lactating cows during a 14-day feeding period. J Agric Food Chem 18:135–142.

    PubMed  CAS  Google Scholar 

  • Dorough HW, Ivie GW (1968) TEMIK-S35 metabolism in a lactating cow. J Agric Food Chem 16:460–464.

    CAS  Google Scholar 

  • Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF (1985) Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli. Environ Mutagen 7(suppl 5):1–248.

    PubMed  CAS  Google Scholar 

  • Edwards CA, Lofty JR (1971) Nematicides and the soil fauna. Proc 6th Brit Insect Fung Conf, pp 158–166.

    Google Scholar 

  • el-Elaimy I (1986) Comparative studies on the effect of carbamate and organophosphorus insecticides on acetylcholinesterase activity in maternal and fetal tissue of rat. Proc Zool Soc A R Egypt 10:41–49.

    CAS  Google Scholar 

  • Ellman GL, Courtney KD, Andres V Jr, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95.

    PubMed  CAS  Google Scholar 

  • FAO/WHO (1980) Pesticide residues in food. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues. FAO Plant Production and Pro tection Paper 20 and 20 Suppl, Food and Agriculture Organization of the United Nations, Rome.

    Google Scholar 

  • FAO/WHO (1983) Pesticide residues in food. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues. FAO Plant Production and Pro tection Paper 46, Food and Agriculture Organization of the United Nations, Rome.

    Google Scholar 

  • Farlow RA, Pitre HN (1983) Effects of selected pesticide application routines on pest and beneficial arthropods on soybean in Mississippi. Environ Entomol 12:552–557.

    Google Scholar 

  • Field WE (1979a) UC 21149. Acute dermal toxicity in rabbits. CDC Research, Inc., Report No. CDC-UC-008-79 (unpublished).

    Google Scholar 

  • Field WE (1979b) UC 21149. Acute dermal toxicity in rats. CDC Research, Inc., Report No. CDC-UC-009-79 (unpublished).

    Google Scholar 

  • Field WE (1979c) UC 21149. Oral LD50 in rats. CDC Research, Inc., Report No. CDC-UC-007-79 (unpublished).

    Google Scholar 

  • Fiore MC, Anderson HA, Hong R, Golubjatnikov R, Seiser JE Nordstrom D, Hanrahan L, Belluck D (1986) Chronic exposure to aldicarb-contaminated groundwater and human immune function. Environ Res 41:633–645.

    PubMed  CAS  Google Scholar 

  • Fletcher DW, Taliaferro LC Jr (1987) 1987 Wildlife mortality survey following application of TEMIK® brand aldicarb to three major crops (preliminary report), Bio-Life Associates, Ltd., Report No. 87FV3 (unpublished).

    Google Scholar 

  • FMC Corporation (undated a) Furadan® insecticide/nematocide product manual.

    Google Scholar 

  • FMC Corporation (undated b) Pounce® insecticide technical data brochure.

    Google Scholar 

  • Foran JA, Germuska PJ, Delfino JJ (1985) Acute toxicity of aldicarb, aldicarb sulfoxide, and aldicarb sulfone to Daphnia laevis. Bull Environ Contam Toxicol 35:546–550.

    PubMed  CAS  Google Scholar 

  • Gage JC (1967) The significance of blood cholinesterase activity measurements. Residue Reviews 18:159.

    PubMed  CAS  Google Scholar 

  • Gawaad AAA, El-Minshawy AM, Zeid M (1972) Soil insecticides, VIII. Effect of some soil insecticides on broad beans and Egyptian clover nodule-forming bacteria. Zetralbl Bakteriol Parasitenk Infekt 127:172–177.

    CAS  Google Scholar 

  • Godek EG, Dolak MC, Naismith RW, Matthews RJ (1980a) Ames Salmonella/microsome plate test. Aldicarb sulfone. Pharmakon Laboratories Report No. PH-301-UC-003-80 (unpublished).

    Google Scholar 

  • Godek EG, Dolak MC, Naismith RW, (1980b) Ames Salmonella/microsome plate test. Aldicard sulfoxide. Pharmakon Laboratories Report No. PH-301-UC-002-80 (unpublished).

    Google Scholar 

  • Godek EG, Dolak MC, Naismith RW, (1980c) Ames Salmonella/microsome plate test. TEMIK aldicarb pesticide. Pharmakon Laboratories Report No. PH-301-UC-004-80 (unpublished).

    Google Scholar 

  • Godek EG, Naismith RW, Matthews RJ (1984a) Rat hepatocyte primary culture/ DNA repair test. Aldicarb technical. Pharmakon Research International, Inc., Report No. PH-311-UC-005-83 (unpublished).

    Google Scholar 

  • Godek EG, Naismith RW, Matthews RJ (1984b) Rat hepatocyte primary culture/ DNA repair test. Aldoxycarb technical. Pharmakon Research International, Inc., Report No. PH-311-UC-006-83.

    Google Scholar 

  • Gonzáles Cid M, Matos E (1984) Induction of sister-chromatid exchanges in cultured human lymphocytes by aldicarb, a carbamate pesticide. Mutat Res 138:175–179.

    Google Scholar 

  • Green R (1980) Food selection by skylarks:the effect of a pesticide on grazing preferences. In:Wright EN, Inglis IR, Feare CJ (eds) Bird problems in agriculture. BCPC Monograph Series No. 23, Croydon.

    Google Scholar 

  • Grob D (1956) The manifestations and treatment of poisoning due to nerve gas and other organic phosphate anticholinesterase compounds. Arch Intern Med 98:221.

    CAS  Google Scholar 

  • Guerzoni ME, Del Cupolo L, Ponti I (1976) Attivitá mutagenica degli anti-parassitari. Riv Sci Tecn Alim Nutr Um 6:161–165.

    CAS  Google Scholar 

  • Habeck DH, Haag KH (1984) The effect of aldicarb on non-target organisms (in citrus). Department of Entomology and Nematology, University of Florida, Proj Report (unpublished).

    Google Scholar 

  • Haines RG (1970a) Field evaluation of potential hazard of TEMIK® 10G aldicarb pesticide to valley quail and ring-necked pheasants, trial I. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Haines RG (1970b) Field evaluations of potential hazard of TEMIK® 10G aldicarb pesticides to valley quail and ring-necked pheasants, trial II. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Haines RG (1970c) TEMIK® 10G granular pesticide. Field evaluations of potential hazard of TEMIK® 10G aldicarb pesticide to valley quail and ring-necked pheasants in sugar beet plantings, trial III. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Haines RG (1971a) Continued field evaluations on the potential hazards of TEMIK® 10G aldicarb pesticide to bob white quail in cotton plantings. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Haines RG (1971b) Continued field evaluations on the potential hazard of TEMIK® 10G aldicarb pesticide to valley quail and ring-necked pheasants in a cotton planting. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Haines RG (1971c) Ingestion of aldicarb by human volunteers:a controlled study of the effects of aldicarb on man. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Hamada NN (1987a) Aldicarb sulfone technical. One-year feeding study in dogs. Hazleton Laboratories America, Inc., Report No. 400-702 (unpublished).

    Google Scholar 

  • Hamada NN (1987b) Aldicarb technical. One-year feeding study in dogs. Hazleton Laboratories America, Inc., Report No. 400-706, (unpublished).

    Google Scholar 

  • Hamada NN, Hagen WH, Alsaker RD, Vargas KV, Marshall PM (1985a) Two-week oral toxicity study in beagle dogs. Aldicarb sulfone (aldoxycarb) technical. Hazleton Laboratories America, Inc., Report No. 400-701 (unpublished).

    Google Scholar 

  • Hamada NN, Hagen WH, Vargas FJ, Alsaker RD, Williams LD (1985b) Two-week dose range-finding study in beagle dogs. Aldicarb technical. Hazleton Laboratories America, Inc., Report No. 400-705 (unpublished).

    Google Scholar 

  • Hastings FL, Main AR, Iverson F (1970) Carbamylation and affinity constants of some carbamate inhibitors of acetylcholinesterase and the relation to analogous substrate constants. J Agric Food Chem 18:497–502.

    PubMed  CAS  Google Scholar 

  • Hicks BW, Dorough HW, Mehendale HM (1972) Metabolism of aldicarb pesticide in laying hens. J Agric Food Chem 20:151–156.

    PubMed  CAS  Google Scholar 

  • Hilbig V (1979) Report on palatability studies and trials regarding the acute toxicity of the plant protection products TEMIK 10G and TEMIK 1 OGGF (gypsum) with Japanese quails, chickens and sparrows. Federal Biological Agency, West Germany, Report (unpublished).

    Google Scholar 

  • Hill EF, Camardese MB (1982) Subacute toxicity testing with young birds:response in relation to age and interest variability of LC50 estimates. American Society for Testing and Materials Special Technical Publication No. 757.

    Google Scholar 

  • Hill EF, Camardese MB (1984) Toxicity of anticholinesterase insecticides to birds:technical grade versus granular formulations. Ecotoxicol Environ Saf 8:551–563.

    PubMed  CAS  Google Scholar 

  • Hill EF, Heath RG, Spann JW, Williams JD (1975) Lethal dietary toxicities of environmental pollutants to birds. Patuxent Wildlife Research Center, U.S. Fish and Wildlife Service, Special Scientific Report-Wildlife No. 191.

    Google Scholar 

  • Hollister TA, Shuba PJ (1981) Acute toxicity of TEMIK® to mysid shrimp (Mysidopsis bahia). EG&G Bionomics Project No. R18, Report No. BP-81-6-89 (unpublished).

    Google Scholar 

  • Hudson RH, Haegele MA, Tucker RK (1979) Acute oral and percutaneous toxicity of pesticides to mallards:correlations with mammalian toxicity data. Toxicol Appl Pharmacol 47:451–460.

    PubMed  CAS  Google Scholar 

  • Hudson RH, Tucker RK, Haegele MA (1972) Effect of age on sensitivity:acute oral toxicity of 14 pesticides to mallard ducks of several ages. Toxicol Appl Pharmacol 22:556–561.

    PubMed  CAS  Google Scholar 

  • Hudson RH, Tucker RK, Haegele MA (1984) Handbook of toxicity of pesticides to wildlife, 2nd Ed. U.S. Fish and Wildlife Service Research Publication 154.

    Google Scholar 

  • Ivett JL, Myhr BC, Lebowitz HD (1984) Mutagenicity evaluation of aldicarb technical 93.47% in the bone marrow cytogenetic assay. Litton Bionetics, Inc., Report No. 22202 (unpublished).

    Google Scholar 

  • Johansen C, Eves J (1967) Systemic insecticides as lygus bug controls compatible with bee pollination on alfalfa. J Econ Entomol 60:1690–1696.

    CAS  Google Scholar 

  • Johansen C, Rincker CM, George DA, Mayer DF, Kious CW (1984) Effects of aldicarb and its biologically active metabolites on bees. Environ Entomol 13:1386–1398.

    CAS  Google Scholar 

  • Johnson HE, Carpenter CP (1966a) TEMIK (technical grade compound 21149). Comparative behavioral effect in rats. Mellon Institute Report No. 29-89 (unpublished).

    Google Scholar 

  • Johnson HE, Carpenter CP (1966b) TEMIK (technical grade compound 21149). Demyelination potential in chickens. Mellon Institute Special Report No. 29-90 (unpublished).

    Google Scholar 

  • Johnson HE, Sullivan LJ, Carpenter CP (1968a) Studies on an effective therapy for overdoses of TEMIK, TEMIK sulfoxide, and TEMIK sulfone in the rat. Mellon Institute Report No. 31-139 (unpublished).

    Google Scholar 

  • Johnson HE, Sullivan LJ, Carpenter CP (1968b) TEMIK (UC 21149). Anidotal therapy in rats following administration of multiple lethal doses. Mellon Institute Report No. 31-146 (unpublished).

    Google Scholar 

  • Jones AS (1976) Metabolism of aldicarb by five soil fungi. J Agric Food Chem 24:115–117.

    PubMed  CAS  Google Scholar 

  • Kimura KK, McNamara BP, Sim VM (1960) Intravenous administration of VX in man. C.R.D.L.R. 3017.

    Google Scholar 

  • Knaak JB, Tallant MJ, Sullivan LJ (1966) The metabolism of 2-methy1-2(methylthio)-propionaldehyde O-(methylcarbamoyl)oxime in the rat. J Agric Food Chem 14:573–578.

    CAS  Google Scholar 

  • Knott W, Beliles RP (1966) UC 21149. Acute toxicity in sunfish. Woodard Research Corp Report (unpublished).

    Google Scholar 

  • Landau M, Tucker JW Jr (1984) Acute toxicity of EDB and aldicarb to young of two estuarine fish species. Bull Environ Contam Toxicol 33:127–132.

    PubMed  CAS  Google Scholar 

  • Lebrun A, Cerf C (1960) Note préliminaire sur la toxicité pour l’homme d’un insecticide organophosphore (Dipterex). Bull WHO 22:579 (French).

    PubMed  CAS  Google Scholar 

  • Lee MH, Ransdell JF (1984) A farmworker death due to pesticide toxicity:a case report. J Toxicol Environ Hlth 14:239–246.

    CAS  Google Scholar 

  • Leng JM, Schardein JL, Blair M (1983) Aldicarb. Teratology study in rabbits. International Research and Development Corp Report No. 369-107 (unpublished).

    Google Scholar 

  • Lightfoot EN, Thorne PS, Jones RL, Hansen JL, Romine RR (1987) Laboratory studies on mechanisms for the degradation of aldicarb, aldicarb sulfoxide and aldicarb sulfone. Environ Toxical Chem 6:377–394.

    CAS  Google Scholar 

  • Lijinsky W, Elespuru RK (1976) Mutagenicity and carcinogenicity of N-nitroso derivatives of carbamate insecticides. In: Walker EA, Bogovski P, Griciute L (eds) Environmental N-nitroso compounds: analysis and formation. IARC Scientific Publication No. 14, International Agency for Research on Cancer, Lyon, pp 425–428.

    Google Scholar 

  • Lijinsky W, Schmähl D (1978) Carcinogenicity of N-nitroso derivatives of N-methylcarbamate insecticides in rats. Ecotoxicol Environ Saf 2:413–419.

    PubMed  CAS  Google Scholar 

  • Lin S-C, Funke BR, Schulz JT (1972) Effects of some organophosphate and carbamate insecticides on nitrification and legume growth. Plant Soil 37:489–496.

    CAS  Google Scholar 

  • Lund RC (1970) Observations concerning the exposure of ring-necked pheasants to simulated spills of TEMIK 10G. Letter of 17 September, Division of Fish and Game, Department of Conservation and Economic Development, State of New Jersey.

    Google Scholar 

  • Lund RC, Haines RG (1969) Field evaluation of TEMIK® 10G aldicarb pesticide. Potential hazard to white-tail deer and cottontail rabbits from simulated spills. Union Carbide Agricultural Products Co, Inc., Report No. 49-29 (unpublished).

    Google Scholar 

  • Macek KJ, and McAllister WA (1970) Insecticide susceptibility of some common fish family representatives. Trans Am Fish Soc 99:20–27.

    CAS  Google Scholar 

  • Makawi AAM, Abdel-Nasser M, Abdel-Moneim AA (1979) Effect of some pesticides on certain micro-organisms, contributing to soil fertility. Zbl Bakt Abt II 134:5–12.

    CAS  Google Scholar 

  • Mann JB, Danauskas JX (1984) Human effects associated with the use of aldicarb on cotton in Sudan, Africa. In:Veziroğlu TN (ed) The Biosphere:Problems and Solutions, Elsevier, Amsterdam, pp 571–578.

    Google Scholar 

  • Maronpot RR, Weil CS, Geary PL, Frank FR (1980a) Effect of a single oral dose of aldicarb on cholinesterase inhibition and recovery in the dog. Carnegie-Mellon Institute Report No. 43-4 (unpublished).

    Google Scholar 

  • Maronpot RR, Weil CS, Geary PL, Frank FR (1980b) Effect of a single peroral dose of aldicarb on cholinesterase inhibition and recovery in the rabbit. Carnegie-Mellon Institute Report No. 43-3 (unpublished).

    Google Scholar 

  • Maronpot RR, Weil CS, Geary PL, Frank FR (1980c) Effect of a single peroral dose of aldicarb on cholinesterase inhibition and recovery in the rat. Carnegie-Mellon Institute Report No. 43-2 (unpublished).

    Google Scholar 

  • Marshall TC, Dorough HW (1977) Bioavailability in rats of bound and conjugated plant carbamate insecticide residues. J Agr Food Chem 25:1003–1009.

    CAS  Google Scholar 

  • Marshall TC, Dorough HW (1979) Biliary excretion of carbamate insecticides in the rat. Pestic Biochem Physiol 11:56–63.

    Google Scholar 

  • Medd RK, Roberts NL (1972) Palatability and acceptability of TEMIK (corn cob and coal formulations) to the pheasant and the pigeon. Huntingdon Research Centre Report No. 5419/72/815 (unpublished).

    Google Scholar 

  • Metcalf RL, Fukuto TR, Collins C, Borck K, Burk J, Reynolds HT, Osman MF (1966) Metabolism of 2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)oxime in plant and insect. J Agric Food Chem 14:579–584.

    CAS  Google Scholar 

  • Mizuta HM, Johansen CA (1972) The hazard of plant-systemic insecticides to nectar-collecting bees. Washington Agric Expt Sta Tech Bull No. 72.

    Google Scholar 

  • Moorefield HH, Hodges LR, Meeker RL (1973) Human monitoring study of field application of TEMIK® 15G. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Myers RC, DePass LR, Frank FR (1983a) TEMIK® 5G (corn cob grit). Acute peroral toxicity and eye irritancy study. Union Carbide Bushy Run Research Center Report No. 46-100 (unpublished).

    Google Scholar 

  • Myers RC, DePass LR, Frank FR (1983b) TEMIK® 5G, COUNTER® 5G and FURADAN® 5G. Acute percutaneous toxicity studies. Union Carbide Bushy Run Research Center Report No. 46-43 (unpublished).

    Google Scholar 

  • Myers RC, DePass LR, Frank FR (1984) TEMIK® 15GG; TEMIK® 15G GRIT. Acute percutaneous toxicity study using the Hill Top Chamber®. Union Carbide Bushy Run Research Center Report No. 47-61 (unpublished).

    Google Scholar 

  • Myers RC, Weil CS, Carpenter CP (1975a) TEMIK 10G; A,B,C,D, T73V023; 1975. Acute 4-hour skin penetration of rats. Carnegie-Mellon Institute Report No. 38-40 (unpublished).

    Google Scholar 

  • Myers RC, Weil CS, Cox EF (1975b) TEMIK 10G BC (coal); 10G and 15G (gypsum); 15G (corn cob). Comparative toxicity studies via peroral, dermal, and inhalation routes. Carnegie-Mellon Institute Report No. 38-141 (unpublished).

    Google Scholar 

  • Myers RC, Weil CS, Frank FR (1982) TEMIK® 5G (corn cob grits). Percutaneous toxicity and skin irritancy study. Union Carbide Bushy Run Research Center Report No. 45-88 (unpublished).

    Google Scholar 

  • Nachreiner DJ, Klonne DR, Frank FR (1985) Aldicarb solution (in DCM). LC50 aerosol acute inhalation toxicity test. Union Carbide Bushy Run Research Center Report No. 48-136 (unpublished).

    Google Scholar 

  • Namba T, Nolte CT, Jackerel J, Grob D (1971) Organophosphate insecticides. Am J Med 50:475.

    PubMed  CAS  Google Scholar 

  • Narayanan R, Balasubramanian A (1979) Effect of aldicarb on the growth, respiration and (14C)-glucose metabolism of Azotobacter chroococcum BEIJ. J Environ Sci Hlth B14:383–392.

    CAS  Google Scholar 

  • National Cancer Institute (1979) Bioassay of aldicarb for possible carcinogenicity. Carcinogenesis Technical Report Series No. 136, U.S. Department of Health, Education, and Welfare, NIH Publ. No. 79-1391.

    Google Scholar 

  • National Research Council (1977) Drinking water and health. National Academy of Sciences Press, Washington, DC, pp 635–643.

    Google Scholar 

  • National Research Council (1980) Drinking water and health, Vol 3. National Academy of Sciences Press, Washington, DC.

    Google Scholar 

  • National Research Council (1983) Drinking water and health, Vol. 5. National Academy of Sciences Press, Washington, DC, pp 10–12.

    Google Scholar 

  • National Research Council (1986) Drinking water and health, Vol 6. National Academy of Sciences Press, Washington, DC, pp 303–309.

    Google Scholar 

  • Natoff IL, Reiff B (1973) Effect of oximes on the acute toxicity of anticholinesterase carbamates. Toxicol Appl Pharmacol 25:569–573.

    PubMed  CAS  Google Scholar 

  • Nycum JS, Carpenter CP (1968a) Toxicity studies on TEMIK and related carbamates (7-Day feeding study). Mellon Institute Report No. 31-48 (unpublished).

    Google Scholar 

  • Nycum JS, Carpenter CP (1968b) Toxicity studies on the probable “non-carbamate” plant metabolites of TEMIK. Mellon Institute Report No. 31-30 (unpublished).

    Google Scholar 

  • Olson LJ, Erickson BJ, Hindsill RD, Wyman JA, Porter WP, Binning LK, Bidgood RC, Nordheim EV (1987) Aldicarb immunomodulation in mice:an inverse dose-response to parts per billion levels in drinking water. Arch Environ Contam Toxicol 16:433–439.

    PubMed  CAS  Google Scholar 

  • Oshima H, Bartsch H (1981) Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine. Cancer Res 41:3658–3662.

    Google Scholar 

  • Pandey SY (1977) Human exposure study on TEMIK® 10G. Union Carbide India Ltd. Report (unpublished).

    Google Scholar 

  • Payne LK Jr, Stansbury HA, Weiden MHJ (1966) The synthesis and insecticidal properties of some cholinergic trisubstituted acetaldehyde O-(methyl-carbamoyl)-oximes. J Agric Food Chem 14:356–365.

    CAS  Google Scholar 

  • Pendergrass JE (1979) The impact of systemic insecticides on insect pests and their natural enemies in cotton. Ph.D. Dissertation, Mississippi State University (unpublished).

    Google Scholar 

  • Pickering QH, Gilliam WT (1982) Toxicity of aldicarb and fonofos to the early-life-stage of the fathead minnow. Arch Environ Contam Toxicol 11:699–702.

    PubMed  CAS  Google Scholar 

  • Pozzani UC, Carpenter CP (1966) Response of rats living for 28 days on topsoil treated with UC 21149 10G-1. Mellon Institute Report No. 29-2 (unpublished).

    Google Scholar 

  • Pozzani UC, Carpenter CP (1968a) Sensitizing potential in guinea pigs as determined by a modified landsteiner test. Mellon Institute Report No. 31-143 (unpublished).

    Google Scholar 

  • Pozzani UC, Carpenter CP (1968b) TEMIK 10G and TEMIK 10G-V. Response of rats to saturated vapors generated under simulated greenhouse conditions. Mellon Institute Report No. 31-173 (unpublished).

    Google Scholar 

  • Quarles JM, Sega MW, Schenley CK, Linjinsky W (1979) Transformation of hamster fetal cells by nitrosated pesticides in a transplacental assay. Cancer Res 39:4525–4533.

    PubMed  CAS  Google Scholar 

  • Rashid KA, Mumma RO (1986) Screening pesticides for their ability to damage bacterial DNA. J Environ Sci Hlth B21:319–334.

    CAS  Google Scholar 

  • Relton J (1970) Wild life survey. TEMIK® 10G aldicarb pesticide on sugar beets; Suffolk, England, 1970. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Ridgeway RL, Lingren PD, Cowan CB, Davis JW (1967) Populations of arthropod predators and Heliothis spp. after applications of systemic insecticides to cotton. J Econ Entomol 60:1012–1016.

    Google Scholar 

  • Roberts BL, Dorough HW (1984) Relative toxicities of chemicals to the earthworm Eisenia foetida. Environ Toxicol Chem 3:67–78.

    CAS  Google Scholar 

  • Romine RR (1973a) Accumulation of aldicarb residues in fish tissue from chronic exposure to aldicarb, aldicarb sulfoxide and aldicarb sulfone in aquaria water. Union Carbide Agricultural Products Co, Inc., Report, File No. 19009 (unpublished).

    Google Scholar 

  • Romine RR (1973b) Aldicarb pesticide. Aldicarb residues in milk and meat of cows fed aldicarb sulfoxide and aldicarb sulfone in the daily diet. Union Carbide Agricultural Products Co, Inc., Report, File No. 18125 (unpublished).

    Google Scholar 

  • Romine RR, Chancey EL, Jones RL (1985) The sampling and extraction of TEMIK® treated soils for aldicarb residue determinations. Union Carbide Agricultural Products Co, Inc., manuscript (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Cameron DM (1977a) A comparison of the acute oral toxicity (LD50) of three formulations of TEMIK 10G to the japanese quail. Huntingdon Research Centre Report No. UNC 68 WL/771042 (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Cameron DM (1978a) A comparison of the palatability to the ring-necked pheasant of three formulations of TEMIK 10G with other granular pesticides. Huntingdon Research Centre Report No. UNC 69 C/78938 (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Cameron DM (1978b) A comparison of the palatability to the ring-necked pheasant of two formulations of TEMIK. Huntingdon Research Centre Report No. UNC 69 G/78399 (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Cameron DM (1978c) A comparison of the palatability to the zebra finch of two formulations of TEMIK. Huntingdon Research Centre Report No. UNC 69 G/78398 (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Cameron DM (1979) The effect of granule size on the toxic hazard to passeriformes of TEMIK 10G. Huntingdon Research Centre Report No. UNC 69 B/78721 (unpublished).

    Google Scholar 

  • Ross DB, Roberts NL, Eichler AJ (1977b) TEMIK 10G gypsum formulation (blue) wildlife surveys following application to four sugar beet and four potato fields. Huntingdon Research Centre Report No. UNC 57/77/4581 (unpublished).

    Google Scholar 

  • SanSebastian JR, Naismith RW, Matthews RJ (1984) In vitro chromosome aberration analysis in chinese hamster ovary cells (CHO). Aldoxycarb technical. Pharmakon Research International, Inc., Report No. PH 320-UC-005-83 (unpublished).

    Google Scholar 

  • Schafer EW Jr (1975) Summary of three data sheets on avian toxicity. Letter of 28 April, Union Carbide Agricultural Products Co, Inc. (unpublished).

    Google Scholar 

  • Schlinke JC (1970) Toxicologic effects of five nematocides in chickens. Am J Vet Res 31:1119–1121.

    PubMed  CAS  Google Scholar 

  • Schneider C, Vilkas AG, Hutchinson C (1979a) The acute toxicity of aldicarb technical to the bluegill sunfish, Lepomis macrochirus Refinesque. Union Carbide Environmental Services Report No. 11504-14-04 (unpublished).

    Google Scholar 

  • Schneider C, Vilkas AG, Hutchinson C (1979b) The acute toxicity of aldicarb technical to the rainbow trout, Salmo gairdneri Richardson. Union Carbide Environmental Services Report No. 11504-14-03 (unpublished).

    Google Scholar 

  • Schupner JK, Vilkas AG, Hutchinson C (1980) The acute toxicity of technical grade TEMIK (95.6%) to the mysid shrimp, Mysidopsis bahia. Union Carbide Environmental Services Report No. 11504-14-01 (unpublished).

    Google Scholar 

  • Seiler JP (1977) Nitrosation in vitro and in vivo by sodium nitrite, and mutagenicity of nitrogenous pesticides. Mutat Res 48:225–236.

    PubMed  CAS  Google Scholar 

  • Sharaf, AA, Temtamy SA, de Hondt HA, Belal MH, Kassam EA (1982) Effect of aldicarb (TEMIK) a carbamate insecticide, on chromosomes of the laboratory rat. Egypt J Genet Cytol 11:135–144.

    Google Scholar 

  • Shell Chemical Company (undated) Pydrin® insecticide. Technical manual.

    Google Scholar 

  • Shrivastava KN (1975) Determination of human exposure levels in commercial application of TEMIK® 10G on potatoes by gloved hand and hand operated applicators. Union Carbide India Ltd. Report (unpublished).

    Google Scholar 

  • Sim VM, Stubbs JL (1960) VX, percutaneous studies in man. C.R.D.L.R. 3015.

    Google Scholar 

  • Spurr HW, Chancey EL (1968) TEMIK® insecticide. Interactions between TEMIK® and microorganisms and their importance to ecological relationships in soil. Union Carbide Agricultural Products Company, Inc., Report No. 9208 (unpublished).

    Google Scholar 

  • Spurr HW, Sousa AA (1974) Potential interactions of aldicarb and its metabolites on non-target organisms in the environment. J Environ Qual 3:130–133.

    CAS  Google Scholar 

  • Stankowski LF, Naismith RW, Matthews RJ (1985a) CHO/HGPRT mammalian cell forward gene mutation assay. Aldicarb. Pharmakon Research International, Inc., Report No. PH 314-UC-003-84 (unpublished).

    Google Scholar 

  • Stankowski LF, Naismith RW, Matthews RJ (1985b) CHO/HGPR mammalian cell forward gene mutation assay. Aldoxycarb. Pharmakon Research International, Inc., Report No. PH 314-UC-002-84 (unpublished).

    Google Scholar 

  • Stenersen J (1979a) Action of pesticides on earthworms. Part I:the toxicity of cholinesterase-inhibiting insecticides to earthworms as evaluated by laboratory tests. Pestic Sci 10:66–74.

    CAS  Google Scholar 

  • Stenersen J (1979b) Action of pesticides on earthworms. Part III:inhibition and reactivation of cholinesterases in Eisenia foetida (Savigny) after treatment with cholinesterase-inhibiting insecticides. Pestic Sci 10:113–122.

    CAS  Google Scholar 

  • Sterman AB, Varma A (1983) Evaluating human neurotoxicity of the pesticide aldicarb:when man becomes the experimental animal. Neurobehav Toxicol Teratol 5:493–495.

    PubMed  CAS  Google Scholar 

  • Sterri SH, Rognerud B, Fiskum SE, Lyngaas S (1979) Effect of toxogonin and P2S on the toxicity of carbamates and organophosphorus compounds. Acta Pharamacol Toxicol 45:9–15.

    CAS  Google Scholar 

  • Striegel JA, Carpenter CP (1962) Range finding tests on compound 21149. Mellon Institute Report No. 25-53 (unpublished).

    Google Scholar 

  • Striegel JA, Carpenter CP (1963) Comparison of the acute toxicity of compound 21149 with several of its analogues. Mellon Institute Report No. 26-29 (unpublished).

    Google Scholar 

  • Sullivan LJ, Carpenter CP (1968a) The excretion of C14 equivalents of 2-Methy1-2-(methylthio-C14)propionaldehyde O-(methylcarbamoyl)oxime sulfone by the rat after a single peroral dose. Mellon Institute Report No. 31-130 (unpublished).

    Google Scholar 

  • Sullivan LJ, Carpenter CP (1968b) The urinary excretion of C14 equivalents of 2-methyl-2(methylthio-C14)propionaldehyde O-(methylcarbamoyl)oxime in the dog and their metabolic profile as revealed by silica gel chromatography. Mellon Institute Report No. 31-135 (unpublished).

    Google Scholar 

  • Sullivan LJ, Carpenter CP (1968c) Urinary metabolic profiles as determined by silica gel chromatography of urines from rats and dogs dosed with TEMIK sulfone. Mellon Institute Report No. 31-138a (unpublished).

    Google Scholar 

  • Sullivan LJ, Carpenter CP (1974) Preliminary metabolism of 14C-S-methyl aldicarb nitrile in the rat. Carnegie-Mellon Institute Report No. 37-38 (unpublished).

    Google Scholar 

  • Tait R (1972) Aldicarb wildlife survey 1972. Duphar-Midox Ltd. Report (unpublished).

    Google Scholar 

  • Tewfik MS, Embabi MS, Hamadi YA (1975) Efficiency of Rhizobium leguminosarum as affected by certain herbicides and nematocides. Zbl Bakt Abt II 130:725–731.

    CAS  Google Scholar 

  • Thomas PT, Ratajczak HV, Eisenberg WC, Furedi-Machacek M, Ketels KV, Barbera PW (1987) Evaluation of host resistance and immunity in mice exposed to the carbamate pesticide aldicarb. Fund Appl Toxicol 9:82–89.

    CAS  Google Scholar 

  • Tingey WM (1986) New York State potato production and TEMIK® aldicarb pesticide. Letter of 8 January, Department of Entomology, Cornell University (unpublished).

    Google Scholar 

  • Trutter JA (1987) Acute oral toxicity in cynomolgus monkeys:aldicarb sulfoxide/sulfone residue in bananas. Aldicarb sulfoxide/sulfone residue in watermelon. Hazleton Laboratories America, Inc., Report No. 400-720 (unpublished).

    Google Scholar 

  • Tyl RW (1988) Developmental Toxicity evaluation of aldicarb technical administered by gavage to CD® (Sprague Dawley) Rats. Bushy Run Research Center. Report No. 51-551 (unpublished).

    Google Scholar 

  • Union Carbide Agricultural Products Company, Inc. (1986) USA Summary of alleged overexposure to TEMIK® aldicarb pesticide from 1966 to 1986. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Union Carbide India Ltd. (1979) Human exposure study and clinical toxicology of TEMIK® 10G. Union Carbide India Ltd. Report (unpublished).

    Google Scholar 

  • U.S. Environmental Protection Agency (1979) Toxicology handbook, mammalian and aquatic data. Report No. EPA-540/9-79-003. NTIS/PB80-196876, National Technical Information Service, Springfield, VA.

    Google Scholar 

  • U.S. Environmental Protection Agency (1981a) Acephate, aldicarb, carbophenothion, DEF, EPN, ethoprop, methyl parathion, and phorate:their acute and chronic toxicity, bioconcentration potential, and persistence as related to marine environments. EPA Report No. EPA-600/4-81-041. NTIS/PB81-244477, National Technical Information Service, Springfield, VA.

    Google Scholar 

  • U.S. Environmental Protection Agency (1981b) Tolerances and exemptions from tolerances for pesticide chemicals in or on raw agricultural commodities; aldicarb. Fed Regis 46:57047–57048.

    Google Scholar 

  • U.S. Environmental Protection Agency (1984) Final agenda, Scientific Advisory Panel, public meeting, Vol III. Executive Court Reporters, Washington, DC (unpublished).

    Google Scholar 

  • Verstraeta W, Voets JP (1974) Impact in sugar beet crops of some important pesticide treatment systems on the microbial and enzymatic constitution of the soil. Soil Biol Biochem 6:1263–1277.

    Google Scholar 

  • Vettorazzi G (1975) Toxicological decisions and recommendations resulting from the safety assessment of pesticide residues in food. CRC Crit Rev Toxicol 4:125–183.

    PubMed  CAS  Google Scholar 

  • Vilkas AG, Hutchinson C (1977) The acute toxicity of aldicarb technical to the water flea, Daphnia magna Straus. Union Carbide Environmental Services Report No. 11504-14-01 (unpublished).

    Google Scholar 

  • Wakefield M, Orme JPR, Ruston EA, Andrews L (1973) The determination of levels of aldicarb in urine and face masks. Huntingdon Research Centre Report No. UNC18/73491 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1963) Results of three months of inclusion of compound 21149 in the diet of rats. Mellon Institute Report No. 26-47 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1964) Results of a three generation reproduction study on rats fed compound UC 21149 in their diet. Mellon Institute Report No. 27-158 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1965) Two-year feeding of compound 21149 in the diet of rats. Mellon Institute Report No. 28-123 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1966a) Insecticide TEMIK. Teratogenic potential in rats. Mellon Institute Report No. 29-81 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1966b) Results of long-term tests for mouse skin carcinogenicity of three process residues, one epoxide and three compounds. Mellon Institute Report No. 29-34 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1966c) Two-year feeding of compound 21149 in the diet of dogs. Mellon Institute Report No. 29-5 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1968a) TEMIK 10G-V (10.3% granular formulation of compound 21149). Acute and 14-day dermal applications to rabbits. Mellon Institute Report No. 31-137 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1968b) TEMIK sulfoxide. Results of feeding in the diet of rats for six months and dogs for three months. Mellon Institute Report No. 31-141 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1968c) TEMIK sulfone. Results of feeding in the diet of rats for six months and dogs for three months. Mellon Institute Report No. 31-142 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1969a) 2-Methyl-2-(methylsulfinyl)propanol-1. Results of feeding in the diets of rats for one week. Mellon Institute Report No. 32-73 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1969b) Purified and technical TEMIK. Results of feeding in the diets of rats for one week. Mellon Institute Report No. 32-11 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1969c) TEMIK sulfoxide and TEMIK sulfone. Single rabbit skin penetration studies. Mellon Institute Report No. 32-78 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970a) Miscellaneous toxicity studies. Mellon Institute Report No. 33-18 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970b) Miscellaneous toxicity studies. Mellon Institute Report No. 33-92 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970c) TEMIK and other materials. Miscellaneous single dose peroral and parenteral LD50 assays and some joint action studies. Mellon Institute Report No. 33-7 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970d) TEMIK. Results of feeding in the diet of mice for 7 days. Mellon Institute Report No. 33-59 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970e) TEMIK. Results of feeding in the diets of rats for 7 days. Mellon Institute Report No. 33-5 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970f) TEMIK (T), TEMIK sulfoxide (TSO), TEMIK sulfone (TSO2), 1 : 1 TSO-TSO2. Results of feeding in the diet of rats for 7 days. Mellon Institute Report No. 33-81 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1970g) 1:1 TEMIK:TEMIK sulfone. Results of feeding in the diets of mice for 7 days. Mellon Institute Report No. 33-6 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1971) Miscellaneous toxicity studies. Mellon Institute Report No. 34-71 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1972a) Aldicarb (A), aldicarb sulfoxide (ASO), aldicarb sulfone (ASO2) and a 1 : 1 mixture of ASO:ASO2. Two-year feeding in the diet of rats. Mellon Institute Report No. 35-82 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1972b) Aldicarb. 18-Month feeding in diet of mice. Mellon Institue Report No. 35-70 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1972c) Miscellaneous toxicity studies. Mellon Institute Report No. 35-41 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1973) Aldicarb. Seven-day inclusion in diet of dogs. Carnegie-Mellon Institute Report No. 36-33 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974a) Aldicarb. Inclusion in the diet of rats for three generations and a dominant lethal mutagenesis test. Carnegie-Mellon Institute Report No. 37-90 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974b) Aldicarb. Inclusion in the diets of dogs for three months. Carnegie-Mellon Institute Report No. 37-12 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974c) Aldicarb. 18-Month feeding in the diet of mice, study II. Carnegie-Mellon Institute Report No. 37-98 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974d) Aldicarb oxime (ALL). Results of feeding in the diet of rats for 7 days. Carnegie-Mellon Institute Report No. 37-94 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974e) Peroral single dose to rats. Mellon Institute Report No. 37-10 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974f) TEMIK aldicarb pesticide 10G and 15G. Range finding toxicity studies. Carnegie-Mellon Institute Report No. 37-39 (unpublished).

    Google Scholar 

  • Weil CS, Carpenter CP (1974g) UC 21865. Results of feeding in the diet of mice for 7 days. Carnegie-Mellon Institute Report No. 37-89 (unpublished).

    Google Scholar 

  • Weil CS, Conroy WJ, Condra NI, Cox EF (1977) Aldicarb sulfone. UC 21865. 19-Day rabbit skin inunction during 26 calendar days. Mellon Institute Report 40-13 (unpublished).

    Google Scholar 

  • Weil CS, Cox EF (1975) Aldicarb sulfoxide and aldicarb sulfone. Cholinesterase inhibition results after periods of one to fifty-six days of inclusion in the diets of rats. Carnegie-Mellon Institute Report No. 38-115 (unpublished).

    Google Scholar 

  • Weil CS, Cox EF (1976) Reanalysis of tumor incidence Data of aldicarb. 18-month mouse feeding studies. Carnegie-Mellon Institute Report No. 39-55 (unpublished).

    Google Scholar 

  • West JS, Carpenter CP (1965a) Range finding tests on compound 21786, 2-methyl-2-methylthiopropionaldehyde oxime. Mellon Institute Report No. 28-70 (unpublished).

    Google Scholar 

  • West JS, Carpenter CP (1965b) The single dose peroral toxicity of compounds 20299, 21149, 19786 and 20047A for white leghorn cockerels. Mellon Institute Report No. 28-30 (unpublished).

    Google Scholar 

  • West JS, Carpenter CP (1966a) Miscellaneous acute toxicity data. Mellon Institute Report No. 28-140 (unpublished).

    Google Scholar 

  • West JS, Carpenter CP (1966b) TEMIK (compound 21149, technical). Joint action with selected organic phosphate and carbamate pesticides. Mellon Institute Report No. 29-98 (unpublished).

    Google Scholar 

  • Whitlock NH, Schuman SH, Loadholt CB (1982) Executive summary and epidemiologic survey of potential acute health effects of aldicarb in drinking water—Suffolk County, N.Y. South Carolina Pesticide Hazard Assessment Program Center, Medical University of South Carolina, Charleston. Prepared for the Health Effects Branch, Hazard Evaluation Division, Office of Pesticide Programs, U.S. Environmental Protection Agency.

    Google Scholar 

  • Wilkinson CF, Babish JF, Lemley AJ, Soderlund DM (1983) A toxicological evaluation of aldicarb and its metabolites in relation to the potential human health impact of aldicarb residues in Long Island ground water. Institute for Comparative and Environmental Toxicology, Cornell University, Report (unpublished).

    Google Scholar 

  • Williams F (1966) Human exposure study in the field application of TEMIK 10G on cotton. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

  • Wills JH (1972) The measurement and significance of changes in the cholinesterase activities of erythrocytes and plasma in man and animals. CRC Crit Rev Toxicol 1:153–202.

    Google Scholar 

  • Wolfe, GW, Bristol KL (1980a) Acute oral toxicity study in rats. TEMIK TSX. Hazleton Laboratories America, Inc., Report No. 400-631 (unpublished).

    Google Scholar 

  • Wolfe GW, Bristol KL (1980b) Primary eye irritation study in rabbits. TEMIK TSX. Hazleton Laboratories America, Inc., Report No. 400-634 (unpublished).

    Google Scholar 

  • Wolfe GW, Voelker RW, Dauvin EM (1980) Acute dermal toxicity study in rabbits. TEMIK TSX. Hazleton Laboratories America, Inc., Report No. 400-632 (unpublished).

    Google Scholar 

  • Wolfe GW, Wentz KL (1980) Primary dermal irritation study in rabbits. TEMIK TSX. Hazleton Laboratories America, Inc., Report No. 400-633 (unpublished).

    Google Scholar 

  • Woodside MD, Weil CS, Cox EF (1977a) Aldicarb sulfone. Inclusion in the diet of rats for three generations, dominant lethal mutagenesis and teratology studies. Carnegie-Mellon Institute Report No. 40-1 (unpublished).

    Google Scholar 

  • Woodside MD, Weil CS, Cox EF (1977b) Aldicarb sulfone. 18-Month feeding in the diet of mice. Carnegie-Mellon Institute Report No. 40-38 (unpublished).

    Google Scholar 

  • WHO (1966) WHO insecticide evaluation and testing programme, stage I, mammalian toxicity report. Toxicology Research Univ., Carshalton, U.K., Report (unpublished).

    Google Scholar 

  • Zigas RP (1973) Effect of TEMIK® 10G on beneficial organisms associated with cotton grown in the USA. Union Carbide Agricultural Products Co, Inc., Report (unpublished).

    Google Scholar 

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Baron, R.L., Merriam, T.L. (1988). Toxicology of Aldicarb. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 105. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3876-8_1

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