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Experimental Osteomyelitis

  • Chapter
Orthopedic Infection

Part of the book series: Clinical Topics in Infectious Disease ((CLIN.TOP.INFECT))

Abstract

Clinical research into osteomyelitis is difficult because of the multiple variables involved in the disease process and the variability in the treatment protocols. There are four major factors influencing the treatment and prognosis of chronic osteomyelitis: (a) degree of necrosis, (b) condition of the host, (c) site and extent of involvement, and (d) the disabling effects of the disease itself. The classification of osteomyelitis offered by Waldvogel et al. (Table 4.1) was the first system to identify the host as a separate problem (37). In this classification the clinical types of osteomyelitis are: hematogenous osteomyelitis (long bone and vertebral), contiguous focus osteomyelitis without generalized vascular disease, and contiguous focus osteomyelitis with generalized vascular disease. Contiguous focus osteomyelitis develops secondary to an area of open trauma, prior surgery, or soft tissue infection and is usually polymicrobic in nature.

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References

  1. Andriole VT, Nagel DA, Southwick WO: Chronic staphylococcal osteomyelitis: An experimental model. Yale J Biol Med 1:33–39, 1974.

    Google Scholar 

  2. Andriole VT, Nagel DA, Southwick WO: A paradigm for human chronic osteomyelitis. J Bone Joint Surg 55A:1511–1515, 1973.

    Google Scholar 

  3. Cierny G, Mader JT: Adult chronic osteomyelitis. Orthopedics 7:1557–1564, 1984.

    Google Scholar 

  4. Crane LR, Kapdi CC, Wolfe JN, Silberberg BK, Lerner AM: Xeroradiographic, bacteriologie, and pathologic studies in experimental staphylococcal osteomyelitis. Proc Soc Exp Biol Med 156:303–314, 1977.

    PubMed  CAS  Google Scholar 

  5. Desyine M, Rosario E, Isenberg HD: Acute hematogenous osteomeylitis: An experimental model. Surgery 79:97–99, 1976.

    Google Scholar 

  6. Fitzgerald RH: Experimental osteomyelitis: Description of a canine model and the role of depot administration of antibiotics in the prevention and treatment of sepsis. J Bone Joint Surg 65A:371–380, 1983.

    Google Scholar 

  7. Haldeman KO: Acute osteomyelitis. A clinical and experimental study. Surg Gynecol Obstet 59:25–31, 1934.

    Google Scholar 

  8. Holzman RS, Bishko F: Osteomyelitis in heroin addicts. Ann Intern Med 75:693–696, 1971.

    PubMed  CAS  Google Scholar 

  9. LaMont JT, Sonnenblick EB, Rothman S: Role of clostridial toxin in the pathogenesis of clindamycin colitis in rabbits. Gastroenterology 70:356–361, 1979.

    Google Scholar 

  10. Lee Y-H, Kerstein MD: Osteomyelitis and septic arthritis. A complication of subclavian venous catheterization. N Engl J Med 285:1179–1180, 1971.

    Article  PubMed  CAS  Google Scholar 

  11. Leonard A, Comty CM, Shapiro FL, Raij L: Osteomyelitis in hemodialysis patients. Ann Intern Med 78:651–658, 1973.

    PubMed  CAS  Google Scholar 

  12. Lexer E.: Experimente über osteomyelitis. Arch Klin Chir 53:266–277, 1896.

    Google Scholar 

  13. Lexer E: Zur experimentellen erzeugung osteomyelitischer herde. Arch Klin Chir 48:181–200, 1894.

    Google Scholar 

  14. Mader JT, Guckian JC, Glass DL, Reinarz JA: Therapy with hyperbaric oxygen for experimental osteomyelitis due to Staphylococcus aureus in rabbits. J Infect Dis 138:312–318, 1978.

    Article  PubMed  CAS  Google Scholar 

  15. Mader JT, Morrison LT, Adams KR: Comparative evaluation of A-56619, A-56620, and Nafcillin in the treatment of experimental Staphylococcus aureus osteomyelitis. Antimicrob Agents Chemother 31:259–263, 1987.

    PubMed  CAS  Google Scholar 

  16. Mader JT, Wilson KJ: Comparative evaluation of cefamandole and cephalothin in the treatment of experimental Staphylococcus aureus osteomyelitis in rabbits. J Bone Joint Surg 65A:507–513, 1983.

    Google Scholar 

  17. Mader JT, Wilson KJ: Comparative evaluation of moxalactam and clindamycin in the treatment of experimental Staphylococcus aureus osteomyelitis, in 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract 105. Washington, DC: American Society of Microbiology, 1982.

    Google Scholar 

  18. Norden CW: Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and ce-phalothin. J Infect Dis 132:493–499, 1975.

    Article  PubMed  CAS  Google Scholar 

  19. Norden CW: Experimental osteomyelitis. V. Therapeutic trials with oxacillin and sisomicin alone and in combination. J Infect Dis 137:155–160, 1978.

    Article  PubMed  CAS  Google Scholar 

  20. Norden CW, Bryant R, Palmer D, Montgomerie JZ, Wheat J: Chronic osteomyelitis caused by Staphylococcus aureus: Controlled clinical trial of nafcillin therapy and nafcillin-rifampin therapy. South Med J 79:947–951, 1986.

    Article  PubMed  CAS  Google Scholar 

  21. Norden CW, Dickens DR: Experimental osteomyelitis. III. Treatment with cephaloridine. J Infect Dis 127:525–528, 1973.

    Article  PubMed  CAS  Google Scholar 

  22. Norden CW, Keleti E: Experimental osteomyelitis caused by Pseudomonas aeruginosa. J Infect Dis 141:71–75, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. Norden CW, Keleti E: Treatment of experimental staphylococcal osteomyelitis with rifampin and trimethoprim, alone and in combination. Antimicrob Agents Chemother 17:591–594, 1980.

    PubMed  CAS  Google Scholar 

  24. Norden CW, Kennedy E: Experimental osteomyelitis. I. A description of the model. J Infect Dis 122:410–418, 1970.

    Article  PubMed  CAS  Google Scholar 

  25. Norden CW, Kennedy E: Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone. J Infect Dis 124:565–571, 1971.

    Article  PubMed  CAS  Google Scholar 

  26. Norden CW, Myerowitz RL, Keleti E: Experimental osteomyelitis due to Staphylococcus aureus or Pseudomonas aeruginosa: A radiographic-pathological correlative analysis. Br J Exp Pathol 61:451–460, 1980.

    PubMed  CAS  Google Scholar 

  27. Norden CW, Shaffer M: Treatment of experimental chronic osteomyelitis due to Staphylococcus aureus with vancomycin and rifampin. J Infect Dis 147:352–357, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Norden CW, Shinner E: Ciprofloxacin as therapy for experimental osteomyelitis caused by Pseudomonas aeruginosa. J Infect Dis 151:291–294, 1985.

    Article  PubMed  CAS  Google Scholar 

  29. Norden CW, Shinners E, Niederriter K: Clindamycin treatment of experimental chronic osteomyelitis due to Staphylococcus aureus. J Infect Dis 153:956–959, 1986.

    Article  PubMed  CAS  Google Scholar 

  30. Rissing JP, Buxton TB, Fisher J, Harris R, Shockley RK: Arachidonic acid facilitates experimental chronic osteomyelitis in rats. Infect Immun 49:141–144, 1985.

    PubMed  CAS  Google Scholar 

  31. Rissing JP, Buxton TB, Weinstein RS, Shockley RK: Model of experimental chronic osteomyelitis in rats. Infect Immun 47:581–586, 1985.

    PubMed  CAS  Google Scholar 

  32. Rodet A: Physiologie pathologique—etude expérimentale sur l’osteomyelite infectieuse. C R Acad Sci 9:569–571, 1885.

    Google Scholar 

  33. Scheman L, Janota M, Lewin P: The production of experimental osteomyelitis. JAMA 117:1525–1529, 1941.

    Google Scholar 

  34. Starr CL: Acute hematogenous osteomyelitis. Arch Surg 4:567–587, 1922.

    Google Scholar 

  35. Thompson RHS, Dubos RJ: Production of experimental osteomyelitis in rabbits by intravenous injection of Staphylococcus aureus. J Exp Med 68:191–206, 1938.

    Article  PubMed  CAS  Google Scholar 

  36. Van Wingerden GI, Lolans V, Jackson GG: Experimental Pseudomonas osteomyelitis. Treatment with sisomicin and carbenicillin. J Bone Joint Surg 56A: 1452–1458, 1974.

    Google Scholar 

  37. Waldvogel FA, Medoff G, Swartz MN: Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med 282:198–206, 260–266, 316–322, 1970.

    Article  PubMed  CAS  Google Scholar 

  38. Waldvogel FA, Vasey, H: Osteomyelitis: The past decade. N Engl J Med 303:360–370, 1980.

    Article  PubMed  CAS  Google Scholar 

  39. Zak O, Zak F, Rich R, Tosch W, Kradolfer F, Scheid WM: Experimental staphylococcal osteomyelitis in rats: Therapy with rifampin and cloxacillin alone or in combination, in Current Chemotherapy and Immunotherapy, P Periti, GG Grassi (eds). Washington, DC: American Society of Microbiology, pp 973–974, 1982.

    Google Scholar 

  40. Zimelis VW, Jackson GG: Activity of aminoglycoside antibiotics against Pseudomonas aeruginosa: Specificity and site of calcium and magnesium antagonism. J Infect Dis 127:663–669, 1973.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Jon T. Mader
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  2. Kenneth R. Adams
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Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Medicine, Episcopal Hospital, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1988 Springer-Verlag New York Inc.

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Mader, J.T., Adams, K.R. (1988). Experimental Osteomyelitis. In: Schlossberg, D. (eds) Orthopedic Infection. Clinical Topics in Infectious Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3870-6_4

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  • DOI: https://doi.org/10.1007/978-1-4612-3870-6_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8383-6

  • Online ISBN: 978-1-4612-3870-6

  • eBook Packages: Springer Book Archive

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