Abstract
In adults vertebral osteomyelitis differs from osteomyelitis at other sites in that, aside from postoperative infections, the infection almost always occurs by a hematogenous route. The tendency of osseous infections to localize in the vertebral body may be related to the nature of the vascular supply and the fact that the vertebral body is composed almost entirely of cancellous or spongy bone, which might provide a more suitable environment for infection to take place. Although it is difficult to estimate the relative proportion of vertebral to nonvertebral hematogenous osteomyelitis in adults, it appears that vertebral osteomyelitis is the more common disease (106). The typical patient is a middle-aged or elderly male without a history of underlying back disease and, in a significant number of patients, no history to account for a bacteremic episode.
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References
Abramovitz JN, Batson R, Yablon JS: Vertebral osteomyelitis: The surgical management of neurologic complications. Spine 11:418–420, 1986.
Acton RK: Anatomy of the spine, in Spinal Disorders: Diagnosis and Treatment, Ruge D, Wiltse LL (eds). Philadelphia, Lea & Febiger, 1977.
Allen EH, Cosgrove D, Millard FJC: The radiological changes in infections in the spine and their diagnostic value. Clin Radiol 29:31–40, 1978.
Al-Sheikh W, Sfakianakis GN, Mnaymneh W, Hourani M, Heal A, Duncan RC, Burnett A, Ashkar FS, Serafini AN: Subacute and chronic bone infections: Diagnosis using In-II, Ga-67, Tc-99 MDP bone scintigraphy and radiography. Radiology 155:501–506, 1985.
Ambrose BG, Alpert M, Neer CS: Vertebral osteomyelitis. A diagnostic problem. JAMA 197: 101–104, 1966.
American Thoracic Society: Treatment of tuberculosis and other mycobacterial disease. Am Rev Respir Dis 127:790–796, 1983.
Ariza J, Gudiol F, Valverde J, Pallares R, Fernandez-Viladrich P, Rufi G, Espadaler L, Fernandez-Nogues F: Brucellar spondylitis: A detailed analysis based on current findings. Rev Infect Dis 7:656–664, 1985.
Armstrong P, Chalmers AH, Green G, Irving JD: Needle aspiration/biopsy of the spine in suspected disc space infection. Br J Radiol 51:333–337, 1978.
Awad I, Bay JW, Peterson JM: Nocardial osteomyelitis of the spine with epidural spinal cord compression—A case report. Neurosurgery 15:254–256, 1984.
Baker AS, Ojemann RJ, Swartz MW, Richardson EP Jr: Spinal epidural abscess. N Engl J Med 293:463–468, 1975.
Bergman I, Wald ER, Meyer JD, Painter MJ: Epidural abscess and vertebral osteomyelitis following serial lumbar punctures. Pediatrics 72:476–480, 1983.
Bonakdarpour A, Gaines VD: The radiology of osteomyelitis. Orthop Clin North Am 14:21–36, 1983.
BonFiglio M, Lange TA, Kim YM: Pyogenic vertebral osteomyelitis: Disk space infections. Clin Orthop 96:234–247, 1973.
Brandt SJ, Thompson RL, Wenzel RP: Mycotic pseudoaneurysm of an aortic bypass graft and contiguous vertebral osteomyelitis due to Aspergillus fumigatus. Am J Med 79:259–261, 1985.
Bried JM, Galgiani JN: Coccidioides immitis infections in bones and joints. Clin Orthop 211:235–243, 1986.
Bundens DA, Rechtine GR: Sarcoidosis of the spine. Spine 11:209–212, 1986.
Byrne FO, Thrall TM, Wheat LJ: Hematogenous vertebral osteomyelitis: Pasturella multocida as the causative agent. Arch Intern Med 139:1182–1183, 1979.
Chari PR: Haematogenous pyogenic osteomyelitis of the spine: A study of 17 cases. Aust NZ J Surg 42:381–389, 1973.
Clinicopathologic Conference: Case 12. N Engl J Med 307:729–737, 1982.
Clinicopathologic Conference: Case 33. N Engl J Med 311:455–462, 1984.
Clinicopatholigic Conference: Case 37. N Engl J Med 315:748–754, 1986.
Cloward RB: Metastatic disc infection and osteomyelitis of the cervical spine. Spine 3:194–201, 1978.
Collert S: Osteomyelitis of the spine. Acta Orthop Scand 48:283–290, 1977.
Craig JB: Cervical spine osteomyelitis with delayed onset tetraparesis after penetrating wounds of the neck. S Afr Med J 69:197–199, 1986.
D’Elia JA, Coopan R, Younger D, Schoenbaum S, Freidberg S: Letter to the Editor. JAMA 241:29, 1979.
Deveraux MD, Hazelton RA: Pyogenic spinal osteomyelitis—Its clinical and radiologic presentation. J Rheumatol 10:491–493, 1983.
Digby JM, Kersley JB: Pyogenic nontuberculous spinal infection: An analysis of thirty cases. J Bone Joint Surg 61B:47–55, 1979.
Dutt A, Moers D, Stead WW: Short course chemotherapy for extrapulmonary tuberculosis. Ann Intern Med 104:7–12, 1986.
Editoral. Lancet 2, 137–138, 1974.
Eismont FJ, Bohlman HH, Soni PL, Goldberg M, Freehafer AA: Pyogenic and fungal vertebral osteomyelitis with paralysis. J Bone Joint Surg 65 A: 19–29, 1983.
Forlenza SW, Axelrod JL, Grieco MH: Pott’s disease in heroin addicts. JAMA 241:379–380, 1979.
Forsythe M, Rothman RH: New concepts in the diagnosis and treatment of infections of the cervical spine. Orthop Clin North Am 9:1039–1051, 1978.
Frederickson B, Yuan H, Olan R: Management and outcome of pyogenic vertebral osteomyelitis. Clin Orthop 131:160–167, 1978.
Freehafer AA, Furey JG, Pierce DS: Pyogenic osteomyelitis of the spine resulting in spinal paralysis. J Bone Joint Surg 44A:710–716, 1962.
Garcia A, Grantham SA: Hematogenous pyogenic vertebral osteomyelitis. J Bone Joint Surg 42A:429–436, 1960.
Garrido E, Rosenwasser RH: Experience with the suction-irrigation technique in the management of spinal epidural infection. Neurosurgery 12(6):678–679, 1983.
Genster HG, Anderson MJF: Spinal osteomyelitis complicating urinary tract infection. J Urol 107:109–111, 1972.
Glasgow MMS: Brucellosis of the spine. Br J Surg 63:283–288, 1976.
Gold RH, Bassett LW: Radionuclide evaluation of skeletal metastases: Practical considerations. Skeletal Radiol 15:1–9, 1986.
Gorse GJ, Pais MJ, Kusske JA, Cesario TC: Tuberculous spondylitis: A report of six cases and a review of the literature. Medicine 62:178–193, 1983.
Griffiths DL: Tuberculosis of the spine: A review. Adv Tuberc Res 29:92–110, 1980.
Griffiths HED, Jones DM: Pyogenic infection of the spine. A review of twenty-eight cases. J Bone Joint Surg 53B:383–391, 1971.
Haddon WA, Swanson AJG: Spinal infection caused by acupuncture mimicking prolapsed intervertebral disc. J Bone Joint Surg 64A:624–626, 1982.
Harries B: Spinal cord compression I, II. Br Med J 1:611–614, 673–676, 1970.
Hayes WS, Berg RA, Dorfman HD, Freedman MT: Case report. Skeletal Radiol 12:284–287, 1984.
Henson SW, Coventry MB: Osteomyelitis of the vertebrae as the result of infection of the urinary tract. Surg Gynecol Obstet 102:207–214, 1956.
Hirschmann JV, Everett ED: Candida vertebral osteomyelitis. J Bone Joint Surg 58A:573–575, 1976.
Hodgson AR, Yau A, Kwon JS, Kim D: Clinical study of 100 consecutive cases of Pott’s paraplegia. Clin Orthop 00:128–150, 1964.
Holzman RS, Bishko F: Osteomyelitis in heroin addicts. Ann Intern Med 75:693–696, 1971.
Jaffe HL: Metabolic, Degenerative, and Inflammatory Diseases of Bones and Joints. Philadelphia, Lea & Febiger, 1972.
Jordan MC, Kirby WM: Pyogenic vertebral osteomyelitis. Arch Intern Med 128:405–410, 1971.
Kahn DS, Pritzker KPM: The pathophysiology of bone infection. Clin Orthop 96:12–19, 1973.
Kashimoto T, Kitagawa H, Kachi H: Candida tropicalis vertebral osteomyelitis and discitis. Spine 11:57–61, 1986.
Kattapuram SV, Phillips WC, Boyd R: CT in pyogenic osteomyelitis of the spine. AJR 140:1199–1201, 1983.
Kemp HB, Jackson JW, Jeremiah JD, Hall AJ: Pyogenic infections occurring primarily in intervertebral disks. J Bone Joint Surg 55B:698–714, 1960.
King DM, Mayo KM: Infective lesions of the vertebral column. Clin Orthop 96:248–253, 1973.
Kornberg M, Rechtine GR, Dupy TE: Unusual presentation of spinal osteomyelitis: A changing disease. Spine 10:104–107, 1985.
Kulowski J: Pyogenic osteomyelitis of the spine. J Bone Joint Surg 18:343–364, 1936.
Laredo JD, Reizine D, Bard M, Merland JJ: Vertebral hemangiomas: Radiologic evaluation. Radiology 161:183–189, 1986.
Larde D, Mathieu D, Frija J, Gaston A, Vasile W: Vertebral osteomyelitis. Disk hypotensity on CT. AJR 139:963–967, 1982.
Leigh TF, Kelly RP, Weens HS: Spinal osteomyelitis associated with urinary tract infections. Radiology 65:334–342, 1955.
Leonard A, Comty CM, Shapiro FL, Raij L: Osteomyelitis in hemodialysis patients. Ann Intern Med 78:651–658, 1973.
Levack B, Kernohan J, Edgar MA, Ransford AO: Observations on the current and future surgical management of hydatid disease affecting the vertebrae. Spine 11:583–590, 1986.
Lewis RP, Sutter VL, Finegold SM: Bone infections involving anaerobic bacteria. Medicine 57:279–302, 1978.
Lichenstein L: Disease of Bone and Joints. St. Louis, CV Mosby, 1975.
LiFeso RM, Harder E, McCorkell SJ: Spinal brucellosis. J Bone Joint Surg 67B:345–351, 1985.
Masters DL, Lentino JR: Cervical osteomyelitis related to Nocardia aSteroides. J Infect Dis 149:824–825, 1984.
Matsushita T, Suzuki K: Spastic paraparesis due to cryptococcal osteomyelitis. Clin Orthop 196:279–284, 1985.
Matthai WH, Weikel CS, McDermott AM, Wenzel RP: Streptococcus bovis endocarditis with vertebral osteomyelitis. South Med J 79:1192–1193, 1986.
McHenry MC, Alfidi RJ, Wilde AH, Hawk WA: Hematogenous osteomyelitis: A changing disease. Cleve Clin Q 42:125–153, 1975.
McKee DF, Barr WM, Bryan CS, Lunceford EM Jr: Primary aspergillosis of the spine mimicking Pott’s paraplegia. J Bone Joint Surg 66A:1481–1483, 1981.
Medical Research Council: Controlled trial of anterior spinal fusion and debridement in the surgical management of tuberculosis of the spine in patients on standard chemotherapy: A study in Hong Kong. Br J Surg 61:853–866, 1974.
Mintz L, Mollett GH: Serratia vertebral osteomyelitis in narcotic addicts. Ann Intern Med 83:668–677, 1975.
Modic MT, Feiglin DH, Piraino DW, Boumphrey F, Weinstein MA, Duchesneau PM, Rehm S: Assessment of vertebral osteomyelitis using MR. Radiology 157:157–166, 1985.
Moxley GF, Moffatt TL, Falls WF: Hemodi-alysis-related osteomyelitis. South Med J 73:376–378, 1980.
Muhle I, Rav J, Ruskin J: Vertebral osteomyelitis due to Actinobacillus actinomycetencomitans. JAMA 241:1824–1825, 1979.
Musher DM, Fletcher T: Tolerant Staphylococcus aureus causing vertebral osteomyelitis. Arch Intern Med 142:632–634, 1982.
Mucher DM, Thorsteinsson SB, Minuth JN, Luchi RL: Vertebral osteomyelitis: Still a diagnostic pitfall. Arch Intern Med 136:105–110, 1976.
Nasca RJ, McElvein RB: Aspergillus fumigatus osteomyelitis of the thoracic spine treated by excision and interbody fusion. Spine 10:848–850, 1985.
Ninet J, Gayet JL, Etienne J, Bonvoisin B, Vignon E, Berthou JD, Delahaye JP, Pasquier J, Delaye J, Normand J: Bacterial endocarditis presenting as acute vertebral osteomyelitis: 14 cases. Eur Hear J 5(suppl C): 101–105, 1984.
Parke WW: Applied anatomy of the spine, The Spine, Rothman RH, Simeone FA (eds). Philadelphia, WB Saunders, 1980.
Parker MA, Tuazon CV: Cervical osteomyelitis. JAMA 240:50–51, 1978.
Petty BG, Burrow CR, Robinson RA, Bulkley GA: Hemophilus aphrophilus meningitis followed by vertebral osteomyelitis and suppurative psoas abscess. Am J Med 78:159–162, 1985.
Prossor IM, Merkel KD, Fitzgerald RH Jr, Brown ML: Roentgenograph and radionuclide detection of musculoskeletal sepsis, in Musculoskeletal Infections, Hughes SPF, Fitzgerald RH Jr (eds). Chicago, Year Book Medical Publishers, 1986.
Raff MJ, Melo JC: Anaerobic osteomyelitis. Medicine 57:83–103, 1978.
Ratcliffe JF: Anatomic basis for the pathogenesis and radiologic features of vertebral osteomyelitis and its differentiation from childhood discitis. Acta Radiol (Diagn) 26:137–143, 1985.
Ratcliffe JF: Arterial changes in the human vertebral body associated with aging. Spine 11:235–240, 1986.
Ray MJ, Bassett RL: Pyogenic vertebral osteomyelitis. Orthopedics 8:506–513, 1985.
Relier LB: The serum bactericidal test. Rev Infect Dis 8:803–806, 1986.
Robbins N, Wisoff HS, Klein RS: Case report: Vertebral osteomyelitis caused by Streptococcus bovis. Am J Med Sci 291:128–129, 1986.
Roca RP, Yoshikawa TT: Primary skeletal infections in heroin users. Clin Orthop 144:238–247, 1979.
Roselle GA, Baird IM: Aspergillus flavus group osteomyelitis. Arch Intern Med 139:590–592, 1979.
Ross PM, Fleming JL: Vertebral body osteomyelitis: Spectrum and natural history. Clin Orthop 118:190–198, 1976.
Rowlings CE, Wilkins RH, Gallis HA, Goldner JL, Francis R: Postoperative intervertebral disc space infection. Neurosurgery 13:371–376, 1983.
Sapico F, Montgomery JL: Pyogenic vertebral osteomyelitis: Report of nine cases and review of the literature. Rev Infect Dis 5:754–776, 1979.
Seligsohn R, Rippon JW, Lerner SA: Aspergillus terreus osteomyelitis. Arch Intern Med 137:918–920, 1977.
Silberstein HB, Schneider HJ, Khodadad J, DeVries D, Rauf C: Laminectomy: Effects on postoperative technetium and gallium scintigraphy. Radiology 151:785–787, 1984.
Slagel S, Skiendzielewski JJ, McMurry FG: Osteomyelitis of the cervical spine: Reversible quadraplegia resulting from Philadelphia collar placement. Ann Emerg Med 14:912–915, 1985.
Smith MA, Trowers NRH, Klein RS: Cervical osteomyelitis caused by Pseudomonas cepacia in an intravenous drug abuser. J Clin Microbiol 21:445–446, 1985.
Stauffer RN: Pyogenic vertebral osteomyelitis. Orthop Clin North Am 6(4): 1015–1026, 1975.
Stone DB, Bonfiglio M: Pyogenic vertebral osteomyelitis. Arch Intern Med 112:491–500, 1963.
Thomas PH, Allai J, Bontoux D, Rossi F, Poupet JY, Petitalot JP, Becq-Giraudon B: Rheumatologie manifestations of infective endocarditis Ann Rheum Dis 43:716–720, 1984.
Turek SL: Orthopedics. Philadelphia, Lippincott, 1984.
Waisbren BA: Pyogenic osteomyelitis and arthritis of the spine treated with combinations of antibiotics and gamma globulin. J Bone Joint Surg 42A.414–429, 1960.
Waldvogel FA: Treatment of osteomyelitis and septic arthritis. Bull NY Acad Med 58:733–749, 1982.
Waldvogel FA, Medoff G, Swartz MN: Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med 282:198–206, 260–266, 316–322, 1970.
Waldvogel FA, Vasey H: Osteomyelitis: The past decade. N Engl J Med 303:360–370, 1980.
Watanakunakorn C, Trott A: Vertebral osteomyelitis due to Mycobacterium kansasii. Am Rev Respir Dis 107:846–853, 1973.
Wear JB, Baylin GJ, Martin TL: Pyogenic vertebral osteomyelitis of the spine. Am J Roentgenol, Rad Ther Nucl Med 67:90–94, 1952.
Weaver P, Lifeso RM: The radiologic diagnosis of tuberculosis of the adult spine. Skeletal Radiol 12:178–186, 1984.
Wedge JH, Oryschak AF, Robertson DE, Kirkaldy-Willis WH: Atypical manifestation of spinal infections. Clin Orthop 123:155–163, 1977.
Wiley AM, Trueta J: The vascular anatomy of the spine and its relationship to pyogenic vertebral osteomyelitis. J Bone Joint Surg 41:796–809, 1959.
Witorsch P, Utz JP: North American blastomycosis: A study of forty patients. Medicine 47:169–200, 1968.
Wright RL: Infections of the spine and spinal cord, in Neurological Surgery, Youmans JR (ed). Philadelphia, WB Saunders, 1982.
Yanoff DB, Church ML: Nocardial vertebral osteomyelitis. Clin Orthop 175:223–226, 1983.
Young EJ: Human brucellosis. Rev Infect Dis 5:821–842, 1983.
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Piercy, E.A., Smith, J.W. (1988). Vertebral Osteomyelitis. In: Schlossberg, D. (eds) Orthopedic Infection. Clinical Topics in Infectious Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3870-6_3
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