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Antibiotics in Orthopedic Infections

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Orthopedic Infection

Part of the book series: Clinical Topics in Infectious Disease ((CLIN.TOP.INFECT))

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Abstract

The clinician dealing with orthopedic infections must be familiar with the pathogens associated with bone and joint infections, and must also know the spectrum, pharmacokinetics, side effects, and cost of antibiotics used to prevent or treat such infections. The treatment of bone and joint infections is a special situation that requires additional considerations in the selection of an appropriate antibiotic. The use of a few antibiotics is appropriate for the great majority of bone and joint infections. The clinician should become familiar with the most cost-effective antibiotics for various situations and refrain from constantly changing antibiotics in hopes of better results.

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References

  1. Brause BD: Infection associated with prosthetic joints. Clin Rheum Dis 12:523–536, 1986.

    PubMed  CAS  Google Scholar 

  2. Burke JF: The effective period of preventative antibiotic action in experimental incisions and dermal lesions. Surgery 50:161, 1961.

    PubMed  CAS  Google Scholar 

  3. Coventry MB: Treatment of infections occurring in total hip surgery. Orthop Clin North Am 6:991–1003, 1975.

    PubMed  CAS  Google Scholar 

  4. Cunha BA: Antibiotic tissue penetration. Bull NY Acad Med 59:443–449, 1983.

    CAS  Google Scholar 

  5. Cunha BA: Antibiotics dosing in the elderly patient, in Infectious Diseases of the Elderly, Cunha BA (ed). London, John Wright & Co, 1988.

    Google Scholar 

  6. Cunha BA (ed): Antimicrobial therapy. Med Clin North Am 66:1–313, 1982.

    Google Scholar 

  7. Cunha BA: Clinical uses of the tetracyclines, in The Tetracyclines, Boothe JH, Hlavka JH (eds). Berlin, Springer-Verlag, 1985.

    Google Scholar 

  8. Cunha BA: Drug fever. Postgrad Med 80:123–129, 1986.

    PubMed  CAS  Google Scholar 

  9. Cunha BA: Infectious complications in orthopedic surgery: musculoskeletal infections. ADIS Press 3:1–47, 1983.

    Google Scholar 

  10. Cunha BA: The use of penicillins in orthopedic surgery. Clin Orthop 190:36–49, 1984.

    PubMed  Google Scholar 

  11. Cunha BA: Therapy with cefonicid: an overview of clinical applications. Adv Ther 2:177–191, 1985.

    Google Scholar 

  12. Cunha BA: Third Generation Cephalosporins. Metuchen, NJ, Health Communication Press, 1985.

    Google Scholar 

  13. Cunha BA: Vancomycin, in Antimicrobial Therapy, Ristuccia AM, Cunha BA (eds). New York, Raven Press, 1984.

    Google Scholar 

  14. Cunha BA, Gossling HR, Nightingale C, Quintiliani R: Penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement. J Bone Joint Surg 59A:856–860, 1977.

    Google Scholar 

  15. Cunha BA, Gossling HR, Nightingale CH, Quintiliani R: Penetration of cefazolin and cefradine into bone in patients undergoing total knee arthroplasty. Infection 2:80–84, 1984.

    Article  Google Scholar 

  16. Cunha BA, Nightingale CH, Quintiliani R: The pharmacokinetics of prophylactic antibiotics in cardiovascular and orthopedic surgery. Clin Ther 2:221–223, 1979.

    Google Scholar 

  17. Eisenberg JM, Kitz DS: Savings from outpatient antibiotic therapy for osteomyelitis. JAMA 255:1584–1588, 1986.

    Article  PubMed  CAS  Google Scholar 

  18. Fitzgerald RH Jr: Experimental osteomyelitis: description of a canine model and the role of depot administration of antibiotics in the prevention and treatment of sepsis. J Bone Joint Surg 65A:371–380, 1983.

    Google Scholar 

  19. Fitzgerald RH Jr: The infected hip arthroplasty: current concepts in treatment, in The Hip, Welch R (ed). St. Louis, CV Mosby, 1984, p 347.

    Google Scholar 

  20. Fitzgerald RH Jr: Problems associated with infected total hip arthroplasty. Clin Rheum Dis 12:537–554, 1986.

    PubMed  Google Scholar 

  21. Fitzgerald RH Jr, Bechtol CO, Eftekhar N, et al: Reduction of deep sepsis after total hip arthroplasty. Arch Surg 114:803-804, 1979.

    PubMed  Google Scholar 

  22. Fitzgerald RH Jr, Brewer NS, Dahlin DC: Squamous-cell carcinoma complicating chronic osteomyelitis. J Bone Joint Surg 58A: 1146–1148, 1976.

    Google Scholar 

  23. Fitzgerald RH Jr, Nolan DR, Ilstrup DM, et al: Deep wound sepsis following total hip arthroplasty. J Bone Joine Surg 59A:847–855, 1977.

    Google Scholar 

  24. Fitzgerald RH Jr, Peterson LFA, Washington JA II, et al: Bacterial colonization of wounds and sepsis in total hip arthroplasty. J Bone Joint Surg 55A: 1242–1250, 1973.

    Google Scholar 

  25. Goldenberg DL, Brandt KD, Cathcart ES, et al: Acute arthritis caused by gram-negative bacilli: a clinical characterization. Medicine 53:197–208, 1974.

    Article  PubMed  CAS  Google Scholar 

  26. Goldenberg DL, Brandt KD, Cohen AS, et al: Treatment of septic arthritis: comparison of needle aspiration and surgery as initial modes of joint drainage. Arthritis Rheum 18:83–90, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Hirschmann JV, Inui TS: Antimicrobial prophylaxis: critique of recent trials. Rev Infect Dis 2:1, 1981.

    Article  Google Scholar 

  28. Hughes SPF, Fitzgerald RH Jr: Musculoskeletal Infections. Chicago, Year Book Medical Publishers, 1987.

    Google Scholar 

  29. Kelly PJ: Bacterial arthritis in the adult. Ort hop Clin North Am 6:973–981, 1975.

    CAS  Google Scholar 

  30. Kelly PJ: Infections of the spine, in Spinal Disorders, Diagnosis and Treatment, Ruge D, Wiltse L (eds). Philadelphia, Lea & Febiger, 1977.

    Google Scholar 

  31. Kelly PJ, Martin WJ, Coventry MB: Bacterial (suppurative) arthritis in the adult. J Bone Joint Surg 52A: 1595–1602, 1970.

    Google Scholar 

  32. Kunkel MJ, Iannini PB: Cefonicid in a once-daily regimen for treatment of osteomyelitis in an ambulatory setting. Rev Infect Dis 6(Suppl):S865–S869, 1984.

    Article  PubMed  Google Scholar 

  33. Mader JT, Cierny G III: The principles of the use of preventive antibiotics. Clin Orthop 190:75–83, 1984.

    PubMed  Google Scholar 

  34. Monson TP, Nelson CL: Microbiology for orthopaedic surgeons: selected aspects. Clin Orthop 190:14–23, 1984.

    PubMed  Google Scholar 

  35. Nelson JD: Antibiotic concentrations in septic joint effusions. N Engl J Med 284:349–353, 1971.

    Article  PubMed  CAS  Google Scholar 

  36. Nelson JP: Deep infection following total hip arthroplasty. J Bone Joint Surg 59A: 1042–1044, 1977.

    Google Scholar 

  37. Neu HC: Cephalosporin antibiotics as applied in surgery of bones and joints. Clin Orthop 190:50–66, 1984.

    PubMed  Google Scholar 

  38. Norden CW, Bryant R, Palmer D, Montgomerie JZ, Wheat J: Chronic osteomyelitis caused by Staphylococcus aureus: controlled clinical trial of nafcillin therapy and nafcillin-rifampin therapy. South Med J 79:947–951, 1986.

    Article  PubMed  CAS  Google Scholar 

  39. Norden CW, Shaffer M: Treatment of experimental chronic osteomyelitis due to Staphylococcus aureus with vancomycin and rifampin. J Infect Dis 147:352–357, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Patzakis M J (ed): Antibiotics in orthopaedics. Clin Orthop 190:2–114, 1984.

    Google Scholar 

  41. Patzakis MJ, Harvey JP, Tyler D: The role of antibiotics in the management of open fractures. J Bone Joint Surg 56A:532, 1974.

    Google Scholar 

  42. Poretz DM, Eron LD, Goldenberg RI, et al: Intravenous antibiotic therapy in an outpatient setting. JAMA 248:336–339, 1982.

    Article  PubMed  CAS  Google Scholar 

  43. Rehm SJ, Weinstein AJ: Home intravenous antibiotic therapy: a team approach. Ann Intern Med 99:388–392, 1983.

    PubMed  CAS  Google Scholar 

  44. Salvati EA, Brause BD, Chekofsky KM, et al: Reimplantation in infection: an eleven year experience. Orthop Trans 5:370, 1981.

    Google Scholar 

  45. Swanberg L, Tuazon C: Rifampin in the treatment of serious staphylococcal infections. Am J Med Sci 287:49–54, 1984.

    Article  PubMed  CAS  Google Scholar 

  46. Ullman RF, Cunha BA: Antibiotic selection in the penicillin allergic patient. Intern Med 7:100–106, 1986.

    Google Scholar 

  47. Waldvogel FA, Medoff G, Swartz MN: Osteomyelitis: a review of clinical features, therapeutic considerations, and unusual aspects. N Engl J Med 382:198–206, 260–266, 312–322, 1970.

    Article  Google Scholar 

  48. Waldvogel FA, Vasey H: Osteomyelitis: the past decade. N Engl J Med 303:360–370, 1980.

    Article  PubMed  CAS  Google Scholar 

  49. Weisseman GJ, Wood VE, Kroll LL: Pseudomonas vertebral osteomyelitis in heroin addicts. J Bone Joint Surg 55 A: 1416–1424, 1973.

    Google Scholar 

  50. Williams DN, Gustilo RB, Beverly R, Kind AC: Bone and serum concentrations of five cephalosporin drugs: relevance to prophylaxis and treatment in orthopedic surgery. Clin Orthop 179:253–265, 1983.

    PubMed  Google Scholar 

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Authors
  1. Burke A. Cunha
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Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Medicine, Episcopal Hospital, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1988 Springer-Verlag New York Inc.

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Cunha, B.A. (1988). Antibiotics in Orthopedic Infections. In: Schlossberg, D. (eds) Orthopedic Infection. Clinical Topics in Infectious Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3870-6_12

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  • DOI: https://doi.org/10.1007/978-1-4612-3870-6_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8383-6

  • Online ISBN: 978-1-4612-3870-6

  • eBook Packages: Springer Book Archive

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