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Infection of Orthopedic Prostheses

  • Chapter
Orthopedic Infection

Part of the book series: Clinical Topics in Infectious Disease ((CLIN.TOP.INFECT))

Abstract

The widespread use of total joint replacements has brought the problem of complicating sepsis to the fore. In contrast to the highly successful outcome of such surgery when uncomplicated, the development of deep infection leads to pain and septic loosening, which generally requires extensive surgery and removal of the prosthesis, leaving large skeletal defects, significant extremity shortening, and marked disability (14).

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References

  1. Agins HJ et al: A histologic and quantitative analysis of metallic wear in failed titanium alloy/ ultra high molecular weight polyethylene (UHMWPE) total hip replacements. J Bone Joint Surg 70A:347–356, 1988.

    Google Scholar 

  2. Aglietti P, Salvati EA, Wilson PD Jr, Kutner LJ: Effect of surgical unidirectional filtered air-flow unit on wound bacterial contamination and wound healing. Clin Orthop 101:99, 1974.

    PubMed  Google Scholar 

  3. Ainskow DAP, Denham RA: the risk of haema-togenous infection in total joint replacements. J Bone Joint Surg 66B:580, 1984.

    Google Scholar 

  4. Berman AT, Johnson MD III: The use of the Hickman catheter in orthopaedic infections. J Bone Joint Surg 67A:650, 1985.

    Google Scholar 

  5. Blomgren G, Lindgren V: Hoematogenous infection, in Revision Arthroplasty 2, Elson RA (ed). London, Franklin Scientific Publications, 1983, pp 46–49.

    Google Scholar 

  6. Bourne RB, Hunter GA, Rorabeck CH, Macnab JJ: A six year follow-up of infected total hip replacements managed by Girdlestone’s arthroplasty. J Bone Joint Surg 66B:340, 1984.

    Google Scholar 

  7. Burke JF, The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery 50:161–168, 1961.

    PubMed  CAS  Google Scholar 

  8. Callaghan JJ, Salvati EA, Brause BD, Rimnac CM, Wright TM: Reimplantation for salvage of the infected hip: rationale for the use of gentamicin-impregnated cement and beads, in The Hip: Proceedings of Fourteenth Open Scientific Meeting of The Hip Society. St. Louis, CV Mosby 1986, pp 65–94.

    Google Scholar 

  9. Capello WN, Uri BG, Wellman, HN, Robb JA, Stiver PL: Comparison of radiographic and radionuclide hip arthrography in determination of femoral component loosening of hip arthroplasties, in The Hip: Proceedings of the Thirteenth Open Scientific Meeting of The Hip Society. St. Louis, CV Mosby, 1985, pp 157–168.

    Google Scholar 

  10. Charnley J: Low-friction Arthroplasty of the Hip: Theory and Practice. New York, Springer-Verlag, 1979.

    Google Scholar 

  11. Coleman DL, Horwitz RI, Andriole VT: Association between serum inhibitory and bactericidal concentration and therapeutic outcome in bacterial endocarditis. Am J Med 73:260, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Collins DN, Garvin KL, Nelson CL: The vastus lateralis flap as treatment for the intractably infected resection arthroplasty after hip implant. J Bone Joint Surg 11:221, 1987.

    Google Scholar 

  13. Deysine M, Rafkin H, Russell R, Teicher I, Aufses AH Jr: The detection of acute experimental osteomyelitis with 67 Ga citrate scannings. Surg Gynecol Obstet 141A:40, 1975.

    Google Scholar 

  14. Eftekhar NS: Infection in Joint Replacement: Prevention and Management. St. Louis, CV Mosby, 1984.

    Google Scholar 

  15. Fenelon GCC, Von Foerster G, Engelbrecht E: Disarticulation of the hip as a result of failed arthroplasty: a series of 11 cases. J Bone Joint Surg 62B:441, 1980.

    Google Scholar 

  16. Goulet JA, Pellicci PM, Brause BD, Salvati EA: Prolonged suppression of infection in total hip arthroplasty. To be published in the June Issue of J. Arthroplasty, Vol. 3, #2, pp. 109–116, 1988. February 20–25, 1986, p 131, No. 213.

    Google Scholar 

  17. Gristina AG, Costerton JW: Bacterial adherence to biomaterials and tissue: the significance of its role in clinical sepsis. J Bone Joint Surg 67A:264, 1985.

    Google Scholar 

  18. Hill C, Mazas F, Flamant R, Evrard J: Prophylactic cefazolin versus placebo in total hip replacement. Lancet 1:795, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Lidwell OM, Lowbury EJ, Whyte W, Blowers R, Stanley SJ, Lowe D: Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or total knee replacement: a randomized study. Br Med J (Clin Res) 285(6334): 10–14, 1982.

    Article  CAS  Google Scholar 

  20. Lim EVA, Stern P: Candida infection after implant arthroplasty: a case report. J Bone Joint Surg 68A:43, 1986.

    Google Scholar 

  21. Maurer AH, Chen DCP, Camargo EE, Wong DF, Wagner HN Jr, Alderson PO: Utility of three-phase skeletal scintigraphy in suspected osteomyelitis: concise communication. J Nucl Med 22:941–949, 1981.

    PubMed  CAS  Google Scholar 

  22. Merkel KD, Fitzgerald RH Jr, Brown ML: Scintigraphic examination of total hip arthroplasty: comparison of indium with gallium-technetium in the loose and infected canine arthroplasty. J Bone Joint Surg 67A:465, 1985.

    Google Scholar 

  23. O’Neil DA, Harris WH: Failed total hip replacement: assessment by plain radiographs, arthrogram, and aspiration of the hip joint. J Bone Joint Surg 66A:540, 1984.

    Google Scholar 

  24. Parker RH, Schmid FR: Antibacterial activity of synovial fluid during therapy for septic arthritis. Arthritis Rheum 14:96, 1971.

    Article  PubMed  CAS  Google Scholar 

  25. Perry CR, Davenport K, Vossen MK: Local delivery of antibiotics via an implantable pump in the treatment of osteomyelitis. Clin. Orthop. 226:222, 1988.

    PubMed  Google Scholar 

  26. Petty W: Quantitative determination of the effect of antimicrobial irrigating solutions on bacterial contamination of experimental wound. J Bone Joint Surg 67A:1236, 1985.

    Google Scholar 

  27. Petty W, Spanier S, Shuster JJ, Silverthorne C: The influence of skeletal implants on incidence of infection: experiments in a canine model. J Bone Joint Surg 67A:1236, 1985.

    Google Scholar 

  28. Propst-Proctor SL, Dillingham MF, McDougall IR, Goodwin D: The white blood cell scan in orthopaedics. Clin Orthop 168:157, 1982.

    PubMed  Google Scholar 

  29. Rae T: The toxicity of metals used in orthopaedic prostheses: an experimental study using cultured human synovial fibroblasts. J Bone Joint Surg 63B:435–440, 1981.

    Google Scholar 

  30. Riordan T, Doyle D, Tabaqchali S: Synovial fluid lactic acid measurement in the diagnosis and management of septic arthritis. J Clin Pathol 35:390–394, 1982.

    Article  PubMed  CAS  Google Scholar 

  31. Rushton N, Coakley AJ, Tudor J, Wraight EP: The value of technetium and gallium scanning in assessing pain after total hip replacement. J Bone Joint Surg 64B.313, 1983.

    Google Scholar 

  32. Salvati EA, Callaghan JJ, Brause BD, Klein RF, Small RD: Reimplantation in infection: elution of gentamicin from cement and beads. Clin Orthop 207:83, 1986.

    PubMed  Google Scholar 

  33. Salvati EA, Ghelman B, McLaren T, Wilson PD Jr: Subtraction technique in arthrography for loosening of total hip replacement fixed with radiopaque cement. Clin Orthop 101:105, 1974.

    PubMed  Google Scholar 

  34. Salvati EA, Robinson RP, Zeno SM, Koslin BL, Brause BD, Wilson PD Jr: Infection rates after 3175 total hip and total knee replacements performed with and without a horizontal unidirectional filtered air-flow system. J Bone Joint Surg 64A:525, 1982.

    Google Scholar 

  35. Salvati EA, Small RD, Brause BD, Pellicci PM: Infections associated with orthopedic devices, in Infections Associated with Prosthetic Devices, Sugarman B, Young EJ (eds). Boca Raton, FL, CRC Press, 1984.

    Google Scholar 

  36. Sandusky WR: Use of prophylactic antibiotics in surgical patients. Surg Clin N Am 60(1):83, 1980.

    PubMed  CAS  Google Scholar 

  37. Schurman DJ, Hirshman HP, Kajiyama G, Moser K, Burton DS: Cefazolin concentrations in bone and synovial fluid. J Bone Joint Surg 60A:359, 1978.

    CAS  Google Scholar 

  38. Small CB, Slater LN, Lowy FD, Small RD, Salvati EA, Casey JI: Group B streptococcal arthritis in adults. Am J Med 76:367, 1984.

    Article  PubMed  CAS  Google Scholar 

  39. Soave R, Hirsch J, Salvati EA, Brause BD, Roberts RB: Comparison of ceforanide and cephalothin prophylaxis in patients undergoing total joint arthroplasty. Orthopaedics 9:1657, 1986.

    CAS  Google Scholar 

  40. Vaudaux P, Suzuki R, Waldvogel FA, Morgenthaler JJ, Nydegger UE: Foreign-body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus. J Infect Dis 150:546, 1984.

    Article  PubMed  CAS  Google Scholar 

  41. Vaudaux PE, Waldvogel FA, Morgenthaler JJ, Nydegger UE: Absorption of fibronectin onto polymethylmethacrylate and promotion of Staphylococcus aureus adherence. Infect Immun 45:168, 1984.

    Google Scholar 

  42. Von Essen R, Holtta A: Improved method of isolating bacteria from joint fluids by the use of blood culture bottles. Ann Rheum Dis 45:454, 1986.

    Article  Google Scholar 

  43. Wiggins CE, Nelson CL, Clarke R, Thompson CH: Concentration of antibiotics in normal bone after intravenous injection. J Bone Joint Surg 60A:93, 1978.

    CAS  Google Scholar 

  44. Wilson, FC, Worchester NN, Coleman PD, Byrd, WE: Antibiotic penetration of experimental bone hematomas. J Bone Joint Surg 53A:1622, 1971.

    Google Scholar 

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Authors
  1. Eduardo A. Salvati
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  2. Barry D. Brause
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Medicine, Episcopal Hospital, Philadelphia, Pennsylvania, 19125, USA

    David Schlossberg M.D., F.A.C.P. (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1988 Springer-Verlag New York Inc.

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Salvati, E.A., Brause, B.D. (1988). Infection of Orthopedic Prostheses. In: Schlossberg, D. (eds) Orthopedic Infection. Clinical Topics in Infectious Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3870-6_10

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  • DOI: https://doi.org/10.1007/978-1-4612-3870-6_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8383-6

  • Online ISBN: 978-1-4612-3870-6

  • eBook Packages: Springer Book Archive

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