Acute osteomyelitis is a rapidly progressing infection of bone, involving the medullary cavity, the cortex, and/or the periosteum. The term “acute” is used here in opposition to “chronic osteomyelitis,” a situation in which the same organisms usually produce long-standing infection of bones characterized by persistence of microorganisms and low-grade inflammation, presence of dead bone (sequestra), fistulae, and anarchic bone proliferation (bone sclerosis). Although the terms “acute” and “chronic” are used somewhat loosely and do not have a sharp demarcation, they are useful concepts in infectious diseases, since they define two clinical situations with different clinical presentations, outcomes, and therapies despite their common etiology and pathogenesis.
KeywordsMeningitis Vancomycin Gentamicin Candida Polymethylmethacrylate
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