Bioaccumulation Behavior of Persistent Organic Chemicals with Aquatic Organisms

  • Des W. Connell
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 102)


Chemicals are a vital part of everyday life. They come in the form of fuels, antibiotics, pesticides, plastic containers, agricultural fertilizers, photocopying compounds, and so on. Society cannot survive in its present form without them. Growth in the numbers of chemicals used during recent decades has been extraordinary. In 1980 the total number of substances commercially available was estimated at 40,000 with about 2000 new ones being placed on the market each year (Schmidt-Bleek and Haberland 1980).


Partition Coefficient Aquatic Organism Lipophilic Compound Bioconcentration Factor Water Partition Coefficient 
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  1. Addison RF (1976) Organochlorine compounds in aquatic organisms: their distribution, transport and physiological significance. In Lockwood APM (ed) Effects of pollutants on aquatic organisms. Cambridge University Press, Cambridge, p 127.Google Scholar
  2. Anliker R, Clarke EA, Moser P (1981) Use of partition coefficient as an indicator of bioaccumulation tendency of dyestuffs in fish. Chemosphere 10:263–274.CrossRefGoogle Scholar
  3. Anliker R, Moser P (1987) The limits of bioaccumulation of organic pigments in fish: their relation to the partition coefficient and the solubility in water and octanol. Ecotoxicol Environ Safety 13:43–52.PubMedCrossRefGoogle Scholar
  4. Atkins GL (1969). Multicompartment Models for Biological Systems. Methuen, London.Google Scholar
  5. Bahner LH, Wilson AJ, Sheppard JM, Patrick JM, Goodman LR, Walsh GE (1977) Kepone bioconcentration, accumulation, loss and transfer through estuarine food chains. Chesapeake Sci 18:299–308.CrossRefGoogle Scholar
  6. Baughman GL, Paris DF (1981) Microbial bioconcentration of organic pollutants from aquatic systems—a critical review. CRC Crit Rev Microbiol January 205–227.Google Scholar
  7. Briggs GG (1981) Theoretical and experimental relationships between soil adsorption, octanol-water partition coefficients, water solubility, bioconcentration factors and the parachor. J. Agric Food Chem 29:1050–1059.CrossRefGoogle Scholar
  8. Brookes DN, Dobbs AJ, Williams N (1986) Octanol: water partition coefficients (P): measurement, estimation and interpretation, particularly for chemicals with P > 105. Ecotoxicol Environ Safety 11:251–260.CrossRefGoogle Scholar
  9. Bruggerman WA, Marton LBJM, Kooiman D, Hutzinger O (1981) Accumulation and elimination kinetics of di-, tri-and tetra chlorobiphenyls by goldfish after dietry exposure. Chemosphere 10:811–832.CrossRefGoogle Scholar
  10. Bryan GW (1979) Bioaccumulation of marine pollutants. Phil Trans Royal Soc Lond B 286:483–505.CrossRefGoogle Scholar
  11. Canton JH, Greve PA, Slooff W, van Esch GJ (1975) Toxicity, accumulation and elimination studies of hexachlorocyclohexane with freshwater organisms of different trophic levels. Water Res 9:1163–1169.CrossRefGoogle Scholar
  12. Chadwick GG, Brocksen RW (1969) Accumulation of dieldrin by fish and selected fish-food organisms. J Wildlife Manag 33:693–700.CrossRefGoogle Scholar
  13. Chiou CT (1985) Partition coefficients of organic compounds in lipid-water systems and correlations with fish bioconcentration factors. Environ Sci Technol 19:57–62.CrossRefGoogle Scholar
  14. Chiou CT, Freed VH, Schmedding DW, Kohnert RL (1977) Partition coefficients and bioaccumulation of selected organic chemicals. Environ Sci Technol 11:475–478.CrossRefGoogle Scholar
  15. Connell DW (1978) A kerosene-like taint in the sea mullet. II Some aspects of the deposition and metabolism of hydrocarbons in muscle tissue. Bull Environ Contam Toxicol 20:492–498.PubMedCrossRefGoogle Scholar
  16. Connell DW, Miller GJ (1984) Chemistry and ecotoxicology of pollution. John Wiley and Son, New York, p 181.Google Scholar
  17. Courtney WAM, Langston WJ (1978) Uptake of polychlorinated biphenyl (Aroclor 1254) from sediment and from seawater in two intertidal polychaetes. Environ Pollut 15:303–309.CrossRefGoogle Scholar
  18. Davies RP, Dobbs AJ (1984) The prediction of bioconcentration in fish. Water Res 18:1253–1262.CrossRefGoogle Scholar
  19. Dobroski CJ, Epifanio CE (1980) Accumulation of benzo(a) pyrene in a larval bivalve via trophic transfer. Can J Fish Aquat Sci 37:2318–2322.CrossRefGoogle Scholar
  20. Ellegenhausen H, Guth JA, Esser HO (1980) Factors determining the bioaccumulation potential of pesticides in the individual compartments of aquatic food chains. Ecotoxicol Environ Safety 4:134–157.CrossRefGoogle Scholar
  21. Ernst W (1977) Determination of the bioconcentration potential of marine organisms — a steady state approach. I. Bioconcentration data for seven chlorinated pesticides in mussels and their relation to solubility data. Chemosphere 11:731–740.CrossRefGoogle Scholar
  22. Esser HO, Moser P (1982) An appraisal of problems related to the measurement and evaluation of bioaccumulation. Ecotoxicol Environ Safety 6:13CrossRefGoogle Scholar
  23. Farrington JW, Goldberg ED, Risebrough JH, Martin JH, Bowen VT (1983) US Mussel Watch 1976-1978: An overview of the trace metal, DDE, PCB, hydrocarbon and radionuclide data. Environ Sci Technol 17:490–496.CrossRefGoogle Scholar
  24. Geyer H, Sheehan D, Kotzias D, Freitag D, Korte F (1982) Prediction of eco-toxicological behavior of chemicals: relationship between physicochemical properties and bioaccumulation of organic chemicals in the mussel. Chemosphere 11:1121–1134.CrossRefGoogle Scholar
  25. Geyer H, Scheunert T, Korte F (1985) Relationship between the lipid content offish and their bioconcentration potential of 1,2,4-trichlorobenzene. Chemosphere 14:545–555.CrossRefGoogle Scholar
  26. Gobas FAPC, Opperhuizen A, Hutzinger O (1986) Bioconcentration of hydrophobic chemicals in fish: relation with membrane permeation. Environ Toxicol Chem 5:637–646.CrossRefGoogle Scholar
  27. Goldbach RW, van Generen H, Leeuwangh P (1976) Hexachlorobutadiene residues in aquatic fauna from surface water fed by the River Rhine. Sci Total Environ 6:31–40.PubMedCrossRefGoogle Scholar
  28. Griesbach S, Peters RH, Youakim S (1982) An allornetric model for pesticide bio-accumulation. Can J Fish Aquat Sci 39:727–735.CrossRefGoogle Scholar
  29. Grzenda AR, Paris DF, Taylor WJ (1970) The uptake, metabolism and elimination of chlorinated residues by goldfish fed a DDT contaminated diet. Trans Am Fish Soc 99:385–396.CrossRefGoogle Scholar
  30. Hamelink JL, Waybrant RC, Ball C (1971) A proposal: Exchange equilibria control the degree chlorinated hydrocarbons are biologically magnified in lentic environments. Trans Am Fish Soc 100:207–214.CrossRefGoogle Scholar
  31. Hamelink JL, Spacie A (1977) Fish and chemicals: the process of accumulation. Ann Rev Pharmacol Toxicol 17:167–177.CrossRefGoogle Scholar
  32. Hansch C (1969) A quantitative approach to biochemical structure-activity relationships. Acc Chem Res 2:232–240.CrossRefGoogle Scholar
  33. Harding GCH (1977) Surface area of the euphasiid Thysanoessa raschii and its relation to body length, weight, and respiration. J Fish Res Bd Can 34:225–231.CrossRefGoogle Scholar
  34. Harding GCH, Vass WP (1978) Uptake from seawater of DDT by marine planktonic crustacea. J Fish Res Bd Can 36:247–254.CrossRefGoogle Scholar
  35. Harding GC, Vass WP, Drinkwater KF (1981) Importance of feeding, direct uptake from seawater, and transfer from generation to generation in the accumulation of an organochlorine (DDT) by the marine planktonic copepod. Can J Fish Aquat Sci 38:101–119.CrossRefGoogle Scholar
  36. Hawker DW, Connell DW (1985a) Prediction of bioconcentration factors under non-equilibrium conditions. Chemosphere 14:1835–1843.CrossRefGoogle Scholar
  37. Hawker DW, Connell DW (1985b) Relationships between partition coefficient, uptake rate constant, clearance rate constant and time to equilibrium for bio-accumulation. Chemosphere 14:1205–1219.CrossRefGoogle Scholar
  38. Hawker DW, Connell DW (1986) Bioconcentration of lipophilic compounds by some aquatic organisms. Ecotoxicol Environ Safety 11:184–197.PubMedCrossRefGoogle Scholar
  39. Hilton JW, Hodson PV, Braun HE, Leatherhead JL, Slinger SJ (1983) Contaminant accumulation and physiological response in the rainbow trout reared on naturally contaminated diets. Can J Fish Aquat Sci 40:1987–1994.CrossRefGoogle Scholar
  40. Hunn JB, Allen JL (1974) Movement of drugs across the gills of fish. Ann Rev Pharmacol 14:47–55.CrossRefGoogle Scholar
  41. Hunt ED, Bischoff AI (1960) Inimical effects on wildlife of periodic DDD applications to Clear Lake. Calif Fish Game 46:91–106.Google Scholar
  42. Isaacs JD (1973) Potential trophic biomasses and trace substance concentrations in unstructured marine food webs. Marine Biol 23:97–104.CrossRefGoogle Scholar
  43. Jury WA, Spencer WF, Farmer WJ (1983) Behavior assessment model for trace organics in soil: I. Model description. J. Environ Qual 12:558–564.CrossRefGoogle Scholar
  44. Karickhoff SW, Brown DS, Scott TA (1979) Sorption of hydrophobic pollutants on natural sediments and soils. Water Res 13:241–248.CrossRefGoogle Scholar
  45. Kenaga EE, Goring CA (1980) Relationship between water solubility, soil sorption, octanol-water partitioning and bioconcentration of chemicals in biota. In: Eaton JG, Parrish PR, Hendricks AC (ed) Aquatic Toxicology, Vol. 707, ASTM, Philadelphia pp 78–115.CrossRefGoogle Scholar
  46. Kenaga EE (1972) Chlorinated hydrocarbon insecticides in the environment: factors related to bioconcentration of pesticides. In: Matsumura F, Boush GM, Misato T (eds) Environmental toxicology of pesticides. Academic Press, New York pp 193–228.Google Scholar
  47. Kenaga EE (1980) Predicted bioconcentration factors and soil sorption coefficients of pesticides and other chemicals. Ecotoxicol Environ Safety 4:26–38.PubMedCrossRefGoogle Scholar
  48. Kerr SR, Vass WP (1973) Pesticide residues in aquatic invertebrates. In: Edwards CA (ed) Environmental pollution by pesticides. Plenum Press, London, pp 134–180.Google Scholar
  49. Kobayashi K (1981) Proceedings of the OECD Workshop on the Control of Existing Chemicals. Umweltbundesamt, Berlin, pp 141–163.Google Scholar
  50. Konemann H (1980) Structure activity relationships and additivity in fish toxicities of environmental pollutants. Ecotoxicol Environ Safety 4:415–421.PubMedCrossRefGoogle Scholar
  51. Lech JJ, Bend JR (1980) Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish. Environ Health Perspect 34:115–131.PubMedCrossRefGoogle Scholar
  52. Lieb A J, Bills DD, Sinnhuber RO (1974) Accumulation of dietary polychlorinated biphenyls by rainbow trout. J Agric Food Chem 22:638–641.PubMedCrossRefGoogle Scholar
  53. Lu PY, Metcalf RL (1975) Environmental fate and biodegradability of benzene derivatives as studied in a model aquatic ecosystem. Environ Health Perspect 10:269–284.PubMedCrossRefGoogle Scholar
  54. Macek KJ, Rodgers CR, Stalling DL, Korn S (1970) uptake, distribution and elimination of dietary DDT and dieldrin in rainbow trout. Trans Am Fish Soc 99:689–695.CrossRefGoogle Scholar
  55. Mackay D (1979) Finding fugacity feasible. Environ Sci Technol 13:1218–1223.CrossRefGoogle Scholar
  56. Mackay D (1982) Correlation of bioconcentration factors. Environ Sci Technol 16: 274–276.CrossRefGoogle Scholar
  57. Mackay D, Patterson S (1981) Calculating fugacity. Environ Sci Technol 15:1006–1014.CrossRefGoogle Scholar
  58. Metcalfe RL, Sanborn JR, Lu P, Nye D (1975) Laboratory model ecosystem studies of the degradation and fate of radiolabeled tri-. tetra-and pentachlorobiphenyl compared with DDE. Arch Environ Contam Toxicol 3:151–165.CrossRefGoogle Scholar
  59. Metcalfe RL, Kapoor IP, Lu PY, Schuth CS, Sherman P (1973) Model ecosystem studies of the environmental fate of six organochlorine pesticides. Environ Health Perspect 35:44.Google Scholar
  60. Moriarty F (1975) Exposure and residues. In Moriarty F (ed) Organochlorine insecticides: persistent organic pollutants. Academic Press, London, pp 29–72.Google Scholar
  61. Murphy PG (1970). Effects of salinity on uptake of DDT, DDE and DDD by fish. Bull Environ Contam Toxicol 5:404–407.CrossRefGoogle Scholar
  62. Murphy PG, Murphy JV (1971) Correlations between respiration and direct uptake of DDT in the Mosquito Fish. Bull Environ Contam Toxicol 6:581–588.PubMedCrossRefGoogle Scholar
  63. Neely WB, Branson DR, Blau GE (1974) Partition coefficients to measure bio-concentration potential of organic chemicals in fish. Environ Sci Technol 8:1113–1115.CrossRefGoogle Scholar
  64. Neely BW (1979) Estimating rate constants for the uptake and clearance of chemicals by fish. Environ Sci Technol 12:1506–1510.CrossRefGoogle Scholar
  65. Norstrom RJ, McKinnon, de Freitas ASW (1976) A bioenergenics-based model for pollutant accumulation by fish. Simulation of PCB and methylmercury residue levels in Ottawa River Yellow Perch. J Fish Res Board Can 33:248–267.CrossRefGoogle Scholar
  66. OECD (1984) Data interpretation guides for initial hazard assessment of chemicals provisional. Organization for Economic Cooperation and Development, Paris.Google Scholar
  67. Ogata M, Fujisawa K, Ogino Y, Mano E (1984) Partition coefficients as a measure of bioconcentration potential of crude oil compounds in fish and shellfish. Bull Environ Contam Toxicol 33:561–567.PubMedCrossRefGoogle Scholar
  68. Oliver BG (1984) Uptake of chlorinated organics from anthropogenically contaminated sediments by oligochaete worms. Can J Fish Aquat Sci 41:878–883.CrossRefGoogle Scholar
  69. Oliver BG, Niimi AJ (1983) Bioconcentration of chlorobenzenes from water by the rainbow trout: correlations with partition coefficients and environmental residues. Environ Sci Technol 17:287–291.CrossRefGoogle Scholar
  70. Oliver BG, Niimi AJ (1985) Bioconcentration factors of some halogenated organics for rainbow trout: limitations in their use for prediction of environmental residues. Environ Sci Technol 19:842–849.CrossRefGoogle Scholar
  71. Opperhuizen A, Velde EW, Gobas FAPC, Llem DAK, Steen JMD (1985) Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals. Chemosphere 14:1871–1896.CrossRefGoogle Scholar
  72. Plant AL, Pownall H J, Smith LC (1983) Transfer of poly cyclic aromatic hydrocarbons between membranes: relation to carcinogenicity. Chem Biol Interact 44:237–246.PubMedCrossRefGoogle Scholar
  73. Reinert RE (1972) Accumulation of dieldrin in an alga, Daphnia magna and the guppy. J Fish Res Bd Can 29:1413–1418.CrossRefGoogle Scholar
  74. Roberts JR, de Freitas ASW, Gidley MAJ (1977) Influence of lipid pool size on bioaccumulation of the insecticide chlordane by northern redhorse suckers. J Fish Res Bd Can 34:89–97.CrossRefGoogle Scholar
  75. Robinson J, Richardson A, Crabtree AN, Coulson JC, Potts GR (1967) Organochlorine residues in marine organisms. Nature 214:1307–1311.PubMedCrossRefGoogle Scholar
  76. Schmidt-Bleek F, Haberland W (1980) The yardstick concept for the hazard evaluation of substances. Ecotoxicol Environ Safety 4:455–465.PubMedCrossRefGoogle Scholar
  77. Shaw GR, Connell DW (1987) Comparative kinetics for bioaccumulation of poly-chlorinated biphenyls by the polchaete (Capitella capitata) and fish (Mugil cephalus). Ecotoxicol Environ Safety 13:84–91.PubMedCrossRefGoogle Scholar
  78. Shaw GR, Connell DW (1984) Physiochemical properties controlling polychlorinated biphenyl concentrations in aquatic organisms. Environ Sci Technol 18:18–23.CrossRefGoogle Scholar
  79. Shaw GR, Connell DW (1982) Factors influencing concentrations of polychlorinated biphenyls in organisms from an estuarine ecosystem. Aust J Mar Fresh Wat Res 33:1057–1070.CrossRefGoogle Scholar
  80. Sheridan PS (1975) Uptake, metabolism and distribution of DDT on organs of the Blue Crab. Chesapeake Sci 16:20–26.CrossRefGoogle Scholar
  81. Skaar DR, Johnson BT, Jones JR, Huckins JN (1981) Fate of kepone and mirex in a model aquatic environment sediment, fish and diet. Can J Fish Aquat Sci 81:931–938.CrossRefGoogle Scholar
  82. Southward GR, Beauchamp JJ, Schnieder PK (1978) Bioaccumulation potential of polycyclic aromatic hydrocarbons in Daphnia pulex. Water Res 12:973–977.CrossRefGoogle Scholar
  83. Spacie A, Hamilink JL (1982). Alternative models for describing the bioconcentration of organics in fish. Environ Toxicol Chem 1:309–320.CrossRefGoogle Scholar
  84. Spigarelli SA, Thommes MM, Prepejchal W (1983) Thermal and metabolic factors affecting PCB uptake by adult brown trout. Environ Sci Technol 17:88–94.CrossRefGoogle Scholar
  85. Sundstrom G, Hutzinger O (1976) The metabolism of chlorobiphenyls-a review. Chemosphere 5:267–298.CrossRefGoogle Scholar
  86. Thomann RV, Connolly JP (1984) Model of PCB in the Lake Michigan trout food chain. Environ Sci Technol 18:65–71.CrossRefGoogle Scholar
  87. Veith GD, De Foe DL, Bergstedt BV (1979) Measuring and estimating the bio-concentration factor in fish. J Fish Res Bd Can 36:1040–1048.CrossRefGoogle Scholar
  88. Veith GD, Macek KJ, Petrocelli SR, Carrol J (1980) An evaluation of using partition coefficients and water solubility to estimate bioconcentration factors for organic chemicals in fish. In Eaton JG, Parrish PR, Hendricks AC (eds) Aquat Toxicol Vol 707, ASTM, Philadelphia, pp 116–123.Google Scholar
  89. Walker CH (1987) Kinetic models for predicting bioaccumulation of pollutants in ecosystems. Environ Pollut 44:227–242.PubMedCrossRefGoogle Scholar
  90. Wilkes FG, Weiss CM (1971) The accumulation of DDT by the dragonfly nymph. Trans Am Fish Soc 100:222–235.CrossRefGoogle Scholar
  91. Woodwell GM (1967) Toxic substances and ecological cycles. Sci Am 216:24–31.PubMedCrossRefGoogle Scholar
  92. Woodwell GM, Wurster CF, Isaason PA (1967) DDT residues in an east coast estuary: a case of biological concentration of a persistent insecticide. Science 156:821–824.PubMedCrossRefGoogle Scholar
  93. Zaroogian GE, Heltshe JF, Johnson M (1985) Estimation of bioconcentration in marine species using structure-activity models. Environ Toxicol Chem 4:3–12.CrossRefGoogle Scholar
  94. Zitko V (1980) Metabolism and distribution by aquatic animals. In Hutzinger O (ed) Handbook of environmental chemistry. Springer, Berlin, pp 221–229.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Des W. Connell
    • 1
  1. 1.School of Australian Environmental StudiesGriffith UniversityNathanAustralia

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