Abstract
The association of diabetes with thyroid disorders is well documented (1–9). The incidence of clinical and subclinical thyroid disorders in patients with type I diabetes (insulin-dependent diabetes or IDD) has been reported to be as high as 30% (10). The incidence of hypothyroidism in a diabetic population varies from 0.2% to 12%, with a female prevalence over males as high as 7:1 (2). Hyperthyrodism may also be increased in patients with insulin-dependent diabetes mellitus, with a ratio of females to males between 2 and 5:1 (9). If the prevalence of thyroid dysfunction is so high in women with diabetes mellitus, then the clinician who cares for pregnant women (up to 20% with thyroid problems), type I diabetic (up to 30% with thyroid problems) women (sevenfold increase in prevalence over males) should be especially aware of the strategies for diagnosis and management of thyroid disorders. This chapter briefly reviews the literature concerning thyroid disease and type I diabetes, thyroid disease and pregnancy, and the occurrence of all three together. It also suggests surveillance and treatment protocols for managing the thyroid problems that complicate pregnancies in the woman with IDD.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Irvine WJ (1979) Autoimmunity in endocrine disease. Clin Endocrinol Metab 4: 227 – 235.
Gray RS, Dorsey DQ, Seth J, et al (1980) Prevalence of subclinical thyroid failure in insulin dependent diabetes. J Clin Endocrinol Metab 50: 1034 – 1045.
Landing BH, Pettit MD, Wiens RL, et al (1964) Schmidt’s syndrome (thyroid and adrenal insufficiency). A review of the literature and report of 15 new cases including 10 instances of coexistent diabetes mellitus. Medicine 43: 153 – 162.
Ungar B, Stocks AE, Martin FIR, et al (1968) Intrinsic-factor antibody, parietalcell antibody, and latent pernicious anemia in diabetes mellitus. Lancet 1:415– 416.
Irvine WJ, Scarth L, Clarke BF, et al (1970) Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet 1: 163 – 165.
Goldstein DE, Drash A, Gibbs J, Blizzard RM (1970) Diabetes mellitus: The incidence of circulation antibodies against thyroid, gastric and adrenal tissue. J Pediatr 77: 304 – 309.
Nerup J, Binder C (1973) Thyroid, gastric and adrenal autoimmunity in diabetes mellitus. Acta Endocrinol 72: 279 – 285.
Fialkow PJ, Zavala C, Nielsen R (1975) Thyroid autoimmunity: Increase fre¬quency in relatives of insulin-dependent diabetic patients. Ann Intern Med 83: 170 – 174.
Cooppan R, Kozak GP (1980) Hyperthyroidism and diabaetes mellitus. An analysis of 70 patients. Arch Intern Med 140: 370 – 377.
Bright GM, Blizzard RM, Kaiser DI, et al (1982) Organ-specific autoantibodies in children with common endocrine diseases. J Pediatr 100: 8 – 12.
Sugrue DD, McEvoy M, Drury MI (1982) Thyroid disease in diabetics. Postgrad Med J 58: 680 – 684.
Riley WJ, MacClaren NK, Lezzote DC, et al (1981) Thyroid autoimmunity in insulin diabetes mellitus: The case for routine screening. J Pediatr 98: 350 – 356.
Jovanovic L, Subak-Sharpe G (1987) The woman’s answer book. Athenium, New York.
Jovanovic L, Singh M, Saxena BB, et al (1987) Verification of early pregnancy tests in a multicenter trial. Proc Soc Exp Biol Med 184: 201–205, 1987.
Mussey RD (1938) Changes in basal metabolic rate during pregnancy. Am J Obstet Gynecol 36: 59 – 65.
Amino N, Mari H, Iwatani Y, et al (1982) High prevalence of transient post¬partum thyroitoricosis and hypothyroidism, N Engl J Med 306: 849 – 853.
Burrow GN (1975) Pregnancy and thyroid function, Med Clin North Am. 59: 1089 – 1109.
Tulchinsky D, Ryan KJ (1980) Maternal Fetal Endocrinology, WB Saunders, Toronto, pp 115 – 128.
Silver S. (1960) The thyroid gland, medical surgical and gynecological com¬plications of pregnancy, ed 2, in Guttmacher AF, Rovinsky J J (eds). Williams & Wilkins, Baltimore, pp 561 – 582.
Mussey RD, Haines SF, Ward E (1948) Pregnancy and hyperthyroidism. Am J Obstet Gynecol 55: 609 – 615.
Sugrue D, Drury MI (1980) Hyperthyroidism complicating pregnancy: results of treatment by antithyroid drugs in 77 pregnancies. Br J Obstet Gynecol 87: 970 – 975.
Drury MI (1986) Hyperthyroidism in pregnancy. J R Soc Med 79: 317 – 319.
Jonckheer MH, Decostre P, Bastenie PA (1976) Amelioration of hyperthy¬roidism during pregnancy. Rev Gynecol Obstet 71: 205 – 210.
Serup J, Peterson S (1977) Improvement of Grave’s disease during pregnancy. Acta Obstet Gynecol Scand 56: 463 – 468.
Montoro M, Collea JV, Frasier SD, et al (1981) Successful outcome of preg¬nancy in women with hypothyroidism. Ann Intern Med 94: 31 – 39.
Soler NG, Nicholson H (1979) Diabetes and thyroid disease during pregnancy. Obstet Gynecol 54: 18 – 23.
Jovanovic L, Druzin M, Peterson CMP (1981) The effect of euglycemia on the outcome of pregnancy in insulin-dependent diabetics as compared to normal controls. Am J Med 71: 921 – 927.
Gavin LA, McMahon FA, Castle JN, et al (1978) Alterations in serum thyroid and thyroxine-binding globulin in patients with nephrosis. J Clin Endocrin Metab 1: 125 – 32.
Mogensen CE (1981) Abnormal physiological processes in the kidney in Handbook of Diabetes Mellitus. Biochemical Pathology. Brownlee M (ed). STPM Press, New York, pp 23 – 25.
Malins J (1968) Clinical Diabetes Mellitus. Ergro & Spottiswoode, London.
Burke CW, Shakespear RA (1976) Triiodthyronine and thyroxine in urine. II. Renal handling and effect of urinary protein. J Clin Endocrinol Metab 42: 504 – 510.
Mann EB (1975) Maternal hypothyroxinemia, development of 4 and 7 years old offspring, in Fisher DA, Burrows GN (eds): Perinatal thyroid physiology and disease. Raven Press, New York, pp 117 – 136.
Edis AJ (1979) Prevention and management of complications associated with thyroid and parathyroid surgery. Surg Clin North Am 59: 83 – 86.
Selenkow HA (1972) Antithyroid-thyroid therapy of thyrotoxicosis during pregnancy. Obstet Gynecol 40: 117 – 123.
Mestman JH (1981) Diagnosis and management of hyperthyroidism in preg¬nancy. Curr Probl Obstet Gynecol 4: 10 – 20.
Ramsay I, Kaur S, Krassas G (1983) Thyrotoxicosis in pregnancy: Results of treatment by antithyroid drugs combined with T4. Clin Endocrinol 18: 73 – 82.
Drury MI, Sugrue DD, Drury RM (1984) A review of thyroid disease in preg¬nancy. Clin Exp Obstet Gynecol 3: 79 – 84.
Momotani N, Jaeduk N, Hiroshi O, et al (1986) Antithyroid drug therapy for graves’ disease during pregnancy: Optimal regimen for fetal thyroid status. N Engl J Med 315: 24 – 28.
Turnstall ME (1969) The effect of propranolol on the onset of breathing at birth. Br J Anaesth 41: 792 – 795.
Bullock JL, Harris RE, Young R (1975) Propranolol as the sole treatment for Graves’ disease during pregnancy. 121: 242 – 248.
Gladstone GR, Hordof A, Gersony WM (1975) Use of propranolol during pregnancy. J Pediatr 86: 962 – 966.
Habib A, McCarthy JS (1977) Neonatal morbidity with the use of propranolol during pregnancy. J Pediatr 91: 808 – 812.
Mestman JH (1986) Polyglandular Autoimmune Syndrome and Throid Dis¬orders in Pregnancy, in Jovanovic L, Peterson CM, Fuhrmann, K (eds): Di¬abetes and Pregnancy: Teratology, Toxicology and Treatment, Praeger, New York, pp 321 – 360.
Guenter KE, Fridland GA (1956) Thyroid storm compicating pregnancy, Obstet Gynecol 26: 403 – 410.
Momotani N, Ito K. Hamada N, et al (1984) Maternal hyperthyroidism and congenital malformation in the offspring. Clin Endocrinol 20: 295 – 299.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Jovanovic, L., Peterson, C.M. (1988). Thyroid Disorders in Pregnant Women With Type I Diabetes. In: Jovanovic, L. (eds) Controversies in Diabetes and Pregnancy. Endocrinology and Metabolism, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3792-1_6
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3792-1_6
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8353-9
Online ISBN: 978-1-4612-3792-1
eBook Packages: Springer Book Archive