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Oral Hypoglycemic Agents in the Treatment of Gestational Diabetes

  • Chapter
Controversies in Diabetes and Pregnancy

Part of the book series: Endocrinology and Metabolism ((EAM,volume 2))

Abstract

The use of oral antidiabetic agents in pregnancy is a most controversial topic. Many obstetricians and diabetologists vehemently oppose their use. Their reasons, however, are usually anecdotal or based on publications about oral agents that are no longer used in pregnancy. Yet, apart from the convenience to patients, which results in greater compliance, there are other reasons that suggest their use to be logical in women with non- insulin-dependent diabetes (NIDD). Such patients do not have a lack of insulin; they frequently have an excess of insulin production but, because of “insulin resistance,” the hormone’s message is imperfectly transmitted. Thus, use of drugs that alter this situation would be more logical than adding further insulin to a system that already has enough. There is evidence (which will be discussed later) that sulfonylureas and metformin do indeed influence events concerning carbohydrate metabolism at the cellular level. However, this does not negate the importance of diet, which we believe is the cornerstone of therapy for NIDD or gestational diabetes mellitus (GDM) (1).

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Authors
  1. Edward J. Coetzee
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  2. W. P. U. Jackson
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Editor information

Editors and Affiliations

  1. Sansum Medical Research Foundation, 93105, Santa Barbara, CA, USA

    Lois Jovanovic M.D.

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Coetzee, E.J., Jackson, W.P.U. (1988). Oral Hypoglycemic Agents in the Treatment of Gestational Diabetes. In: Jovanovic, L. (eds) Controversies in Diabetes and Pregnancy. Endocrinology and Metabolism, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3792-1_4

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  • DOI: https://doi.org/10.1007/978-1-4612-3792-1_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8353-9

  • Online ISBN: 978-1-4612-3792-1

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