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Experimental Studies of Congenital Malformations in Diabetic Pregnancy

  • Chapter
Controversies in Diabetes and Pregnancy

Part of the book series: Endocrinology and Metabolism ((EAM,volume 2))

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Abstract

Despite considerable progress in the clinical management of diabetic pregnancy, the incidence of congenital malformations is approximately three times greater in infants of diabetic mothers than in the offspring of nondiabetic women (1–6). Congenital malformations observed in the infants of diabetic mothers more often tend to be multiple, more severe, and lethal than those seen in infants of nondiabetic mothers (3,5,6). The incidence of congenital malformations has not changed over the last few decades, whereas that of almost all other complications has decreased (4). The relative importance of malformations has therefore increased, and they are presently the most common cause of perinatal death among infants of diabetic mothers (5).

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  1. Ulf J. Eriksson
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  1. Sansum Medical Research Foundation, 93105, Santa Barbara, CA, USA

    Lois Jovanovic M.D.

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Eriksson, U.J. (1988). Experimental Studies of Congenital Malformations in Diabetic Pregnancy. In: Jovanovic, L. (eds) Controversies in Diabetes and Pregnancy. Endocrinology and Metabolism, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3792-1_1

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  • DOI: https://doi.org/10.1007/978-1-4612-3792-1_1

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