Abstract
Cutaneous metastases occur in up to 9% of all patients with cancer (1). They may be the first sign of visceral cancer. In a series of patients seen in dermatologic consultation with skin metastases, the underlying cancer had been undiagnosed in 60% of patients with lung cancer, 53% with renal cancer, and 40% of patients with ovarian cancer (2). Of women with cutaneous metastatic disease, the metastases were the presenting sign in 6%. The figure was even higher in men. After treatment, skin metastases may be important as the first indication of recurrence. After correlating gross and microscopic features of the primary tumor with the metastatic lesion, there may be reasons to suspect a second primary tumor (2).
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References
Spencer PS, Helm TN: Skin metastases in cancer patients. Cutis 1987; 39:119–121.
Brownstein MH, Helwig EB: Patterns of cutaneous metastasis. Arch Dermatol 1972; 105:862–868.
Brownstein MH, Helwig EB: Metastatic tumors of skin. Cancer 1972; 29:1298–1307.
Lucky AW, McGuire J, Komp DM: Infantile neuroblastoma presenting with cutaneous blanching nodules. J Am Acad Dermatol 1982; 6:389–391.
Shown TE, Durfee MF: Blueberry muffin baby: Neonatal neuroblastoma with subcutaneous metastases. J Urol 1970; 104:193–195.
Chevallier B, Asselain B, Kunlin A, et al: Inflammatory breast cancer. Determination of prognostic factors by univariate and multivariate analysis. Cancer 1987; 60:897–902.
Schwartz RA, Rubenstein DJ, Raventos A, Lambert WC: Inflammatory metastatic carcinoma of the parotid. Arch Dermatol 1984; 120:796–797.
Haupt HM, Hood AF, Cohen MH: Inflammatory melanoma. J Am Acad Dermatol 1984; 10: 52–55.
Pickard C, Callen JP, Blumenreich M: Metastatic carcinoma of the breast: An unusual presentation mimicking cutaneous vasculitis. Cancer 1987; 59:1184–1186.
Cohen I, Levy E, Schreiber H: Alopecia neoplastica due to breast carcinoma. Arch Dermatol 1961; 84:490–492.
Paget J: On disease of the mammary areola preceding cancer of the mammary gland. St. Bartholomew’s Hosp Rep 1874; 10:87–89.
Ascensao AC, Marques MSJ, Capitao-Mor M: Paget’s disease of the nipple. Dermatologica 1985; 170:170–179.
Kao GF, Graham JH, Helwig EB: Paget’s disease of the ectopic breast with an underlying intraductal carcinoma: Report of a case. J Cutan Pathol 1986; 13:59–66.
Stephenson TJ, Cotton DWK: Paget’s disease in an epidermal cyst. Dermatologica 1987; 174:186–190.
Jones RE Jr: Mammary Paget’s disease without underlying carcinoma. Am J Dermatopathol 1985; 7:361–365.
Waisman M: Carcinoma of the inframammary crease. Arch Dermatol 1978; 114:1520–1521.
Hood CI, Font RL, Zimmerman LE: Metastatic mammary carcinoma in the eyelid with histiocytoid appearance. Cancer 1973; 31:793–800.
Saida T, Iwata M: “Ectopic” extramammary Paget’s disease affecting the lower anterior aspect of the chest. J Am Acad Dermatol 1987; 17:910–913.
Brenden LD, Schwartz RA: Extramammary Paget’s disease. Am Fam Physician 1983; 28(4): 159–161.
Anthony PP, Freeman K, Warin AP: Extramammary Paget’s disease. Clin Exp Dermatol 1986; 11:387–395.
Ojeda VJ, Heenan PJ, Watson SH: Paget’s disease of the groin associated with adenocarcinoma of the urinary bladder. J Cutan Pathol 1987; 14: 227–231.
Peterson JL, McMarlin SL: Metastatic renal-cell carcinoma presenting as a cutaneous horn. J Dermatol Surg Oncol 1983; 9:815–818.
Cotton DWK, Fairris GM: Metastatic breast carcinoma of the lip: Case report. Dermatologica 1985; 171:362–365.
Grenier DJ, Kaplan RP: Occult adenocarcinoma metastatic to a skin graft donor site. J Dermatol Surg Oncol 1985; 11:1213–1216.
Smith FP, MacDonald JS, Schein PS, Ornitz RD: Cutaneous seeding of pancreatic cancer by skinny-needle aspiration biopsy. Arch Intern Med 1980; 140:855.
Hussey HH, Schwartz RA, Fleishman JS: Skin metastases from malignant neoplasms. Arch Dermatol 1982; 118:289–290.
Steck WD, Helwig EB: Tumors of the umbilicus. Cancer 1965; 18:907–915.
Powell FC, Cooper AJ, Massa MC, et al: Sister Mary Joseph’s nodule: A clinical and histologic study. J Am Acad Dermatol 1984; 10:610–615.
Goodheart RS, Cooke CT, Tan E, Matz LR: Sister Mary Joseph’s nodule. Med J Aust 1986; 145:477–478.
Cosnow I, Fretzin DF: Choriocarcinoma metastatic to skin. Arch Dermatol 1974; 109:551–553.
Avril MF, Mathieu A, Kalifa C, Caillou C: Infantile choriocarcinoma with cutaneous tumors. J Am Acad Dermatol 1986; 14:918–927.
Helson L, Garcia EJ: Skin metastases and hepatic carcinoma in childhood. NY State J Med 1975; 75:1728–1730.
Schiff BL: Tumors of testis with cutaneous metastases to scalp. Arch Dermatol 1955; 71:465–467.
Archer CB, Wells RS, MacDonald DM: Metastatic cutaneous carcinoid. J Am Acad Dermatol 1985; 13:363–366.
Cartwright LE, Steinman HK: Malignant papillary mesothelioma of the tunica vaginalis testes: cutaneous metastases showing pagetoid epidermal invasion. J Am Acad Dermatol 1987; 17:887–890.
White RM, Patterson JW: Distant skin metastases in a long-term survivor of malignant ameloblastoma. J Cutan Pathol 1986; 13:383–389.
King DT, Gurevitch AW, Hirose FM: Multiple cutaneous metastases of a scapular chondrosarcoma. Arch Dermatol 1978; 114:584–586.
Horiguchi Y, Takahashi C, Imamura S: Cutaneous metastasis from papillary carcinoma of the thyroid gland. J Am Acad Dermatol 1984; 10:988–992.
Okada N, Yamamura T, Kitano Y, et al: Metastasizing atrial myxoma: A case with multiple subcutaneous tumours. Br J Dermatol 1986; 115:239–242.
Rico MJ, Penneys NS: Metastatic follicular carcinoma of the thyroid to the skin: A case confirmed by immunohistochemistry. J Cutan Pathol 1985; 12:103–105.
Chen KTK: Scalp metastases as the initial presentation of malignant fibrous histiocytoma. J Surg Oncol 1984; 27:179–180.
Nishitani K, Nishitani H, Shimoda Y: Cutaneous invasion of mucinous adenocarcinoma of the appendix. J Dermatol (Tokyo) 1987; 14:167–169.
Schwartz RA, Fleishman JS: Transitional cell carcinoma of the urinary tract presenting with a cutaneous metastasis. Arch Dermatol 1981; 117: 513–515.
Graf L: Sacrococcygeal chordoma with metastases. Arch Pathol 1944; 37:136–139.
Fox JL, Prioleau PG: Skin metastases from small-cell carcinoma of the lung. J Dermatol Surg Oncol 1983; 9:451–454.
Ordonez NG, Samaan NA: Medullary carcinoma of the thyroid metastatic to the skin: report of two cases. J Cutan Pathol 1987; 14:251–254.
Schultz BM, Schwartz RA: Hypopharyngeal squamous cell carcinoma metastatic to skin. J Am Acad Dermatol 1985; 12:169–172.
Klein E, Schwartz RA, Solomon J, et al: Accessible tumors, in LoBuglio AF (Ed): Clinical Immunotherapy. New York, Marcel Dekker, 1980, pp 31–71.
Kahn H, Baumal R, From L: Role of immunohistochemistry in the diagnosis of undifferentiated tumors involving the skin. J Am Acad Dermatol 1986; 14:1063–1072.
Wick MR: Monoclonal antibodies in diagnostic dermatopathology. Am J Dermatopathol 1987; 9:185–189.
Lambert WC: Beyond hybridomas: cell identification by in situ nucleic acid hybridization. Am J Dermatopathol, in press.
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© 1988 Springer-Verlag New York Inc.
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Schwartz, R.A. (1988). Metastatic Cancer of the Skin. In: Skin Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3790-7_14
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DOI: https://doi.org/10.1007/978-1-4612-3790-7_14
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