Skin Cancer pp 99-140 | Cite as


  • Philip J. Cohen
  • W. Clark Lambert
  • George J. Hill
  • Robert A. Schwartz


The earliest description of melanoma is generally attributed to Hippocrates in the 5th century B.C. The disease has also been noted in several Inca mummies of comparable antiquity (1). The term melanoma was first proposed by Carswell (2) in 1838. As late as the 1950s, however, this disease was known by numerous designations, including melanosarcoma, melanocarcinoma, and nevocarcinoma (3, 4). It is now well understood that this malignancy of the pigment-producing cell arises from neural crest-derived tissue. During early gestation, melanocytes undergo migration from the neural crest to the skin and mucous membranes, uveal tract, and meninges, so that they normally appear in the epidermis, hair bulb, leptomeninges, and retina. Most melanomas occur in the skin.


Melanocytic Nevus Amelanotic Melanoma Nodular Melanoma Superficial Spreading Melanoma Vertical Growth Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Philip J. Cohen
  • W. Clark Lambert
  • George J. Hill
  • Robert A. Schwartz

There are no affiliations available

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