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Introduction to Specific Drug Action and Membrane Surface Phenomena

  • Ronald J. Tallarida
  • Robert B. Raffa
  • Paul McGonigle
Part of the Springer Series in Pharmacologic Science book series (SSPHARMACOL)

Abstract

Drugs are believed to produce their effects on biological systems either by alteration of some physical property of the cell or by a specific chemical reaction between the drug and its receptor. Many drugs produce their effects by interacting with specific cellular receptors. A description of the mathematical analysis of the interaction of drugs with receptors can be found in Chapter 8. The present chapter presents only an outline of the general development of the drug-receptor concept and highlights those aspects of the development which are considered by many the “principles” underlying present conceptions of the drug-receptor interaction. A more recent development, the recognition of cell processes (e.g., membrane capping, coated pits, and coated vesicles) capable of modifying the number of cell-surface receptors, is described in more detail.

Keywords

Coated Vesicle Extracellular Material Anesthetic Concentration Cell Surface Membrane Coated Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Robert B. Raffa
    • 1
    • 2
    • 3
  • Paul McGonigle
    • 4
  1. 1.Department of PharmacologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Janssen Research FoundationUSA
  3. 3.Jefferson Medical CollegePhiladelphiaUSA
  4. 4.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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