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Allogeneic Bone Marow Transplantation in Leukemia

  • Bruno Speck
  • Alois Gratwohl
  • André Tichelli
  • Catherine Nissen
Conference paper
Part of the Experimental Hematology Today—1987 book series (HEMATOLOGY, volume 1987)

Abstract

Erradication of leukemia by high dose chemotherapy and total body irradiation (TBI) and the capacity of hemopoietic stem cells to repopulate the marrow form the basic concept of bone marrow transplantation (BMT) in leukemia. First attempts at allogeneic BMT were made soon after the discovery of the hemopoietic stem cell. They all failed because of rejection and Graft-versus-Host disease (GvHD) (1). The recognition of the major histocompatibility complex was the basis of the first successful BMT’s in immune defiency syndromes where HLA-identical siblings served as donors (2–4). Results of BMT in leukemia, however, remained unsatisfactory because it was used almost exclusively for terminally ill patients with end-stage disease.

Keywords

Bone Marrow Transplantation Total Body Irradiation Allogeneic Bone Marrow Hemopoietic Stem Cell Bone Marrow Trans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Bruno Speck
    • 1
  • Alois Gratwohl
    • 1
  • André Tichelli
    • 1
  • Catherine Nissen
    • 1
  1. 1.Division of Hematology, Department of Internal Medicine, KantonsspitalUniversity of BaselBaselSwitzerland

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