Allogeneic Bone Marow Transplantation in Leukemia

  • Bruno Speck
  • Alois Gratwohl
  • André Tichelli
  • Catherine Nissen
Conference paper
Part of the Experimental Hematology Today—1987 book series (HEMATOLOGY, volume 1987)


Erradication of leukemia by high dose chemotherapy and total body irradiation (TBI) and the capacity of hemopoietic stem cells to repopulate the marrow form the basic concept of bone marrow transplantation (BMT) in leukemia. First attempts at allogeneic BMT were made soon after the discovery of the hemopoietic stem cell. They all failed because of rejection and Graft-versus-Host disease (GvHD) (1). The recognition of the major histocompatibility complex was the basis of the first successful BMT’s in immune defiency syndromes where HLA-identical siblings served as donors (2–4). Results of BMT in leukemia, however, remained unsatisfactory because it was used almost exclusively for terminally ill patients with end-stage disease.


Bone Marrow Transplantation Total Body Irradiation Allogeneic Bone Marrow Hemopoietic Stem Cell Bone Marrow Trans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bortin MM (1970) A compendium of the reported human bone marrow transplants. Transplantation 9: 571–580PubMedCrossRefGoogle Scholar
  2. 2.
    Gatti RA, Meuwissen HJ, Allen HD, Hong RA (1968) Immunologic reconstitution of sex-linked lymphopenic immunologic deficiency. Lancet II: 1366–1369CrossRefGoogle Scholar
  3. 3.
    Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM (1968) Bone marrow transplantation in a patient with Wiskott-Aldrich syndrome. Lancet II: 1364–1366CrossRefGoogle Scholar
  4. 4.
    De Koning J, Dooren LJ, van Bekkum DW, van Rood JJ (1969) Transplantation of bone marrow cells and foetal thymus in an infant with lymphopenic immunologic deficiency. Lancet I: 1223–1227CrossRefGoogle Scholar
  5. 5.
    Speck B (1984) Bone marrow transplantation. Acta haemat 72: 145–154PubMedCrossRefGoogle Scholar
  6. 6.
    Bortin MM (1986) Increasing utilisation. of bone marrow transplantation. Transplantation 42: 229–234PubMedCrossRefGoogle Scholar
  7. 7.
    Cornu P, Speck B, Groff P, Nissen C, Sartorius J, Burri HP, Ohnacker H (1978) Allogeneic BMT for acute leukemia. Pathol Biol 26: 49–50PubMedGoogle Scholar
  8. 8.
    Speck B, Gratwohl A, Osterwalder B, Signer E, Nissen C, Corneo M, Jeannet M (1983) Allogeneic bone marrow transplantation: The Basel trial with cyclosporine. Transplant Proc. 15: 2617–2619Google Scholar
  9. 9.
    Gratwohl A, Speck B (1986) Bone marrow transplantation with Ciclosporin. Prog. Allergy 38: 404–431Google Scholar
  10. 10.
    Häfliger B, Gratwohl A, Tichelli A, Würsch A, Speck B. High-dose Ara-C and VP16 prior to conditioning for bone marrow transplantation in patients with high-risk leukemia. Seminars in Oncology 1987 (in press)Google Scholar
  11. 11.
    Tichelli A, Walther E, Gratwohl A, Osterwalder B, Speck B (1987) Side effects of total body irradiation before bone marrow transplantation. Basel experience July 1979 to March 1986. Strahlentherapie + Onkologie 163: 245–246Google Scholar
  12. 12.
    De Witte T, Hoogenhout J, De Pauw B, Holdrinet R, Jansen J, Wessels J, van Daal W, Hustinx T, Haanen C (1986) Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft versus host disease in matched allogeneic Transplantation. Blood 67: 1302–1308PubMedGoogle Scholar
  13. 13.
    Gratwohl A, Baldomero H, Nissen C, Speck B. Engraftment of T-cell depleted rabbit bone marrow. Acta haemat. 1987 (in press)Google Scholar
  14. 14.
    Gratwohl A, Tichelli A, Würsch, Wenger R, Nissen C, De Witte T, Speck B (1987) Irradiated donor buffy coat cells for patients with T-cell depleted bone marrow. Bone Marrow Transplantation 2 (Suppl. 1): 157Google Scholar
  15. 15.
    Gratwohl A, Hermans J, Lyklema A, Zwaan FE (1987) Bone marrow transplantation for leukaemia in Europe. Report from the Leukaemia Working Party 1987. Bone Marrow Transplantation 2 (Suppl. 1): 15–18Google Scholar
  16. 16.
    Bortin MM, Gale RP (1986) Current status of allogeneic bone marrow transplantation. A report of the International Bone Marrow Transplant Registry. In: Teresaki P (ed.) Clinical Transplants, UCLA Los Angeles, pp 17–28Google Scholar
  17. 17.
    Butturini A, Bortin MM, Seeger RC, Gale RP. Graft-vs-leukemia following bone marrow transplantation: A model of immunotherapy in man (Submitted for publication)Google Scholar
  18. 18.
    Prentice HG: Oral communication at the Annual Meeting of the EBMT, March 1–4, 1987 (unpublished)Google Scholar
  19. 19.
    Gratwohl A, Zwaan FE, Hermans J, Lyklema A (1986) Bone marrow transplantation for leukemia in Europe. Bone Marrow Transplantation 1 (Suppl. 1): 177–181Google Scholar
  20. 20.
    Speck B, Bortin MM, Champlin R, Goldman JM, Herzig RH, McGlave PB, Messner HA, Weiner RS, Rimm AA (1984) Allogeneic bone marrow transplantation for chronic myelogenous leukaemia. Lancet I: 665–668CrossRefGoogle Scholar
  21. 21.
    Herzig RM, Barrett AJ, Gluckman E, Jacobsen SJ, Masaoka R, Ramsay NKC, Ringden O, Zwaan FE, Bortin MM, Blume KG, Horowitz MM, Marmont M, Prentice HG, Rimm AA, Speck B, Gale RP (1987) Bone marrow transplantation in high-risk acute lymphoblastic leukemia in first an second remission. Lancet I: 786–789CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Bruno Speck
    • 1
  • Alois Gratwohl
    • 1
  • André Tichelli
    • 1
  • Catherine Nissen
    • 1
  1. 1.Division of Hematology, Department of Internal Medicine, KantonsspitalUniversity of BaselBaselSwitzerland

Personalised recommendations