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Disillusions and Hopes About Zona Pellucida Glycoproteins

  • Shobha Sehgal
  • S. K. Gupta
Part of the Progress in Vaccinology book series (VACCINOLOGY, volume 1)

Abstract

Today there are serious concerns about the doubling time of the world’s population, which is getting progressively shorter (64). On the Indian scene, the continent has only 2.4% of world’s land area to support 14% of the population. The physical quality of life index is barely 40, which is far below the rest of the developed world (95 for the United States, 96 for Japan), and despite desperate efforts, the birth rate stands at 33 per 1,000. It is estimated that as many as 108 million couples are in the reproductive age group. There are 63,000 births against 25,000 deaths every day, and 13 million newborns added each year. The department of Science and Technology, Ministry of Health has rightly identified contraception as a thrust area. Over the last two decades several products have been floated for temporary control of fertility. These have largely been synthetic hormones but major drawbacks are that they have to be administered frequently over prolonged periods and have unacceptable side effects. It is apparent that the conventional modes of antifertility measures have been inadequate and impractical, Since vaccination has been an accepted mode for prevention of infectious diseases, it was deemed logical to devise vaccines for birth control as well. Theoretically it is possible to intercept pregnancy right from the hypothalamus to pituitary, gonads, and gametes (63). Contraceptive vaccines using β-subunit of human chorionic gonadotropins (HCG) and C-terminal peptide have already entered phase-I clinical trials (59,65). There are indications that gametes may also offer suitable modalities for birth control.

Keywords

Zona Pellucida Passive Immunization Fertility Control Ovarian Weight Immunological Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Shobha Sehgal
  • S. K. Gupta

There are no affiliations available

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