Advertisement

Potential of LH Receptor as an Immunocontraceptive Vaccine: Studies in the Baboon (Papio)

  • Brij B. Saxena
  • Mukul Singh
Part of the Progress in Vaccinology book series (VACCINOLOGY, volume 1)

Abstract

Among the new approaches, the immunological regulation of fertility has recently received considerable attention (7,14,15). Immunization against antigens present in the ovum, sperm, and placenta (1), especially the β-subunit of the chorionic gonadotropin, has demonstrated a potential of an immunocontraceptive vaccine (15). We have examined the concept of active immunization against lutenizing hormone (LH) receptor (12) on the ovarian function of female baboons (Papio), as shown in Figure 22.1. Our observations have indicated that LH receptor has a potential for the development of a contraceptive vaccine (13).

Keywords

Luteinizing Hormone Luteal Phase Chorionic Gonadotropin Menstrual Bleeding Contraceptive Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bahl OP, Muralidhar K: Current status of antifertility vaccines. Dhindsa D, Schumacher E (eds): in Immunological Aspects of Infertility and Fertility Regulation. New York, New York, Elsevier North Holland Inc., 1980, pp. 225–257.Google Scholar
  2. 2.
    Channing CP: The use of granulosa cell cultures and short-term incubations in the assay for gonadotropins. Moudgal NR (ed): in Gonadotropins and Gonadal Function. New York, Academic Press, 1974, pp. 185–188.Google Scholar
  3. 3.
    Dattatreyamurty B, Rathnam P, Saxena BB: Isolation of the luteinizing hormonechorionic gonadotropin receptor in high yield from bovine corpora lutea: molecular assembly and oligomeric nature. J Biol Chem 1982;258 (5):3140–3158.Google Scholar
  4. 4.
    Haour F, Saxena BB: Characterization and solubilization of gonadotropin receptor of bovine corpus luteum. J Biol Chem 1974;249:2195.Google Scholar
  5. 5.
    Khan FS, Rathnam P, Saxena BB: Purification and properties of human chorionic gonadotropinlutropin receptor from plasma-membrane and soluble fractions. Biochem J 1981;197:7–22.PubMedGoogle Scholar
  6. 6.
    Metsikko K, Rajaniemi H: Antibodies to purified luteinizing hormone receptor localized the receptor at the luteal surface. Endocrinology 1981; 109:1399–1403.PubMedCrossRefGoogle Scholar
  7. 7.
    Moudgal NR, Sairam MR, Mahoney J: On the immunogenicity of the β-subunit of bovine luteinizing hormone (oLH) and equine chorionic gonadotropin (eCG) in the chimpanzee (Pan troglodytes): Effect of antiserum on monkey cycle and early pregnancy. Am J Reprod Immunol 1985;8:120–124.Google Scholar
  8. 8.
    Podestà JE, Sanchez ML, Solano AR: Dynamic studies of free and occupied LH-receptor with a monoclonal anti-LH-receptor antibody. Les colloques de I’Inserm, Developements recents de l’endocrinologre du testicule. Recent progress in cellular endocrinology of the testes. INSERM 1984; pp. 277–286.Google Scholar
  9. 9.
    Rojas FJ, Asch RH: Properties of gonadotropin-stimulable adenylyl cyclase of the human corpus luetum: Regulation of hormonal responsiveness by guanyl nucleotide and magnesium ion. J Clin Endocrinol Metab 1984;59 (2):219–227.PubMedCrossRefGoogle Scholar
  10. 10.
    Saxena BB: Gonadotropin Receptors. Melvin Blecher (ed): in Methods in Receptor Research. New York, Marcel Dekker, Inc., 1976, pp. 251–299.Google Scholar
  11. 11.
    Saxena BB, Dattatreyamurty B, Ota H, et al: Subunits of luteinizing hormone human chorionic gonadotropin receptor from bovine corpora lutea. Biochemistry 1986;25:7943–7950.PubMedCrossRefGoogle Scholar
  12. 12.
    Saxena BB, Landesman R, Gupta GN, et al: New approaches in fertility regulation. J Obstet Gynecol 1984; Vol. 4 (Suppl. l):6–22.Google Scholar
  13. 13.
    Saxena BB, Singh M: Effect of active immunization with LH-receptor on the reproductive functions of female rabbits and baboons, abstract, ed, 1986. The American Fertility Society/Canadian Fertility and Andrology Society. International Congress meeting, Toronto, Canada.Google Scholar
  14. 14.
    Stevens VC: Pre-clinical safety studies on a hCG vaccine, in Gleicher N (ed): Reproductive Endocrinology. New York, Allan R Liss, 1981, p. 451.Google Scholar
  15. 15.
    Talwar GP, Singh O, Singh V, et al: Enhancement of anti gonadotropin response to the β-subunit of ovine luteinizing hormone by carrier conjugation and combination with the β-subunit of human chorionic gonadotropin, Fertil Steril 1986;46:120–126.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Brij B. Saxena
  • Mukul Singh

There are no affiliations available

Personalised recommendations