Potential of LH Receptor as an Immunocontraceptive Vaccine: Studies in the Baboon (Papio)
Among the new approaches, the immunological regulation of fertility has recently received considerable attention (7,14,15). Immunization against antigens present in the ovum, sperm, and placenta (1), especially the β-subunit of the chorionic gonadotropin, has demonstrated a potential of an immunocontraceptive vaccine (15). We have examined the concept of active immunization against lutenizing hormone (LH) receptor (12) on the ovarian function of female baboons (Papio), as shown in Figure 22.1. Our observations have indicated that LH receptor has a potential for the development of a contraceptive vaccine (13).
KeywordsCholesterol Estrogen Steam Adenosine Testosterone
Unable to display preview. Download preview PDF.
- 1.Bahl OP, Muralidhar K: Current status of antifertility vaccines. Dhindsa D, Schumacher E (eds): in Immunological Aspects of Infertility and Fertility Regulation. New York, New York, Elsevier North Holland Inc., 1980, pp. 225–257.Google Scholar
- 2.Channing CP: The use of granulosa cell cultures and short-term incubations in the assay for gonadotropins. Moudgal NR (ed): in Gonadotropins and Gonadal Function. New York, Academic Press, 1974, pp. 185–188.Google Scholar
- 3.Dattatreyamurty B, Rathnam P, Saxena BB: Isolation of the luteinizing hormonechorionic gonadotropin receptor in high yield from bovine corpora lutea: molecular assembly and oligomeric nature. J Biol Chem 1982;258 (5):3140–3158.Google Scholar
- 4.Haour F, Saxena BB: Characterization and solubilization of gonadotropin receptor of bovine corpus luteum. J Biol Chem 1974;249:2195.Google Scholar
- 7.Moudgal NR, Sairam MR, Mahoney J: On the immunogenicity of the β-subunit of bovine luteinizing hormone (oLH) and equine chorionic gonadotropin (eCG) in the chimpanzee (Pan troglodytes): Effect of antiserum on monkey cycle and early pregnancy. Am J Reprod Immunol 1985;8:120–124.Google Scholar
- 8.Podestà JE, Sanchez ML, Solano AR: Dynamic studies of free and occupied LH-receptor with a monoclonal anti-LH-receptor antibody. Les colloques de I’Inserm, Developements recents de l’endocrinologre du testicule. Recent progress in cellular endocrinology of the testes. INSERM 1984; pp. 277–286.Google Scholar
- 10.Saxena BB: Gonadotropin Receptors. Melvin Blecher (ed): in Methods in Receptor Research. New York, Marcel Dekker, Inc., 1976, pp. 251–299.Google Scholar
- 12.Saxena BB, Landesman R, Gupta GN, et al: New approaches in fertility regulation. J Obstet Gynecol 1984; Vol. 4 (Suppl. l):6–22.Google Scholar
- 13.Saxena BB, Singh M: Effect of active immunization with LH-receptor on the reproductive functions of female rabbits and baboons, abstract, ed, 1986. The American Fertility Society/Canadian Fertility and Andrology Society. International Congress meeting, Toronto, Canada.Google Scholar
- 14.Stevens VC: Pre-clinical safety studies on a hCG vaccine, in Gleicher N (ed): Reproductive Endocrinology. New York, Allan R Liss, 1981, p. 451.Google Scholar