Skip to main content

Immunobiology of Human Trophoblast

  • Chapter
  • 43 Accesses

Part of the Progress in Vaccinology book series (VACCINOLOGY,volume 1)

Abstract

The placenta is interposed between fetus and mother. It, therefore, plays a central role in the exchange of immunological information between the two. The placental cells that form the ultimate fetal-maternal interface are the trophoblasts. They comprise a heterogeneous population of cells that come into direct contact with a variety of maternal tissues at different locations throughout pregnancy (17). This is represented diagrammatically by Figure 12.1:

  1. 1.

    Enveloping each chorionic villus are two layers of trophoblasts, an inner cytotrophoblast or Langhans’layer and an outer syncytiotrophoblast.The latter can also be seen to line the surface of the intervillous blood sinusoids and to dip into the openings of some uterine veins

  2. 2.

    At the tips of some villi, cytotrophoblast cells proliferate through the overlying syncytiotrophoblast to become cytotrophoblast columns, which anchor the villi to the uterus.

Keywords

  • Human Chorionic Gonadotropin
  • Trophoblast Cell
  • Chorionic Villus
  • Extravillous Trophoblast
  • Human Trophoblast

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4612-3746-4_12
  • Chapter length: 10 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4612-3746-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   149.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brown PJ, Molloy CM, Johnson PM: Immunochemical identification of human trophoblast membrane antigens using monoclonal antibodies. J Reprod Immunol 1983;5:351–361.

    PubMed  CrossRef  CAS  Google Scholar 

  2. Butterworth BH, Loke YW: Immunocytochemical identification of cytotrophoblast from other mononuclear cell populations isolated from first-trimester human chorionic villi. J Cell Sci 1985;76:189–197.

    PubMed  CAS  Google Scholar 

  3. Butterworth BH, Khong TY, Loke YW, et al: Human cytotrophoblast populations studied by monoclonal antibodies using single and double biotin-avidin-peroxidase immunocytochemistry. J Histochem Cytochem 1985;33:977–983.

    PubMed  CrossRef  CAS  Google Scholar 

  4. Chaouat G, Kol-P: Immunoactive products of placenta. IV, Impairment by placental cells and their products of CTL function at effector stage. J Immunol 1985;135:215–222.

    PubMed  CAS  Google Scholar 

  5. Clark DA, Slapsys R, Chaput A, et al: Immu no regulatory molecules of trophoblast and decidual suppressor cell origin at the maternofetal interface. Am J Reprod Immunol Microbiol 1986;10:100–104.

    PubMed  CAS  Google Scholar 

  6. Colouscou J-M, Remacle-Bonnet MM, Pommier G, et al: Immunosuppressive properties of human placenta: study of supernatants from short-term syncytiotrophoblast cultures. J Reprod Immunol 1986;9:33–47.

    CrossRef  Google Scholar 

  7. Contractor SF: Metabolic and enzymatic activity of human trophoblast, Loke YW, Whyte A (eds): Biology of Trophoblast. Amsterdam, El sevier/North Holland Biomedical Press, 1983, pp 236–281.

    Google Scholar 

  8. Curric GA, Bagshawe KD: The masking of antigens on trophoblast and cancer cells. Lancet 1967;1:708–710.

    CrossRef  Google Scholar 

  9. Douthwaile RM, Urbach GI: In vitro antigenicity of trophoblast. AObstet Gynecol 1971;109:1023–1029.

    Google Scholar 

  10. Faulk WP. Hsi B-L: Immunobiology of human trophoblast membrane antigens, in Loke YW, Whyte A (eds): Biology of Trophoblast, Amsterdam, Elsevier/North Holland Biomedical Press, 1983, pp 535–570.

    Google Scholar 

  11. Hunt JS, King CR, Wood GW: Evaluation of human chorionic trophoblast cells and placental macrophages as stimulators of maternal lymphocyte proliferation in vitro, J Reprod Immunol 1984;6:377–391.

    PubMed  CrossRef  CAS  Google Scholar 

  12. Johnson PM, Cheng HM, Molloy CM, et al: Human trophoblast-specific surface antigens identified using monoclonal antibodies. Am J Reprod Immunol 1981; 1:246–254.

    Google Scholar 

  13. Kawata M, Parnes JR, Herzenberg LA: Transcriptional control oLA-A, B, Carnigen in human placental cytotrophoblast isolated using trophoblastand HLA-specific monoclonal antibodies and the fluorescence-activated cell sorter. J Exp Med 1984;160:633–651.

    PubMed  CrossRef  CAS  Google Scholar 

  14. Kirby DRS, Billington WD, Bradbury S, et al: Antigen barrier of the mouse placenta. Nature (London) 1964;204:548–549.

    CrossRef  CAS  Google Scholar 

  15. Kurman RJ, Main CS, Chen H-C: Intermediate trophoblast: a distinctive form of trophoblast with specific morphological, biochemical and functional features. Placenta 1984;5:349–369.

    PubMed  CrossRef  CAS  Google Scholar 

  16. Loke YW: Immunology and Immunopathotogy of the Human Foetal-Maternal Interaction. Amsterdam, Elservier/North Holland Biomedical-Press, 1978.

    Google Scholar 

  17. Loke YW, Butterworth BH: Heterogeneity of human trophoblast populations, in Gill, Wegmann (eds): Immunoregulation and Fetal Survival. New York, Oxford University Press, 1987, pp 197–209.

    Google Scholar 

  18. Loke YW, Whyte A, Davie P: Differential expression of trophoblast-specific membrane antigens by normal and abnormal human placentae and by neoplasms of trophoblastic and non-trophoblastic origin. Int J Cancer 1980;25:459–461.

    PubMed  CrossRef  CAS  Google Scholar 

  19. Loke YW, Joysey VC, Borland R: HL-A antigens on human trophoblast cells. Nature (London) 1971;232:403–405.

    CrossRef  CAS  Google Scholar 

  20. Loke YW, Butterworth BH, Margens JJ, Burland K: Identification of cytotrophoblast colonies in cultures of human placental cells using monoclonal antibodies. Placenta 1986;7:221–231.

    PubMed  CrossRef  CAS  Google Scholar 

  21. Mclntyre JA, Faulk WP: Cross-reactions between cell surface membrane antigens of human trophoblast and cancer cells. Placenta 1980; 1:197–207.

    CrossRef  Google Scholar 

  22. McIntyre JA, Faulk WP, Verhulst SJ, et al: Human trophoblast-lymphocyte crossrcactive (TLX) antigens define a new alloantigen system. Science 1983;222: U35–1137.

    Google Scholar 

  23. Macpherson TA, Ho HN, Kunz HW, et al Localization of the Pa antigen on the placenta of the rat. Transplantation 1986;41:392–394.

    PubMed  CrossRef  CAS  Google Scholar 

  24. Pross H, Mitchell H, Werkmeister J: The sensitivity of placental trophoblast cells to intra-placental and allogeneic cytotoxic lymphocytes. Am J Reprod Immunol Microbiol 1985;8:1–9.

    PubMed  CAS  Google Scholar 

  25. Redman CWG, Michael AJ, Stirrat GM, et al: Class-1 major histocompatibility complcx antigens on human extra-villous trophoblast. Immunology 1984:52:457468.

    Google Scholar 

  26. Rettig WJ, Cordon-Cardo C, Koulos JP, et al Cell surface antigens of human trophoblast and choriocarinoma defined by monoclonal antibodies. Int J Cancer 1985;35:469–475.

    PubMed  CrossRef  CAS  Google Scholar 

  27. Sunderland CA, Redman CWG, Stirrat GM: HLA A, B, C antigens are expressed on nonvillous trophoblast of the early human placenta. J Immunol 1981: 127:2614–2615.

    PubMed  CAS  Google Scholar 

  28. Thiry L, Loke YW, Whyte A, et al: Heterologous antiserum to human syncytiotrophoblast membrane is cytotoxic to retrovirus-producing cells and to some cancer cell lines . Am J Reprod Immunol 1981;1:240–245.

    Google Scholar 

  29. Travers P, Bodmer W: Preparation and characterization ofmonoclonal antibodies against placental alkaline phosphatase and other human trophoblast-associated determinants. Int J Cancer 1984;33:633–641.

    PubMed  CrossRef  CAS  Google Scholar 

  30. Truman P, Ford HC: Proteins of human placental microvilli: II. Identification and topology of the plasma membrane proteins. Placenta 1986;7:111–120.

    PubMed  CrossRef  CAS  Google Scholar 

  31. Underwood JL, Ruszkiewicz M, Barnden KL. et al: Does antigenic modulation cause the absence of major histocompatibility complex antigens on the syncytio trophoblast. Transplant Proc 1985;17:921–924.

    Google Scholar 

  32. Wells M, Hsi B-L, Faulk WP: Class I antigens of the major histocompatibility complex on cytotrophoblast of the human placenial basal plate. Am J Reprod Immunol 1984;6:167–174.

    PubMed  CrossRef  CAS  Google Scholar 

  33. Whyte A: Biochemistry of the human syncytiotrophoblast plasma membrane, in Loke YW. Whyte A (eds): Biology of Trophoblast. Amsterdam, Elsevier/North Holland Biomedical Press, 1983. pp 513–533.

    Google Scholar 

  34. Whyte A, Ragge N, Loke YW, et al: Human syncytiotrophoblast membrane proteins defined using heterologous antiserum. Clin Exp Immunol 1985;59:227

    PubMed  CAS  Google Scholar 

  35. Zuckermann F, Head JR: Susceptibility of mouse trophoblast to antibody and complement-mediated damage. Transplant Proc 1985; 17:925–927.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1988 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Loke, Y.W. (1988). Immunobiology of Human Trophoblast. In: Talwar, G.P. (eds) Contraception Research for Today and the Nineties. Progress in Vaccinology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3746-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3746-4_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8331-7

  • Online ISBN: 978-1-4612-3746-4

  • eBook Packages: Springer Book Archive