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Mice Immunized to Insulin Develop Anti-idiotypic Antibody to the Insulin Receptor

  • Yoram Shechter
  • Dana Elias
  • Rafael Bruck
  • Ruth Maron
  • Irun R. Cohen

Abstract

Several diseases of man can be related to the formation of autoantibodies that interact with surface receptors. Examples are the antibodies that trigger TSH receptor in Graves’ disease (1), antibodies that bind to and block the receptor for acetylcholine at the neuromuscular junction in myasthenia gravis (2), and antibodies that trigger insulin like responses which appear in certain (very rare) types of severe insulin-resistant diabetes (3).

Keywords

Insulin Receptor Receptor Antibody Bovine Insulin Insulin Antibody Booster Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hearn, M.T.W. 1980. Graves’ disease and the thyrotrophin receptor. Trends Biochem. Sci. 5: 75.Google Scholar
  2. 2.
    Fuehs, S. 1979. Immunology of the nicotinic acetylcholine receptor. Curr. Top. Microbiol. Immunol. 85: 1.Google Scholar
  3. 3.
    Flier, J.S., C.R. Kahn, D.B. Jarrett, and J. Roth. 1976. Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. J. Clin. Invest. 58: 1442.PubMedCrossRefGoogle Scholar
  4. 4.
    Sege, K., and P.A. Peterson. 1978. Use of anti-idiotypic antibodies as cell- surface receptor probes. Proc. Natl. Acad. Sci. USA 75: 2443.PubMedCrossRefGoogle Scholar
  5. 5.
    N.K. Jerne. 1974. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur) 125C: 373.Google Scholar
  6. 6.
    Schechter, Y., R. Maron, D. Elias, and I.R. Cohen. 1982. Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin. Science 216: 542.CrossRefGoogle Scholar
  7. 7.
    Schecter, Y., D. Elias, R. Maron, and I.R. Cohen. 1983. Mice immunized to insulin develop antibody to the insulin receptor. J. Cell. Biochem. 21: 179.CrossRefGoogle Scholar
  8. 8.
    Schecter, Y., D. Elias, R. Maron, and I.R. Cohen. 1984. Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Char-acterization of the antibodies. J. Biol. Chem. 259: 6411.Google Scholar
  9. 9.
    Elias, D., R. Maron, I.R. Cohen, and Y. Schecter. 1984. Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. II. Effects on glucose homeostasis and the insulin receptor. J. Biol. Chem. 259: 6416.PubMedGoogle Scholar
  10. 10.
    Cuatrecasas, P. 1972. Affinity chromatography and purification of the insulin receptor of liver cell membranes. Proc. Natl. Acad. Sci. USA 69: 1277.PubMedCrossRefGoogle Scholar
  11. 11.
    Cohen, I.R., and J. Talmon. 1980. H-2 genetic control of the response of T lymphocytes to insulins. Priming of nonresponder mice by forbidden variants of specific antigenic determinants. Eur. J. Immunol. 10: 284.PubMedCrossRefGoogle Scholar
  12. 12.
    Eshhar, Z., G. Strassmann, T. Waks, and E. Mozes. 1979. In vitro and in vivo induction of effector T cells mediating DTH responses to a protein and a synthetic polypeptide antigen. Cell. Immunol. 47: 378.Google Scholar
  13. 13.
    Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227: 680.CrossRefGoogle Scholar
  14. 14.
    Ouchterlony, O. 1958. Diffusion-in-gel methods for immunological analysis. Prog. Allergy 5: 1.Google Scholar
  15. 15.
    Rodbell, M. 1964. Metabolism of isolated fat ceils I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239: 375.PubMedGoogle Scholar
  16. 16.
    Cuatrecasas, P. 1971. Insulin-receptor interactions in adipose tissue cells: direct measurement and properties. Proc. Natl. Acad. Sci. USA 68: 1264.PubMedCrossRefGoogle Scholar
  17. 17.
    Moody, A.J., M.A. Stan, M. Stan, and J. Gliemann. 1974. A simple free fat cell bioassay for insulin. Horm. Metab. Res. 6: 12.Google Scholar
  18. 18.
    Kessler, S.W. 1975. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. J. Immunol. 115: 1617.PubMedGoogle Scholar
  19. 19.
    Ey, P.L., S.J. Prowse, and C.R. Jenkin. 1978. Isolation of pure IgGl, IgG2a, and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry 15: 429.PubMedCrossRefGoogle Scholar
  20. 20.
    Keck, K. 1975. Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant. Nature (London) 254: 78.CrossRefGoogle Scholar
  21. 21.
    Blundell, T., G. Dodson, D. Hodgkin, and D. Mercola. 1972. Insulin: the structure in the crystal and its reflective chemistry and biology. Adv. Protein Chem. 26: 279.CrossRefGoogle Scholar
  22. 22.
    Dayhoff, M.O. (ed.). Atlas of protein sequence and structure. D186. National Biomedical Research Foundation, Washington, D.C.Google Scholar
  23. 23.
    De Meyts, P., E. Van Obberghen, J. Roth, A. Wollmer, and D. Brandenburg. 1978. Mapping of the residues responsible for the negative cooperativity of the receptor-bin4ing region of insulin. Nature (London) 273: 504.CrossRefGoogle Scholar
  24. 24.
    Ranghino, G., J. Talmon, A. Yonath, and I.R. Cohen. 1981. Structural aspects of recognition and assembly in biological macromolecules, p. 263. In M. Bal- aban (ed.), The conformation of antigenic determinants of insulin and H-2 gene control of the immune response. International Science Services, Phila-delphia.Google Scholar
  25. 25.
    Neville, R.W., B.J. Weir, and N.R. Lazarus. 1973. Insulins of hystricomorph rodents. Diabetes 22: 851.PubMedGoogle Scholar
  26. 26.
    Roth, J., C.R. Kahn, M.A. Lesniak, P. Gorden, P. de Meyts, K. Megyesi, D.M. Neville, Jr., J.R. Gavin III, A.H. Soil, P. Freychet, I.D. Goldfine, R.S. Bar, and J.A. Archer. 1975. Receptors for insulin, NSILA-s, and growth hor¬mone: applicative to disease states in man. Recent Prog. Horm. Res. 31: 95.Google Scholar
  27. 27.
    Kono, T., and F.W. Barham. 1971. The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells. J. Biol. Chem. 246: 6210.PubMedGoogle Scholar
  28. 28.
    Kahn, C.R., K. Baird, J S. Flier, and D.B. Jarrett. 1977. Effects of auto-antibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action. J. Clin. Invest. 60: 1094.PubMedCrossRefGoogle Scholar
  29. 29.
    Elias, D., I.R. Cohen, Y. Shechter, Z. Spirer and A. Golander. 1987. Antibodies to insulin receptor followed by anti-idiotype: antibodies to insulin in child with hypoglycemia. 36: 348.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Yoram Shechter
  • Dana Elias
  • Rafael Bruck
  • Ruth Maron
  • Irun R. Cohen

There are no affiliations available

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