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Current Topics in Medical Mycology pp 170–198Cite as

Peptide Transport in Candida albicans: Implications for the Development of Antifungal Agents

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Part of the book series: Current Topics in Medical Mycology ((CT MYCOLOGY,volume 2))

Abstract

The yeast Candida albicans typically exists in a symbiotic relationship with humans (68). In the event, however, that the host is immunologically weakened upon challenge by disease or medical therapy, C. albicans can develop into a virulent pathogen. For many years this microorganism has gained increasing prominence as an opportunistic pathogen in hospital-associated infections and in compromised patients. Recently, this yeast has been documented as an agent in the morbidity and mortality of patients suffering from acquired immune deficiency syndrome (AIDS)(18).

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References

  1. Allen JG, Atherton FR, Hall MJ, Hassall CH, Holmes W, Lambert RW, Nisbet LJ, Ringrose PS: Phosphonopeptides as antibacterial agents: Alaphosphin and related phosphonopeptides. Antimicrob Agents Chemother 15:684–695, 1979.

    PubMed  CAS  Google Scholar 

  2. Ames BN, Ames GF, Young JD, Isuchiya D, Lecocq J: Illicit transport: The oligopeptide permease. Proc Natl Acad Sci USA 70:456–458, 1973.

    Article  PubMed  CAS  Google Scholar 

  3. Andrews JC, Short SA: Genetic analysis of Escherichia coll oligopeptide transport mutants. J Bacterial 161:484–492, 1985.

    CAS  Google Scholar 

  4. Atherton FR, Hall MJ, Hassall CH, Lambert RW, Lloyd WJ, Lord AV, Ringrose PS, Westmacott : Phosphonopeptides as substrates for peptide transport systems and peptidases of Escherichia coll . Antimicrob Agents Chemother 24:522–528, 1983.

    PubMed  CAS  Google Scholar 

  5. Azuma T, Saita T, Isono K: Polyoxin analogs, III. Synthesis and biological activity of aminoacyl derivatives of polyoxin C and L. Chem Pharma Bull 25:1740–1748,1977.

    CAS  Google Scholar 

  6. Barak Z, Gilvarg C: Peptide transport, Eisenberg H Katchalski-Katzir E Manson LA : Biomembranes, vol. 7. New York, Plenum Press, 1975, 167–218.

    Google Scholar 

  7. Becker JM, Covert NL, Shenbagamurthi P, Steinfeld AS, Naider F: Polyoxin D inhibits growth of zoopathogenic fungi. Antimicrob Agents Chemother 23:926–929, 1983.

    PubMed  CAS  Google Scholar 

  8. Becker JM, Naider F: Peptide transport in yeast: Uptake of radioactive trimethionine in Saccharomyces cerevisiae. Arch Biochem Biophys 278:245—255, 1977.

    Google Scholar 

  9. Becker JM, Naider F: Transport and utilization of peptides by yeast, Payne JW : Microorganisms and Nitrogen Sources. Chichester, United Kingdom, Wiley & Sons, 1980, 258–279.

    Google Scholar 

  10. Becker JM, Steinfeld A, Naider F: Novel Approach to the Development of Anticandidal Drugs. Proc Fourth International Conf Mycoses, Pan American Health Organization Scientific Publication No. 356, 1978, 303-308.

    Google Scholar 

  11. Bell G, Payne GM, Payne JW: Monitoring enzyme synthesis as a means of studying peptide transport and utilization in Escherichia coli. J Gen Microbiol 98:485–491, 1977.

    PubMed  CAS  Google Scholar 

  12. Bormann C, Huhn W, Zahner H, Rathman R, Huhn H, Konig WA: Metabolic products of microorganisms: New nikkomycins produced by mutants of Streptomyces tendae. J Antibiot 38:9–16, 1985.

    PubMed  CAS  Google Scholar 

  13. Bowers B, Levin G, Cabib E: Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae. J Bacterial 119:564–575, 1974.

    CAS  Google Scholar 

  14. Braun P, Calderone RA: Chitin synthesis in Candida albicans: Comparison of yeast and hyphal forms. J Bacterial 133:1472–1477, 1978.

    CAS  Google Scholar 

  15. Braun PC, Calderone RA: Regulation and solubilization of Candida albicans chitin synthetase. J Bacterial 14:666–670, 1979.

    Google Scholar 

  16. Cabib E, Roberts R, Bowers B: Synthesis of the yeast cell wall and its regulation. Ann Rev Biochem 51:763–793, 1982.

    Article  PubMed  CAS  Google Scholar 

  17. Cascieri T, Mallette MF: New method for study of peptide transport in bacteria. Appl Microbiol 27:457–463, 1974.

    PubMed  CAS  Google Scholar 

  18. Chandler FW: Pathology of the mycoses in patients with acquired immunodeficiency syndrome (AIDS), McGinnis MR : Current Topics in Medical Mycology, Vol. 1. New York, Springer-Verlag, 1985, 1–23.

    Google Scholar 

  19. Chattaway FW, Holmes MR, Barlow AJE: Cell wall composition of the mycelial and blastospore forms of Candida albicans. J Gen Microbiol 51:367–376, 1968.

    PubMed  CAS  Google Scholar 

  20. Chen C, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB: Internal duplication and homology wth bacterial transport proteins in the mdr 1 (P. glycoprotein) gene from multidrug-resistant human cells. Cell 47:381–389, 1986.

    Article  PubMed  CAS  Google Scholar 

  21. Chmara H, Smulkowski M, Borowski E: Growth inhibitory effects of amidotranferase inhibition in Candida albicans by epoxy-peptides. Drugs Under Exp Clin Res 6:7–14, 1980.

    CAS  Google Scholar 

  22. Chvatchko Y, Howald I, Riezman H: Two yeast mutants defective in endocytosis are defective in pheromone response. Cell 46:355–364, 1986.

    Article  PubMed  CAS  Google Scholar 

  23. Cowell JL: Energetics of glycylglycine transport in Escherichia coli. J Bacterial 120:139–146, 1974.

    CAS  Google Scholar 

  24. Davies MB: Peptide uptake in Candida albicans. J Gen Microbiol 114:181–186, 1980.

    Google Scholar 

  25. Dahn U, Hagenmaier H, Konig WA, Wolf G, Zahner H: Stoffwechselprodukte von mikroorganismen 154 Mitteilung. Nikkomycin ein neuer Hemmstoff der Chitinsynthase bei Pilzen. Arch Microbiol 197:143–160, 1976.

    Article  Google Scholar 

  26. Emmer G, Ryder NS, Grassberger MA: Synthesis of new polyoxin analogs and their activity against chitin synthetase from Candida albicans. J Med Chem 28:278–281, 1985.

    Article  PubMed  CAS  Google Scholar 

  27. Fickel TE, Gilvarg C: Transport of impermeant substances in Escherichia coli by way of oligopeptide permease. Nature (London) 241:161–163, 1973.

    CAS  Google Scholar 

  28. Fleet GH: Composition and structure of yeast cell wall in, McGinnis MR : Current Topics in Medical Mycology. New York, Springer-Verlag, 1985, 24–56..

    Google Scholar 

  29. Gilvarg C: Portage transport, Ninet L Bost PE Bouanchaud DH Florent J : The Future of Antibiotherapy and Antibiotic Research. New York, Academic Press, 1981.

    Google Scholar 

  30. Gooday GW, Gow NAR: A model of the hyphal septum of Candida albicans during germ tube formation. Exp My col 1:370–373, 1983.

    Google Scholar 

  31. Gross P, Croop J, Housman D: Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371–380, 1986.

    Article  Google Scholar 

  32. Higgins CF, Hardie MM, Jamieson D, Powell LM: Genetic map of the opp (oligopeptide permease) locus of Salmonella typhimurium. J Bacterial 153:830–836, 1983.

    CAS  Google Scholar 

  33. Higgins CF, Payne JW: Characterization of active dipeptide transport by germinating barley embryos: Effects of pH and metabolic inhibitors. Planta 136:71–76, 1977.

    Article  CAS  Google Scholar 

  34. Hilenski LL, Naider F, Becker JM: Polyoxin D inhibits colloidal gold-wheat germ agglutinin labelling of chitin in dimorphic forms of Candida albicans. J Gen Microbiol 132:1441–1451, 1986.

    PubMed  CAS  Google Scholar 

  35. Hori M, Kakiki K, Misato T: Antagonistic effect of dipeptides on the uptake of polyoxin A by Alternaria kikuchiana. J Pest Sci 2:139–149, 1977.

    Article  CAS  Google Scholar 

  36. Hori M, Kakiki K, Suzuki S, Misato T: Studies on the mode of action of polyoxins. III. Relation of polyoxin structure to chitin synthetase inhibition. Agric Biol Chem 35:1280–1291, 1971.

    Article  CAS  Google Scholar 

  37. Hruby VJ Rich DH (eds): Peptides Structure and Function: Proceedings of the Eighth American Peptide Symposium. Rockford, IL, Pierce Chemical Company, 1983.

    Google Scholar 

  38. Isono K, Azuma T, Suzuki S: Polyoxin analogs. I. Synthesis of aminoacyl derivatives of 5’-amino-5’deoxyuridine. Chem Pharmacol Bull 19:505–512, 1971.

    CAS  Google Scholar 

  39. Isono K, Nagatsu J, Kawashima Y, Suzuki S: Studies on polyoxins, antifungal antibiotics. I. Isolation and characterization of polyoxins A and B. Agric Biol Chem 29:848–854, 1965.

    Article  CAS  Google Scholar 

  40. Isono K, Nagatsu J, Kobinata K, Sasaki K, Suzuki S: Studies on polyoxins, antifungal antibiotics, V. Isolation and characterization of polyoxins C, D, E, F, G, H, and I. Agric Biol Chem 31:190–199, 1967.

    Article  CAS  Google Scholar 

  41. Jackson MB, Becker JM, Steinfeld A, Naider F: Oligopeptide transport in proline peptidase mutants of Salmonella typhimurium. J Biol Chem 251:5300–5309,1976.

    PubMed  CAS  Google Scholar 

  42. Jayakumar A, Singh M, Prasad R: Characteristics of proline transport in normal and starved cells of Candida albicans. Biochim Biophys Ada 514:348–355, 1978.

    Article  CAS  Google Scholar 

  43. Keller FA, Cabib E: Chitin and yeast budding. Properties of chitin synthetase from Saccharomyces carlsbergensis. J Biol Chem 246:160–166, 1971.

    PubMed  CAS  Google Scholar 

  44. Kenig M, Abraham EP: Antimicrobial activities and antagonists of bacilysin and anticapsin. J Gen Microbiol 94:37–45, 1976.

    PubMed  CAS  Google Scholar 

  45. Kessel D, Lubin M: On the distinction between peptidase activity and peptide transport. Biochim Biophys Acta 71:656–663, 1963.

    Article  PubMed  CAS  Google Scholar 

  46. Kingsbury WD, Boehm JC, Mehta RJ, Grappel SF: Transport of antimicrobial agents using peptide carrier systems: Anticandidal activity of mfluorophenylalanine-peptide conjugates. J Med Chem 26:1725–1729, 1983.

    Article  PubMed  CAS  Google Scholar 

  47. Kingsbury WD, Boehm JC, Mehta RJ, Grappel SF, Gilvarg C: A novel peptide delivery system involving peptidase activated prodrugs as antimicrobial agents. Synthesis and biological activity of peptidyl derivatives of 5-fluorouracil. J Med Chem 27:1447–1451, 1984.

    Article  PubMed  CAS  Google Scholar 

  48. Kingsbury WD, Boehm JC, Perry D, Gilvarg C: Portage of various compounds into bacteria by attachment to glycine residues in peptides. Proc Nat I Acad Sci ra,4 81:4573–4576, 1984.

    Article  CAS  Google Scholar 

  49. Kobinata K, Uramoto M, Nishii M, Kusakabe H, Nakamura G, Isono K: Neopolyoxins A, B, and C, new chitin synthetase inhibitors. Agric Biol Chem 44:1709–1711, 1980.

    Article  CAS  Google Scholar 

  50. Koenig WA, Loffler W, Meyer-Glauner WH, Uhman R: L-arginyl-D-allo threonyl-L-phenylalanin ein aminosaureantagonist aus dem pilz Keratinophyton terrreum. Chem Berichete 106:816–823, 1973.

    Article  CAS  Google Scholar 

  51. Lichliter WD, Naider F, Becker JM: Basis for the design of anticandidal agents from studies of peptide utilization in Candida albicans. Antimicrob Agents Chemother 10:483–490, 1976.

    PubMed  CAS  Google Scholar 

  52. Logan DA, Becker JM, Naider F: Peptide transport in Candida albicans. J Gen Microbiol 114:179–186, 1979.

    PubMed  CAS  Google Scholar 

  53. Marder R, Rose R, Becker JM, Naider F: Isolation of a peptide transportdeficient mutant of yeast. J Bacteriol 136:1174–1177, 1978.

    PubMed  CAS  Google Scholar 

  54. Matthews DM: Intestinal absorption of peptides. Physiol Rev 55:537–608, 1975.

    PubMed  CAS  Google Scholar 

  55. Matthews DM, Payne JW: Transmembrane transport of small peptides. Curr Top Membr Transp 14:331–425, 1980.

    CAS  Google Scholar 

  56. McCarthy PJ, Nisbet LJ, Boehm JC, Kingsbury WD: Multiplicity of peptide permeases in Candida albicans: Evidence from novel chromophoric peptides. J Bacterial 162:1024–1029, 1985.

    CAS  Google Scholar 

  57. McCarthy PJ, Troke PF, Gull K: Mechanism of action of nikkomycin and the peptide transport system of Candida albicans. J Gen Microbiol 131: 775–780,1985.

    PubMed  CAS  Google Scholar 

  58. Medoff G, Brajtburg J, Kobayshi GS: Antifungal agents useful in the therapy of systemic fungal infection. Annu Rev Pharmacol Toxicol 23:3030–330, 1983.

    Article  Google Scholar 

  59. Mehta RJ, Kingsbury WD, Valenta J, Actor P: Anti-Candida activity of polyoxin: Example of peptide transport in yeasts. Antimicrob Agents Chemother 25:373–374, 1984.

    PubMed  CAS  Google Scholar 

  60. Meyer-Glauner W, Bernard E, Armstrong D, Merrifield B: The antifungal activity of carrier peptides, L-arginyl-X-L-phenylalanine, containing amino acid antagonists or atypical non-biogenic Z)-amino acids in the central position. Zbl Bakt Hyg Orig A 252:274–278, 1982.

    CAS  Google Scholar 

  61. Milewski S, Chmara H, Borowski E: Growth inhibitory effect of antibiotic tetaine on yeast and mycelial forms of Candida albicans. Arch Microbiol 135:130–136, 1983.

    Article  PubMed  CAS  Google Scholar 

  62. Mitani M, Inoue Y: Antagonists of antifungal substance polyoxin. J Antibiot 21:492–496, 1968.

    PubMed  CAS  Google Scholar 

  63. Moneton P, Sarthou P, LeGoffic F: Role of the nitrogen source in peptide transport in Saccharomyces cerevisiae. FEMS Microbiol Lett 36:95–98, 1986.

    Article  CAS  Google Scholar 

  64. Moneton P, Sarthou P, LeGoffic F: Transport and hydrolysis of peptides in Saccharomyces cerevisiae. J Gen Microbiol 132:2147–2153, 1986.

    PubMed  CAS  Google Scholar 

  65. Naider F, Shenbagamurthi P, Steinfeld AS, Smith HA, Boney C, Becker JM: Synthesis and biological activity of tripeptidyl polyoxins as antifungal agents. Antimicrob Agents Chemother 24:787–796, 1983.

    PubMed  CAS  Google Scholar 

  66. Nisbet TM, Payne JW: Specificity of peptide uptake in Saccharomyces cerevisiae and isolation of a bacilysin-resistant, peptide transport deficient mutant. FEMS Microbiol Lett 7:193–196, 1979.

    Article  Google Scholar 

  67. Nisbet TM, Payne JW: Peptide uptake in Saccharomyces cerevisiae. Characteristics of a transport system shared by dipeptides and oligopeptides. J Gen Microbiol 115:127–133, 1979.

    CAS  Google Scholar 

  68. Odds FC: Candida and Candidosis. Baltimore, University Park, Press, 1979.

    Google Scholar 

  69. Payne JW: Transport and utilization of peptides by bacteria, Payne JW : Microorganisms and Nitrogen Sources. Chichester, United Kingdom, Wiley & Sons, 1980, 211–256.

    Google Scholar 

  70. Payne JW, Bell G: Direct determination of the properties of peptide transport systems in Escherichia coli using a fluorescent labelling procedure. J Bacterial 137:447–455, 1979.

    CAS  Google Scholar 

  71. Payne JW, Gilvarg C: Transport of peptides in bacteria, Rosen BP : Bacterial Transport. New York, Marcel Dekker, 1978, 325–383.

    Google Scholar 

  72. Payne JW, Nisbet TM: Limitations to the use of radioactively labeled substrates for studying peptide transport in microorganisms. FEBS Lett 119:73–76, 1980.

    Article  PubMed  CAS  Google Scholar 

  73. Payne JW, Nisbet TM: Continuous monitoring of substrate uptake by microorganisms using fluorescamine: Application to peptide transport by Saccharomyces cerevisiae and Streptococcus faecalis. J Appl Biochem 3:447–458, 1981.

    CAS  Google Scholar 

  74. Payne J, Shallow DA: Studies on drug targeting in the pathogenic fungus Candida albicans: Peptide transport mutants resistant to polyoxins, nikkomycins, and bacilysin. FEMS Microbiol Lett 28:55–60, 1985.

    Article  CAS  Google Scholar 

  75. Riezman H, Chvatchko Y, Dulic V: Endocytosis in yeast. Trends Biochem Sci 11:325–328, 1986.

    Article  CAS  Google Scholar 

  76. Sarthou P, Gonneau M, Le Goffic F: Photaffinity inhibition of peptide transport in yeast. Biochem Biophys Res Commun 110:884–889, 1983.

    Article  PubMed  CAS  Google Scholar 

  77. Shenbagamurth P, Smith HA, Becker JM, Naider F: Synthesis and biological properties of chitin synthetase inhibitors resistant to cellular peptidases. J Med Chem 29:802–808, 1986.

    Article  Google Scholar 

  78. Shenbagamurthi P, Smith HA, Becker JM, Steinfeld A, Naider F: Design of anticandidal agents: Synthesis and biological properties of analogues of polyoxin L .J Med Chem 26:1518–1522, 1983.

    Article  PubMed  CAS  Google Scholar 

  79. Smith HA, Shenbagamurthi P, Naider F, Kundu B, Becker JM: Hydrophobic polyoxins are resistant to intracellular degradation in Candida albicans. Antimicrob Agents Chemother 29:33–39, 1986.

    PubMed  CAS  Google Scholar 

  80. Steinfeld AS, Naider F, Becker JM: Synthesis and biological studies of 5-fluorocytosine conjugates as antifungal agents. J Med Chem 22:1104–1109,1979.

    Article  PubMed  CAS  Google Scholar 

  81. Sullivan PA, Yin CY, Molley C, Templeton MD, Shepherd M: An analysis of the metabolism and cell wall composition of Candida albicans during germ-tube formation. Can J Microbiol 29:1514–1525, 1983.

    Article  PubMed  CAS  Google Scholar 

  82. Ti JS, Steinfeld As, Naider F, Gulumoglu A, Lewis SV, Becker JM: Anticandidal activity of pyrimidine-peptide conjugates. J Med Chem 23:913–918, 1980.

    Article  PubMed  CAS  Google Scholar 

  83. Ugolev AM, DeLaey P: Membrane digestion, a concept of enzymic hydrolysis on cell membranes. Biochim Biophys Acta 300:105–128, 1973.

    PubMed  CAS  Google Scholar 

  84. Uramoto M, Kobinata K, Isono K, Higashijima T, Miyazawa T, Jenkins EE, McCloskey JA: Structure of neopolyoxins A, B, and C. Tetrahedron Lett 21: 3395–3399, 1980.

    Article  CAS  Google Scholar 

  85. Uramoto M, Kobinata K, Isono K, Higashijima T, Miyazawa T, Jenkins EE, McCloskey JA: Structure of neopolyoxins A, B, and C. Tetrahedron Lett 38: 1599–1603, 1982.

    CAS  Google Scholar 

  86. Wolfinbarger L, Marzluf GA: Specificity and regulation of peptide transport in Neurospora crassa. Arch Biochem Biophys 171:631–644, 1979.

    Google Scholar 

  87. Yadan JC, Gonneau M, Sarthou P, LeGoffic F: Sensitivity to Nikkomycin Z in Candida albicans: Role of peptide permeases. J Bacterial 160:884–888, 1984.

    CAS  Google Scholar 

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Authors
  1. Fred Naider
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  2. Jeffrey M. Becker
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Editors and Affiliations

  1. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27514, USA

    Michael R. McGinnis Ph.D.

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Naider, F., Becker, J.M. (1988). Peptide Transport in Candida albicans: Implications for the Development of Antifungal Agents. In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3730-3_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3730-3_5

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