Can Cytogenetic and Molecular Genetic Analyses of Malignant Human Gliomas Be Used Yet To Supplement Conventional Classification Schemes?
With the advent of improved cell culture and cytogenetic technology, particularly the introduction of chromosome banding procedures in the last 20 years, there have been a number of studies of leukemias and lymphomas which have led to the incorporation of cytogenetic findings in clinical diagnosis. The most notable of these include the 15; 17 translocation of acute promyelocytic leukemia, the 8; 14, the 2;8, and 8;22 translocations of Burkitt’s lymphoma and the 9;22 translocation of chronic granulocytic leukemia (Sandberg et al. 1984). Although there are now a number of well described and accepted cytogenetic abnormalities in solid tumors, the incorporation of them into classification schemes and their use in diagnosis and establishing prognosis is less well established than in leukemias and lymphomas. Nevertheless, several findings such as losses or deletions of chromosomes 22, 11, or 13 in meningiomas, Wilm’s tumor, and retinoblastoma respectively (Zankl and Zang 1972), and double minute chromosomes in advanced neuroblastoma (Brodeur et al. 1984) have been well established.
KeywordsEpidermal Growth Factor Receptor Acute Promyelocytic Leukemia Glioblastoma Multiforme Anaplastic Astrocytoma Cytogenetic Abnormality
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