Skip to main content
SpringerLink
Log in

Histone and Nucleosome Function in Yeast

  • Chapter
Molecular Biology of Chromosome Function

  • 123 Accesses

Abstract

The nucleosome, which contains two molecules each of histones H2A, H2B, H3, and H4, provides the basis for folding a long, negatively charged DNA polymer into a small nuclear compartment. However, the state of chromosomal condensation is reversible in response to replication, transcription, and chromosomal segregation. How the nucleosome is involved in these functions is a focus of our laboratory. Using reverse genetics we have asked which cellular functions are disturbed when histone proteins are mutated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Schlissel, M.S., and Brown, D.D. (1984) Cell 37, 903–913.

    Article  PubMed  CAS  Google Scholar 

  2. Weintraub, H. (1984) Cell 38, 17–27.

    Article  PubMed  CAS  Google Scholar 

  3. Simon, R.H., Camerini-Otero, R.D., and Felsenfeld, G. (1978) Nucleic Acids Res. 5, 4850–4858.

    Google Scholar 

  4. Jackson, V., and Chalkley, R. (1981) Cell 23, 121–134.

    Article  PubMed  CAS  Google Scholar 

  5. Smith, P.A., Jackson, V., and Chalkley, R. (1984) Biochemistry 23, 1576–1581.

    Article  PubMed  CAS  Google Scholar 

  6. McGhee, J.D., and Felsenfeld, G. (1980) Annu. Rev. Biochem. 49, 1115–1156.

    Article  PubMed  CAS  Google Scholar 

  7. Ebralidse, K.K., Grachev, S.A., and Mirzabekov, A. (1988) Nature 331, 365–367.

    Article  PubMed  CAS  Google Scholar 

  8. Allis, C.D., Chicoine, L.G., Richman, R., and Schulman, I.G. (1985) Proc. Natl. Acad. Sci. USA 82, 8048–8052.

    Article  PubMed  CAS  Google Scholar 

  9. Allfrey, V.G. (1977) In Chromatin and Chromosome Structure, 167–191, Li, H.J., and Eckhardt, R. (eds.). Academic Press, New York.

    Google Scholar 

  10. Chahal, S.S., Mathews, H.R., and Bradbury, E.M. (1980) Nature 287, 76–79.

    Article  PubMed  CAS  Google Scholar 

  11. Vavra, K.J., Allis, C.D., and Gorovsky, M.A. (1982) J. Biol. Chem. 257, 2591–2598.

    PubMed  CAS  Google Scholar 

  12. Johnston, E.M., Sterner, R., and Allfrey, V.G. (1987) J. Biol. Chem. 262, 2943–2946.

    Google Scholar 

  13. Hebbes, T.R., Thorne, A.W., and Crane-Robinson, C. (1980) EMBO J. 7, 1395–1402.

    Google Scholar 

  14. Whitlock, J.P., and Stein, A. (1978) J. Biol. Chem. 253, 3857–3861.

    PubMed  CAS  Google Scholar 

  15. Mathis, D.J., Oudet, P., Wasylyk, B., and Chambon, P. (1978) Nucleic Acids Res. 5, 3523–3547.

    Article  PubMed  CAS  Google Scholar 

  16. Wallis, J.W., Hereford, L., and Grunstein, M. (1980) Cell 22, 799–805.

    Article  PubMed  CAS  Google Scholar 

  17. Choe, J., Kolodrubetz, D., and Grunstein, M. (1982) Proc. Natl. Acad. Sci. USA 79, 1484–1487.

    Article  PubMed  CAS  Google Scholar 

  18. Hereford, L.M., Fahrner, K., Wollford, J., Rosbash, M., and Kaback, D.B. (1979) Cell 18, 1261–1271.

    Article  PubMed  CAS  Google Scholar 

  19. Smith, M., and Murray, K. (1983) J. Mol. Biol. 169, 641–661.

    Article  PubMed  CAS  Google Scholar 

  20. Smith, M., and Andresson, O.S. (1983) J. Mol. Biol. 169, 663–690.

    Article  PubMed  CAS  Google Scholar 

  21. Certa, U., Colavito-Shepanski, M., and Grunstein, M. (1984) Nucleic Acids Res. 12, 7975–7985.

    Article  PubMed  CAS  Google Scholar 

  22. Schwartz, D.C., and Cantor, C.R. (1984) Cell 37, 67–75.

    Article  PubMed  CAS  Google Scholar 

  23. Lohr, D., and Hereford, L. (1979) Proc. Natl. Acad. Sci. USA 76, 4283–4288.

    Google Scholar 

  24. Rykowski, M.C., Wallis, J.W., Choe, J., and Grunstein, M. (1981) Cell 25, 477–487.

    Article  PubMed  CAS  Google Scholar 

  25. Kolodrubetz, D., Rykowski, M.C., and Grunstein, M. (1982) Proc. Natl. Acad. Sci. USA 79, 7814–7818.

    Article  PubMed  CAS  Google Scholar 

  26. Pringle, J.R., and Hartwell, L.H. (1981) In The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, 97–142, Strathern, L.N., Jones, E.W., and Broach, J.R. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

    Google Scholar 

  27. Holm, C., Goto, T., Wang, J.C., and Botstein, S. (1985) Cell 41, 553–563.

    Article  PubMed  CAS  Google Scholar 

  28. Elliott, S.G., and McLaughlin, C.S. (1978) Proc. Natl. Acad. Sci. USA 75, 4384–4388.

    Article  PubMed  CAS  Google Scholar 

  29. Moll, R., and Wintersberger, E. (1976) Proc. Natl. Acad. Sci. USA 73, 1863–1867.

    Article  PubMed  CAS  Google Scholar 

  30. Hereford, L., Osley, M.A., Ludwig, J.R., and McLaughlin, C. (1981) Cell 24, 367–375.

    Article  PubMed  CAS  Google Scholar 

  31. Johnston, M., and Davis, R.W. (1984) Mol. Cell. Biol. 4, 1440–1448.

    PubMed  CAS  Google Scholar 

  32. Han, M., Chang, M., Kim, U.-J., and Grunstein, M. (1987) Cell 48, 589–597.

    Article  PubMed  CAS  Google Scholar 

  33. Kim, U., Han, M., Kayne, P., and Grunstein, M. (1988) EMBO J. 7, 2211–2219.

    PubMed  CAS  Google Scholar 

  34. Worcel, A., Strogatz, S., and Riley, D. (1981) Proc. Natl. Acad. Sci. USA 78, 1461–1465.

    Article  PubMed  CAS  Google Scholar 

  35. Wang, J.C. (1982) Cell 29, 724–726.

    Article  PubMed  CAS  Google Scholar 

  36. Gross, D.S., and Garrard, W.T. (1987) Trends Biochem. Sci. 12, 293–297.

    Article  CAS  Google Scholar 

  37. Fogel, S., and Welch, J.W. (1982) Proc. Natl. Acad. Sci. USA 79, 5342–5346.

    Article  PubMed  CAS  Google Scholar 

  38. Struhl, K. (1982) Cold Spring Harbor Symp. Quant. Biol. 47, 901–910.

    CAS  Google Scholar 

  39. Szent-Gyorgyi, C., Finkelstein, D.B., and Garrard, W.T. (1987) J. Mol. Biol. 193, 71–80.

    Article  PubMed  CAS  Google Scholar 

  40. Lohr, D. (1984) Nucleic Acids Res. 12, 8457–8474.

    Article  PubMed  CAS  Google Scholar 

  41. Proffitt, J.H. (1985) Mol. Cell. Biol. 5, 1522–1524.

    PubMed  CAS  Google Scholar 

  42. Oshima, Y. (1982) In The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, 159–180, Strathern, L.N., Jones, E.W., and Broach, J.R. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

    Google Scholar 

  43. Aimer, A., and Horz, W. (1986) EMBO J. 5, 2681–2687.

    Google Scholar 

  44. Aimer, A., Rudolph, H., Hinnen, A., and Horz, W. (1986) EMBO J. 5, 2689–2696.

    Google Scholar 

  45. Han, M., Kim, U.-J., Kayne, P., and Grunstein, M. (1988) EMBO J. 7, 2221–2228.

    PubMed  CAS  Google Scholar 

  46. Kyte, J., and Doolittle, R.F. (1982) J. Mol. Biol. 157, 105–132.

    Article  PubMed  CAS  Google Scholar 

  47. Pustell, J., and Kafatos, F.C. (1984) Nucleic Acids Res. 12, 643–655.

    Article  PubMed  CAS  Google Scholar 

  48. Wallis, J.W., Rykowski, M., and Grunstein, M. (1983) Cell 35, 711–719.

    Article  PubMed  CAS  Google Scholar 

  49. Schuster, T., Han, M., and Grunstein, M. (1986) Cell 45, 445–451.

    Article  PubMed  CAS  Google Scholar 

  50. Kayne, P., Han, M., Kim, U.-J., Mullins, J., Yoshizaki, F., and Grunstein, M. (1988) Cell 55, 27–39.

    Article  PubMed  CAS  Google Scholar 

  51. Nelson, D.A. (1982) J. Biol. Chem. 257, 1565–1568.

    PubMed  CAS  Google Scholar 

  52. Han, M., and Grunstein, M. (1988) Cell 55, 1137–1145.

    Article  PubMed  CAS  Google Scholar 

  53. Nakao, J., Miyanohara, A., Toh-e, A., and Matsubara, K. (1986) Mol. Cell Biol. 6, 2613–2623.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Michael Grunstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Min Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ung-Jin Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tillman Schuster
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paul Kayne
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry, University of Minnesota Medical School, Minneapolis, MN, 55455, USA

    Kenneth W. Adolph

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Grunstein, M., Han, M., Kim, UJ., Schuster, T., Kayne, P. (1989). Histone and Nucleosome Function in Yeast. In: Adolph, K.W. (eds) Molecular Biology of Chromosome Function. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3652-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3652-8_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8192-4

  • Online ISBN: 978-1-4612-3652-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation