Hormone Receptors, Tumor Differentiation, and Breast Cancer in Black Americans

  • Suresh Mohla
  • Walter M. Griffin
  • Calvin C. Sampson
  • Jerome Wilson
  • Vandana Narang
  • LaSalle D. LeffallJr


One of 11 women will develop breast cancer during her lifetime (Cancer Facts and Figures 1986). Although the disease occurs more frequently in White than in Black women, mortality rates in the two groups are comparable (Cutler and Young 1975; White and Enterline 1980) because Blacks have a poorer survival rate from breast cancer than Whites. Not only is breast cancer in Blacks detected at a relatively more advanced stage than in Whites, but it also shows a consistently lower rate of survival when calculated by disease stages (Myers and Han-key 1980; Nemoto et al. 1980). Thus, a question arises to whether biological differences (independent of socioeconomic status) may account for the survival differential within stages between Blacks and Whites.


Breast Cancer Estrogen Receptor Progesterone Receptor Tumor Grade Black Woman 
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  1. Bloom HJG, Richardson WW: Histologic grading and prognosis in breast cancer. Br J Cancer 1957;11:359–369.PubMedCrossRefGoogle Scholar
  2. Blot WJ, Fraumeni JF, Stone BJ: Geographic patterns of breast cancer in the United States. JNCI 1977;59:1407–1411.PubMedGoogle Scholar
  3. Boyd NF, Meakin JW, Hayward JL, et al: Clinical estimation of the growth rate of breast cancer. Cancer1981;48:1037–1042.PubMedCrossRefGoogle Scholar
  4. Cancer Facts and Figures: American Cancer Society, New York, 1986.Google Scholar
  5. Clark GM, Osborne CK, McGuire WL: Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer. J Clin Oncol 1984;2:1102–1109.PubMedGoogle Scholar
  6. Cole P, Cramer D: Diet and cancer of endocrine target organs. Cancer 1977;40:434–437.PubMedCrossRefGoogle Scholar
  7. Collings JR, Levin RJ, Savage N: Racial differences in oestrogen receptor and peroxide status of human breast cancer tissue. S Afr Med J 1980;57:444–446.PubMedGoogle Scholar
  8. Cutler JJ, Young JL: Third national cancer survey: Incidence data. US Department of Health, Education and Welfare Publication No. (NIH) 75–787, pp. 122, 1975.Google Scholar
  9. Fisher B, Redmond C, Brown A, et al: Treatment of primary breast cancer with chemotherapy and tamoxifen. N Engl J Med 1981;305:1–6.PubMedCrossRefGoogle Scholar
  10. Fisher B, Redmond C, Brown A, et al: Influence of tumor estrogen and progesterone levels on the response to tamoxifen and chemotherapy in primary breast cancer. J Clin Oncol 1983;1:227–241.PubMedGoogle Scholar
  11. Heuson JC, Leclercq G, Longeval E, et al: Estrogen receptor: Prognostic significance in breast cancer. In McGuire WL, Carbone PP, Vollmer EP (eds): Estrogen Receptor in Human Breast Cancer. New York: Raven Press, 1975, pp. 57–72Google Scholar
  12. Howat JMT, Harris M, Swindell R, et al: The effect of oestrogen and progesterone receptors on recurrence and survival in patients with carcinoma of the breast. Br J Cancer 1985;51:262–270CrossRefGoogle Scholar
  13. Hughes A, Jacobsen NI, Wagner RK, et al: Ovarian independent fluctuations of estradiol receptor levels in mammalian tissues. Mol Cell Endocrinol 1976;5:379–388.PubMedCrossRefGoogle Scholar
  14. Hulka BS, Chambless LE, Wilkinson WE, et al: Hormonal and personal effects on estrogen receptors in breast cancer. Am J Epidemiol 1984;119:692–704.PubMedGoogle Scholar
  15. Knight WA, Livingston RB, Gregory EJ, et al: Estrogen receptor as an independent prognostic factors for early recurrence in breast cancer. Cancer Res 1977;37:4669–4671.PubMedGoogle Scholar
  16. Lesser ML, Rosen PP, Senie RT, et al: Estrogen and progesterone receptors in breast carcinoma: Correlations with epidemiology and pathology. Cancer 1981;48:299–309.PubMedCrossRefGoogle Scholar
  17. Matsumoto K, Sugano H: Human breast cancer and hormone receptors. In Sharma RK, Criss WE (eds): Endocrine Control in Neoplasia. New York: Raven Press, 1978, pp. 191–208.Google Scholar
  18. Maynard PVR, Blarney RW, Elston CW, et al: Estrogen receptor assay in primary breast cancer and early recurrence of disease. Cancer Res 1978;38:4292–4295.PubMedGoogle Scholar
  19. McGuire WL: Hormone receptors: Their role in predicting prognosis and response to endocrine therapy. Semin Oncol 1978;5:428–433.PubMedGoogle Scholar
  20. McGuire WL, Clark GM: Role of progesterone receptors in breast cancer. Semin Oncol 1985;12:12–16.PubMedGoogle Scholar
  21. Meyer JS, Rao BR, Stevens SC, et al: Low incidence of estrogen in breast carcinomas with rapid rates of cellular replication. Cancer Res 1977;40:2290–2298.Google Scholar
  22. Mohla S, Clem-Jackson N, Hunter JB: Estrogen receptor and estrogen-induced gene expression in the rat mammary glands and uteri during pregnancy and lactation: Changes in progesterone receptors and RNA polymerase activity. J Steroid Biochem 1981a;248:6366–6374.Google Scholar
  23. Mohla S, Criss WE: The relationship of diet to cancer and hormones. In Newell GR, Ellison NM (eds): Nutrition and Cancer: Etiology and Treatment. New York: Raven Press, 1981b, pp. 93–110.Google Scholar
  24. Mohla S, Enterline JP, Sampson CC, et al: A predominance of poorly differentiated tumors among black breast cancer patients: Management and screening implications. Prog Clin Biol Res 1982a;83:249–258.Google Scholar
  25. Mohla S, Sampson CC, Khan T, et al: Estrogen and progesterone receptors in human breast cancer in black patients. Med Pediatr Oncol 1980;9:95.Google Scholar
  26. Mohla S, Sampson CC, Khan T, et al: Estrogen and progesterone receptors in breast cancer in black Americans: Correlations of receptor data with tumor differentiation. Cancer 1982b;52:552–559.CrossRefGoogle Scholar
  27. Mohla S, Sampson CC, Enterline JP, et al: Predominance of estrophilin-negative and poorly differentiated breast cancer in black patients. In Ames FC, Blumenschein GR, Montague ED (eds): Current Controversies In Breast Cancer. Austin: University of Texas Press, 1984, pp. 603–616.Google Scholar
  28. Myers MH, Hankey BF: Cancer patient survival experiences. US Department of Health, Education and Welfare Publication No. (NIH) 80–2148:1–15, 1980.Google Scholar
  29. Natarajan N, Nemoto TJ, Mettlin C, et al: Race related differences in breast cancer patients: Results of the 1982 national survey of breast cancer by the American College of Surgeons. Cancer 1985;56:1704–1709.PubMedCrossRefGoogle Scholar
  30. Nemoto TJ, Vana RN, Bedwani HW, et al: Management and survival of female breast cancer: Results of the national survey by the American College of Surgeons. Cancer 1980;45:2917–2924.PubMedCrossRefGoogle Scholar
  31. Ochi HT, Hayashi K, Nakao E, et al: Estrogen, progesterone and androgen receptors in breast cancer in the Japanese: Brief communication. JNCI 1976;60:291–293.Google Scholar
  32. Ownby HE, Frederick J, Russo J, et al: Racial differences in breast cancer patients. JNCI 1985;75:55–60.PubMedGoogle Scholar
  33. Parl FF, Wagner RK: The histopathological evaluation of human breast cancers in correlation with estrogen receptor values. Cancer 1980;47:362–367.CrossRefGoogle Scholar
  34. Pegoraro RJ, Karnan V, Nirmul D, et al: Estrogen and progesterone receptors in breast cancer among women of different racial groups. Cancer Res 1986;46:2117–2120.PubMedGoogle Scholar
  35. Rao BR, Meyers JS: Estrogen and progestin receptors in normal and cancer tissues. In McGuire WL, Raynaud JP, Baulieu EE (eds): Progesterone Receptors in Normal and Neoplastic Tissues. New York: Raven Press, 1977, pp. 155–169.Google Scholar
  36. Rich MA, Furmanski P, Brooks SC, et al: Prognostic value of estrogen receptor determinations in patients with breast cancer. Cancer Res 1978;38:4296–4298.PubMedGoogle Scholar
  37. Savage N, Levin J, DeMoor G, et al: Cytosolic oestrogen receptor content of breast cancer tissue in blacks and whites. S Afr Med J 1981;58:623–624.Google Scholar
  38. Silvestrini R: Cell kinetic and ER assays in breast cancer. Reviews on Endocrine Related Cancers 1984;18:15–19.Google Scholar
  39. Slamon DJ, Clark GM, Wong SG, et al: Human breast cancer: Correlation of relapse and survival with amplification of HER-2/neu oncogene. Science 1987;235:177–182.PubMedCrossRefGoogle Scholar
  40. Vollenweider-Zerargui L, Barrelet L, Wong Y, et al: The predictive value of estrogen and progesterone receptors’ concentration on the clinical behavior of breast cancer in women. Cancer 1986;57:1171–1180.PubMedCrossRefGoogle Scholar
  41. Vorherr H (ed): Breast Cancer; Epidemiology, Endocrinology, Biochemistry and Pathology. Baltimore: Urban and Schwarzenberg, 1980.Google Scholar
  42. Walt JA, Singhakovinta A, Brooks SC, et al: The surgical implications of estrophile protein estimations in carcinoma of the breast. Surgery 1976;80:506–512.PubMedGoogle Scholar
  43. White JE, Enterline JP: Cancer in non-white Americans. Curr Probi Cancer 1980;4:1–34.CrossRefGoogle Scholar
  44. Witliff JL: Steroid hormone receptors in breast cancer. Cancer 1984;53:630–643.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Suresh Mohla
  • Walter M. Griffin
  • Calvin C. Sampson
  • Jerome Wilson
  • Vandana Narang
  • LaSalle D. LeffallJr

There are no affiliations available

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