Metabolism and Tissue Residues

  • Shuet-Hing Lee Chiu
  • Anthony Y. H. Lu

Abstract

Ivermectin is used widely as an antiparasitic agent in food-producing animals. As in the case of any such drug, the residual tissue concentration of the therapeutic agent, or tissue residue, is a safety concern to the meat-consuming public. To evaluate the toxic potential of the residual tissue concentration of ivermectin and its metabolites, metabolism studies have been carried out in target species (cattle, sheep, swine) using the radiolabeled drug. Comparative metabolic studies were done in a laboratory animal, the rat, and in liver microsomes from various species.

Keywords

Combustion Hydrolysis Hydroxyl Manganese Ketone 

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Shuet-Hing Lee Chiu
    • 1
  • Anthony Y. H. Lu
    • 1
  1. 1.Department of Animal Drug MetabolismMerck Sharp & Dohme Research LaboratoriesRahwayUSA

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