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Biosynthesis

  • S. T. Chen
  • O. D. Hensens
  • M. D. Schulman

Abstract

The avermectins are a family of oleandrose disaccharide derivatives of pentacyclic lactones. Figure 4.1 presents a generalized structure of the avermectins produced by Streptomyces avermitilis. In addition, a number of key intermediates in the biosynthesis of the avermectins have been identified. These structures are as follows: aglycones lack the oleandrose disaccharide and possess a hydroxyl at C13; demethylavermectins lack one or more methoxyls on the oleandrose disaccharide and possess a hydroxyl at either or both the C3” and C3’; desfurano avermectins lack the oxygen at C8a and C6 and possess a CH3 at C8a and an H at C6; and 5-keto avermectins lack the hydroxyl (or methoxyl) at C5 and possess a keto group at C5.

Keywords

Propionate Carbon Avermectin Production Acetate Carbon Threonine Aldolase Average Specific Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cane DE, Liang T-C, Kaplan LK, Nallin MK, Schulman MD, Hensens OD, Douglas AW, Albers-Schonberg G (1983) Biosynthetic origin of the carbon skeleton and oxygen atoms of the avermectins. J. Am. Chem. Soc. 105:4110–4112CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • S. T. Chen
    • 1
  • O. D. Hensens
    • 1
  • M. D. Schulman
    • 1
  1. 1.Department of Fermentation MicrobiologyMerck Sharp & Dohme Research LaboratoriesRahwayUSA

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