Abstract
Digoxin is a commonly used inotropic agent for the treatment of congestive heart failure. Approximately 87% of the drug is excreted unchanged by the kidneys. When the kidney glomerular filtration rate is normal, the serum half-life is about 36 hours, and with a decreased glomerular filtration rate the serum half-life is prolonged. Because digoxin toxicity can produce serious cardiac rhythm disturbances as well as other problems, special care must be taken in giving digoxin to patients with impaired renal function. Here we consider a digoxin dosing protocol based on renal creatinine clearance.
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Reference
Seeman P, Sellers EM, Roschlau WHE: Principles of Medical Pharmacology, ed, 3. Toronto, University of Toronto Press, 1980, p 636.
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© 1989 Springer-Verlag New York Inc.
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Doyle, D.J. (1989). Digoxin Dosing Algorithm (DIG). In: Computer Programs in Clinical and Laboratory Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3576-7_3
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DOI: https://doi.org/10.1007/978-1-4612-3576-7_3
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8162-7
Online ISBN: 978-1-4612-3576-7
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