Digoxin Dosing Algorithm (DIG)

  • D. John Doyle


Digoxin is a commonly used inotropic agent for the treatment of congestive heart failure. Approximately 87% of the drug is excreted unchanged by the kidneys. When the kidney glomerular filtration rate is normal, the serum half-life is about 36 hours, and with a decreased glomerular filtration rate the serum half-life is prolonged. Because digoxin toxicity can produce serious cardiac rhythm disturbances as well as other problems, special care must be taken in giving digoxin to patients with impaired renal function. Here we consider a digoxin dosing protocol based on renal creatinine clearance.


Creatinine Clearance Maintenance Dose Inotropic Agent Dose Protocol Digoxin Toxicity 
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  1. 1.
    Seeman P, Sellers EM, Roschlau WHE: Principles of Medical Pharmacology, ed, 3. Toronto, University of Toronto Press, 1980, p 636.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • D. John Doyle
    • 1
  1. 1.Institute of Biomedical Engineering and Department of AnaesthesiaUniversity of TorontoTorontoCanada

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