Antigen Society #30 Report (DRw53)
The HLA-DRw53 specificity, previously known as WiA4x7 and MT3, was originally considered to be expressed on DR4, DR7, DRw9, and possibly DRw10 cells (1). Based on prior biochemical studies of the class II molecules, the ideal concept of the DRw53 specificity is that it would be only expressed on the DR molecule containing the DRB4 chain encoded by, for example, DR4, 7, and w9 haplotypes (2,3). However, the serologic reality has thus far proven to be somewhat more complex than this ideal goal, as demonstrated by the results of this antigen society analysis.
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- 1.Nakata S, Park MS, Omori K. MT3. Joint report. In: Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Press, Los Angeles 1980; p 569.Google Scholar
- 2.Nuñez-Roldan A, Gregersen PK, Winchester RJ, Silver J. Analysis of class II genes from a DR5, DQw1 haplotype: implications for haplotype evolution. ASHI, 1986.Google Scholar
- 3.Merryman P, Gregersen PK, Lee S, Silver J, Nuñez-Roldan A, Crapper R. Nucleotide sequence of DRw10 β chain gene; identity of the third diversity region with that of the DRw53 allele of the β2 locus and as the probable site encoding a polymorphic MHC class II epitope. J Immunol 1988; 140: 2447.PubMedGoogle Scholar