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RFLP: Sequence Interrelations at the DPA and DPB Loci

  • Malcolm J. Simons
  • Henry A. Erlich
Conference paper

Abstract

In the RFLP summary report (1), the RFLP reactivity patterns of 68 Workshop cells were reported. At the DPB1 locus, fragment patterns enabled current DPw1–5 specificities to be distinguished. None of the studied Workshop cells were assigned the DPw6 specificity. In addition, RFLP patterns indicative of subtypes of DPw2 and DPw4 specificities were identified, along with patterns associated with DPw “blank” cells representing new specificities.

Keywords

Fragment Pattern RFLP Pattern Cell Relationship International Histocompatibility Workshop RFLP Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Simons MJ, Wheeler R, Cohen D, Lalouel J-M, Dupont B. Restriction fragment length polymorphism of HLA genes: Summary of the Tenth International Workshop Southern Blot Analysis. In: Dupont B (ed). Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.Google Scholar
  2. 2.
    Hyldig-Nielsen J-J, Svejgaard A. Workshop report for the HLA-DP region. In: Dupont B (ed). Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.Google Scholar
  3. 3.
    Bugawan TL, Horn GT, Long CM, et al. Analysis of HLA- DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP alpha and DP beta loci. J Immunol 1988; 141:4024.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York 1989

Authors and Affiliations

  • Malcolm J. Simons
  • Henry A. Erlich

There are no affiliations available

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