Serologic Exercises of the Tenth Workshop

Abstract

The serologic exercises of the Tenth International Histocompatibility Workshop were conducted with the following goals:

• 1. To produce a central or “core” serology set of excellent reagents for the purpose of phenotyping the families and homozygous cell lines used in the Workshop.

• 2. To provide serologic analysis on a large set of class I and class II monoclonal antibodies.

• 3. To study the utility of a noncytotoxic serology technique (ELISA assay) for the definition of HLA specificities with mouse monoclonal antibodies, and to compare the results with cytotoxicity.

• 4. To permit intensive study of a large number of sera, in addition to the core set, which exhibit reactivity with a related set of antigens by establishing “Antigen Societies” or groups of laboratories with a particular interest in that set of antigens.

• 5. To develop, in collaboration with the Howard Hughes Medical Institute, Salt Lake City, Utah, permanent software resources that would permit the collection, merging, sharing, and flexible analysis of serologic and phenotypic data in individual laboratories and groups of labs.

¹NCYCAR, ²US5TER, ³US7LAL, ⁴UKIBOD, ⁵NCYYUN