Abstract
Within the DR5 cluster several distinct subtypes have been identified. The classic Dw5 specificity encompasses a heterogeneous group of cells, including many of the DR5 cell lines represented in the Workshop cell panel. Additional DR5 specificities that can be serologi cally recognized include the DB2 group (associated with DQw1 rather than DQw3) and the DB6 group (associated with DRw12 rather than DRw11). Two Workshop cell lines, 9039(JVM) and 9042(TISI), represent distinct DR5-associated specificities. These cells can be distin guished from Dw5 in cellular studies, although they cannot presently be serologically distinguished from other DRw11 haplotypes. Evidence for additional cellularly defined polymorphism within DR5 exists as well.
Participating Laboratory: US7HAN,1 FRAOHA,2 US2BAC,3 FRALEV,4 FRAMYE,5 USIDUQ,6 US7NFL,7
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References
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Mickelson, E. et al. (1989). DR5: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop. In: Dupont, B. (eds) Immunobiology of HLA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3552-1_107
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DOI: https://doi.org/10.1007/978-1-4612-3552-1_107
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