Nervous System Regeneration and Repair Following Injury
Injuries and disease that result in neuronal loss or degeneration represent a substantial health problem. Spinal cord injuries leading to paraplegia or quadraplegia affect about 100,000 people, head injuries about 3 million, stroke about 2 million, and degenerative diseases of various sorts (Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease) affect millions more. Thus, problems that lead to the degeneration of CNS neurons are quite common.
KeywordsCaudate Nucleus Superior Colliculus Lateral Geniculate Nucleus Postsynaptic Cell Normal Target
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Orthograde and Retrograde Degeneration
- Cowan WM (1970) Anterograde and retrograde transneuronal degeneration in the central and peripheral nervous system, in Ebbesson SOE, Nauta WJH (eds): Contemporary Research Methods in Neuroanatomy. New York, Springer-Verlag, pp 217–251Google Scholar
- Powell TPS, Erulkar SD (1962) Transneuronal cell degeneration in the auditory relay nuclei of the cat. J Anat 91:249–268Google Scholar
- Tower SS (1939) The reaction of muscle to denervation. Physiol Rev 19:1–48Google Scholar
- Cannon WB Denervation Supersensitivity. London, Macmillan.Google Scholar
Role of Schwann Cells in Axon Regeneration
- Aguayo A, David S, Richardson P et al. (1982a) Axonal elongation in peripheral and central nervous system transplants. Adv Cell Neurobiol 3:215–234Google Scholar
- Aguayo AJ, Richardson PM, Benfey M (1982b) Transplantation of neurons and sheath cells-a tool for the study of regeneration, in Nicholls JG (ed): Repair and Regeneration of the Nervous System, Life Sciences Research Report 24. Berlin, Springer-Verlag, pp 91–106Google Scholar
Astrocytes and Phagocytosis of Degeneration Debris
- Cotman CW, Nadler JV (1981) Reactive synaptogenesis in the hippocampus, in Cotman CW (ed): Neuronal Plasticity. New York, Raven Press, pp 227–271Google Scholar