Laser Angioplasty of the Coronary Arteries

  • Garrett Lee
  • Reginald I. Low
  • Agustin J. Argenal
  • Rolf G. Sommerhaug
  • Ming C. Chan
  • Dean T. Mason


Since the laser was shown to be effective in removing coronary atherosclerotic obstruction in postmortem hearts,1 much enthusiasm has been generated to rapidly apply this new technology to the clinical setting. It is hoped that the laser, once fully developed, will re-canalize obstructed coronary arteries without the necessity of open-chest bypass graft surgery, thus avoiding the expense and the lengthy hospital recovery of the surgical procedure in those afflicted with the disease. Recognizing that any new technology requires research effort and time to develop, the purpose of this report is to review the current status of laser revascularization of the coronary arteries.


Atherosclerotic Plaque Laser Energy Balloon Angioplasty Argon Laser Saphenous Vein Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lee G, Ikeda RM, Kozina J, et al: Laser dissolution of coronary atherosclerotic obstruction. Am Heart J 1981; 102:1074–1075.PubMedCrossRefGoogle Scholar
  2. 2.
    Abela GS, Normann S, Cohen D, et al: Effects of carbon dioxide, Nd-YAG and argon laser radiation on coronary atheromatous plaques. Am J Cardiol 1982; 50:1199–1205.PubMedCrossRefGoogle Scholar
  3. 3.
    Choy DSJ, Stertzer S, Rotterdam HZ, et al: Laser coronary angioplasty: Experience with 9 cadaver hearts. Am J Cardiol 1982; 50:1209–1211.PubMedCrossRefGoogle Scholar
  4. 4.
    Lee G, Ikeda R, Herman I, et al: The qualitative effects of laser irradiation on human arteriosclerotic disease. Am Heart J 1983; 105:885–889.PubMedCrossRefGoogle Scholar
  5. 5.
    Linsker R, Srinivasan R, Wynne JJ, et al: Far-ultraviolet laser ablation of atherosclerotic lesions. Lasers Surg Med 1984; 4:201–206.PubMedCrossRefGoogle Scholar
  6. 6.
    Grundfest W, Litvack F, Forrester J, et al: Pulsed ultraviolet lasers provide precise control of atheroma ablation. Circulation 1984; 70(suppl II):35.Google Scholar
  7. 7.
    Isner JM, Clarke RH, Donaldson RF, et al: The excimer laser: Gross, light microscopic, and ultrastructural analysis of potential advantages for use in laser therapy of cardiovascular disease. Circulation 1984; 70(suppl II):35.Google Scholar
  8. 8.
    Deckelbaum LE, Isner JM, Donaldson RT, et al: Use of pulsed energy delivery to minimize tissue injury resulting from carbon dioxide laser irradiation of cardiovascular tissues. J Am Coll Cardiol 1986; 7:898–908.PubMedCrossRefGoogle Scholar
  9. 9.
    Eldar M, Battler A, Neufeld HN, et al: Transluminal carbon dioxide laser catheter angioplasty for dissolution of atherosclerotic plaques. J Am Coll Cardiol 1984; 3:135–137.PubMedCrossRefGoogle Scholar
  10. 10.
    Lee G, Ikeda RM, Chan MC, et al: Dissolution of human atherosclerotic disease by fiberoptic laser-heated metal cautery cap. Am Heart J 1984; 107:777–778.PubMedCrossRefGoogle Scholar
  11. 11.
    Lee G, Chan MC, Rink DL, et al: Coronary revascularization by a new coaxially guided laser-heated metal cap system. Am Heart J 1987; 113:1507–1508.PubMedCrossRefGoogle Scholar
  12. 12.
    Isner JM, Clarke RH, Donaldson RF, et al: Identification of photoproducts liberated by in vitro laser irradiation of atherosclerotic plaque, calcified cardiac valves and myocardium. Am J Cardiol 1985; 55:1192–1196.PubMedCrossRefGoogle Scholar
  13. 13.
    Kaminow IP, Wiesenfeld JM, Choy DSJ: Argon laser disintegration of thrombus and atherosclerotic plaque. Appl Optics 1984; 23:1301–1302.CrossRefGoogle Scholar
  14. 14.
    Gerrity RG, Loop FD, Golding LAR, et al: Arterial response to laser operation for removal of atherosclerotic plaques. J Thorac Cardiovasc Surg 1983; 85:409–421.PubMedGoogle Scholar
  15. 15.
    Abela G, Franzini D, Crea F, et al: No evidence of accelerated atherosclerosis following laser radiation (abstr). Circulation 1984; 70(suppl II):323.Google Scholar
  16. 16.
    Lee G, Chan MC, Ikeda RM, et al: Intravascular steerable guidewire for fiberoptic laser-heated metal cautery cap in dissolution of human atherosclerotic coronary disease. Am Heart J 1985; 110:1304–1306.PubMedCrossRefGoogle Scholar
  17. 17.
    Lee G, Seckinger D, Chan MC, et al: Potential complications of coronary laser angioplasty. Am Heart J 1984; 106:1577–1579.CrossRefGoogle Scholar
  18. 18.
    Lee G, Ikeda RM, Theis JH, et al: Acute and chronic complications of laser angioplasty. Vascular wall damage and formation of aneurysms in the atherosclerotic rabbit. Am J Cardiol 1984; 53:290–293.PubMedCrossRefGoogle Scholar
  19. 19.
    Lee G, Ikeda RM, Chan MC, et al: Limitations, risks and complications of laser recanalization: A cautious approach warranted. Am J Cardiol 1985;56:181–185.PubMedCrossRefGoogle Scholar
  20. 20.
    Choy DSJ, Stertzer SH, Myler RK, et al: Human coronary laser recanalization. Clin Cardiol 1984;7:377–381.PubMedGoogle Scholar
  21. 21.
    Choy DSJ, Marco J, Fournial G, et al: Argon laser recanalization of three totally occluded human right coronary arteries. Clin Cardiol 1986; 9:296–298.PubMedCrossRefGoogle Scholar
  22. 22.
    Livesay JJ, Leachman DR, Hogan PJ, et al: Preliminary report on laser coronary endar-terectomy in patients. Circulation 1985; 72(suppl III):302.Google Scholar
  23. 23.
    Lee G, Reis RL, Chan MC, et al: Clinical laser recanalization of coronary obstruction. Angio-scopic and angiographic documentation. Chest 1986; 90:770–772.PubMedCrossRefGoogle Scholar
  24. 24.
    Lee G, Garcia J, Chan MC, et al: Clinically successful long-term laser coronary recanalization. Am Heart J 1986; 112:1323–325.PubMedCrossRefGoogle Scholar
  25. 25.
    Lee G, Chan MC, Ikeda RM, et al: Applicability of laser to assist coronary balloon angioplasty. Am Heart J 1985; 110:1233–1236.PubMedCrossRefGoogle Scholar
  26. 26.
    Sanborn TA, Faxon DP, Kellett MA, et al: Percutaneous coronary laser thermal angioplasty with a metallic capped fiber. J Am Coll Cardiol 1987;9:104A.Google Scholar
  27. 27.
    Sanborn TA, Faxon DP, Kellett MA, et al: Percutaneous coronary laser thermal angioplasty. J Am Coll Cardiol 1986; 8:1437–1440.PubMedCrossRefGoogle Scholar
  28. 28.
    Spears JR, Serur J, Shropshire D, et al: Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative. J Clin Invest 1983; 71:395–399.PubMedCrossRefGoogle Scholar
  29. 29.
    Hundley RF, Spears JR, Weinstein R: Photodynamic cytolysis of arterial smooth muscle cells in vitro: Implication for laser angioplasty. J Am Coll Cardiol 1985; 5:408.Google Scholar
  30. 30.
    Chan MC, Lee G, Seckinger DL, et al: Pre-treatment with vital dyes to enhance or attenuate argon laser energy absorption in blood vessels. Circulation 1984; 70(suppl II):298.Google Scholar
  31. 31.
    Lee G, Ikeda RM, Stobbe D, et al: Laser irradiation of human atherosclerotic obstructive disease: Simultaneous visualization and vaporization achieved by a dual fiberoptic catheter. Am Heart J 1983; 105:163–164.PubMedCrossRefGoogle Scholar
  32. 32.
    Lee G, Ikeda RM, Stobbe D, et al: Intraoperative use of dual fiberoptic catheter for simultaneous in vivo visualization and laser vaporization of peripheral atherosclerotic obstructive disease. Cathet Cardiovasc Diagn 1984; 10:11–16.PubMedCrossRefGoogle Scholar
  33. 33.
    Lee G, Garcia JM, Corso PJ, et al: Correlation of coronary angioscopy to angiographic findings in patients with coronary artery disease. Am J Cardiol 1986; 58:238–241.PubMedCrossRefGoogle Scholar
  34. 34.
    Spears JR, Spokojny AM, Marais J: Coronary angioscopy during cardiac catheterization. J Am Coll Cardiol 1985; 6:93–97.PubMedCrossRefGoogle Scholar
  35. 35.
    Bommer WJ, Lee G, Rebeck K, et al: Two-dimensional echocardiography of argon-laser vapor trails: Monitoring of catheter position and prevention of potential complications (ab-str). Circulation 1983; 68:259.Google Scholar
  36. 36.
    Bommer WJ, Chan MC, Lee G, et al: Laser doppler angioplasty: A new technique. Clin Res 1987;35:100A.Google Scholar
  37. 37.
    Kittrell C, Willett RL, de los Santos-Pacheo C, et al: Diagnosis of fibrous arterial atherosclerosis using fluorescence. Appl Optics 1985; 24:2280–2281.CrossRefGoogle Scholar
  38. 38.
    Sartori M, Henry PD, Roberts R, et al: Estimation of arterial wall thickness and detection of atherosclerosis by laser induced argon fluorescence. J Am Coll Cardiol 1986; 7:207A.Google Scholar

Copyright information

© Spring-Verlag New York Inc. 1989

Authors and Affiliations

  • Garrett Lee
  • Reginald I. Low
  • Agustin J. Argenal
  • Rolf G. Sommerhaug
  • Ming C. Chan
  • Dean T. Mason

There are no affiliations available

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