Luteinizing Hormone and Prolactin Response to Buprenorphine in Depression and Schizophrenia

  • C. Schmauss
  • K. M. Pirke
  • D. E. Bremer
  • M. M. Weber
  • H. M. Emrich
Chapter

Abstract

An association of hyper- or hypoactivity of endogenous opioids with depressive and schizophrenic psychoses has, to date, not been convincingly demonstrated. Such an assumption could, however, imply an altered sensitivity of structures involved in the mediation of opioid effects. The effects of opioids on pituitary prolactin (PRL)1,2 and luteinizing hormone (LH) release3,4 in man are well described, and there is little doubt that these effects are mediated through distinct opioid receptor populations. We have demonstrated that the partial opioid agonist buprenorphine exerts both antidepressive and antischizophrenic effects.5 We report here on LH and PRL responses of depressed and schizophrenic patients to acute buprenorphine medication in comparison to respective responses of healthy volunteers.

Keywords

Placebo Catheter Depression Cortisol Schizophrenia 

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • C. Schmauss
  • K. M. Pirke
  • D. E. Bremer
  • M. M. Weber
  • H. M. Emrich

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