Abstract
In the rat the integrity of the olfactory system is necessary for the normal functioning of the limbic system; disruption of the olfactory system results in behavioral abnormalities that are unrelated to a deficit in olfaction.1 There is evidence that lesions of the olfactory bulbs result in degeneration of limbic and nonlimbic regions that receive afferent projections from the bulbs. Such changes could be responsible for the specific behavioral effects as a consequence of the changes in the response of the animal to external and internal stimuli. Changes in social behaviors (e.g., increased aggression, territorial activity, and increased irritability), sexual behavior (e.g., maternal and mating behaviors), and such nonsocial behaviors as exploratory activity and passive avoidance learning have been reported to occur in rats following bulbectomy. These behavioral deficits have been reviewed by Leonard and Tuite.2 Of the nonsocial behaviors that are disrupted following bulbectomy, active avoidance performance is largely facilitated, whereas passive avoidance shows behavioral deficits.3,4 Anosmia, caused by the irrigation of the olfactory mucosa with zinc sulfate solution, does not cause any of the behavioral deficits reported to occur following bilateral bulbectomy.5
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© 1989 Springer-Verlag New York Inc.
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Leonard, B.E., Butler, J., O’Neill, B., O’Connor, W.T. (1989). Bilaterally Olfactory Bulbectomized Rat Model of Depression. In: Lerer, B., Gershon, S. (eds) New Directions in Affective Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3524-8_3
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DOI: https://doi.org/10.1007/978-1-4612-3524-8_3
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-96769-1
Online ISBN: 978-1-4612-3524-8
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