Light-Dark-Related Changes in the Serotonin Uptake Molecular Complex in Rat Brain: Involvement in Antidepressant Action
Clinical studies have clearly indicated that acute episodes and relapses of major depressive illness are characterized by a rhythmic cycle during the year, their incidence being highest during the spring and autumn.1 In addition, circadian modifications in the mood of depressed patients and in the efficacy of antidepressive therapies have been observed2–4 together with disruption or desynchronization of hormonal circadian patterns.5 Based on the above observations, it has been postulated that in those depressed patients susceptible to seasonal bouts of the illness, a circadian and/or seasonal desynchronization occurs and may be corrected by antidepressant drugs1,6 or light therapy.4
KeywordsCerebral Cortex Circadian Rhythm Depressed Patient Antidepressant Drug Serotonin Uptake
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