Study of Olfactory Bulbectomized Rats: Revelations About Major Depressive Disorder

  • J. Steven Richardson


The idea of using rats to learn about human psychiatric conditions such as major depressive disorder raises many questions and poses several conceptual difficulties. However, on the neuroanatomical and neurochemical levels, the rat brain and the human brain are roughly congruent, and all available evidence indicates that antidepressant drugs act on brain tissue from both species in similar ways. The main problem appears to be that whereas most interaction with major depressive disorder patients is on the verbal level the investigator must interact with the rat in a nonverbal manner.


Major Depressive Disorder Antidepressant Drug Major Depressive Disorder Patient Depressed Person Olfactory Bulbectomy 
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© Springer-Verlag New York Inc. 1989

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  • J. Steven Richardson

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