Patient Characteristics and Factors Associated with Chronic Depression and Its Treatment
Depression in most patients remits spontaneously or responds to antidepressant treatment. The few patients in whom it does not form a group who pose a significant therapeutic challenge. Robins and Guze1 reviewed 20 follow-up studies of affective disorders and concluded that a chronic course supervened in 1–28% of cases (average 12–15%). This wide variation depends on nonuniformity of diagnostic criteria for depression, assessment methods employed, and in particular the intensity of follow-up. In this study the definition used was that of Cassano et al.2: “Chronicity refers to symptomatic nonrecovery for a period of 2 or more years and may be a sequel to one or more episodes of depression from which the patient does not recover.”
KeywordsDepression Lithium Vanadium Neurol Washout
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