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Neuropeptides and Affective Disorders

  • Jan M. Van Ree
  • David De Wied
Chapter

Abstract

Pituitary hormones regulate the endocrine organs, are involved in many homeostatic mechanisms in the body, and have direct effects on processes in the central nervous system. The latter was initially demonstrated by animal behavioral experiments1 and confirmed by neurochemical and electrophysiological studies in animals.2 Fragments of pituitary hormones may have similar effects on behavior as the parent hormones, but interestingly they hardly elicit the classical endocrine actions of the parent hormones. The central effects of pituitary hormones and their fragments indicate that they belong to the category of neuropeptides, which are peptide molecules that affect nerve function and/or are present in nerve tissue. Research during the last decade has disclosed that many peptide molecules, including the pituitary hormones, are present in the central nervous system, and that they are presumably located in neuronal pathways. They are synthesized in large proteins, and several are formed in the same molecule. A cascade of processes evolve in peptidergic neurons to express the genetic information into biologically active neuropeptides. These processes control the quantities of neuropeptides synthesized as well as the nature of their biological activity through size, form, and derivation of the endproduct. In this way sets of neuropeptides with different, opposite, and more selective properties are formed from the same precursor.

Keywords

Depressed Patient Affective Disorder Pituitary Hormone Thyrotropin Release Hormone Retrograde Amnesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    De Wied D. Effects of peptide hormones on behavior. In Ganong WF, Martini L (eds): Frontiers in Neuroendocrinology. New York: Oxford University Press, 1969; 97–140.Google Scholar
  2. 2.
    De Wied D, Jolles J. Neuropeptides derived from pro-opiocortin: behavioral, physiological and neurochemical effects. Physiol Rev 1982; 62: 976–1059.PubMedGoogle Scholar
  3. 3.
    Carroll BJ. Dexamethasone suppression test: a review of contemporary confusion. J Clin Psychiatry 1985; 46: 13–24.PubMedGoogle Scholar
  4. 4.
    Loosen PT, Prange AJ Jr. Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review. Am J Psychiatry 1982; 139: 405–416.PubMedGoogle Scholar
  5. 5.
    Willner P. The validity of animal models of depression. Psychopharmacology 1984; 83: 1–16.PubMedCrossRefGoogle Scholar
  6. 6.
    Leonard BE. Pharmacological properties of some “second generation” antidepressant drugs. Neuropharmacology 1980; 19: 1175–1183.PubMedCrossRefGoogle Scholar
  7. 7.
    Van Ree JM, De Wied D. Behavioral effects of endorphins: modulation of opiate reward by neuropeptides related to pro-opiocortin and neurohypophyseal hormones. In Smith JE, Lane JD (eds): The Neurobiology of Opiate Reward Processes. Amsterdam: Elsevier, 1983; 109–145.Google Scholar
  8. 8.
    Van Wolfswinkel L, Seifert WF, Van Ree JM. Long-term changes in self-stimulation threshold by repeated morphine and naloxone treatment. Life Sci 1985; 37: 169–176.PubMedCrossRefGoogle Scholar
  9. 9.
    Ogawa N, Mizuno S, Mori A, et al. Potential antidepressive effects of thyrotropin releasing hormone (TRH) and its analogues. Peptides 1984; 5: 743–746.PubMedCrossRefGoogle Scholar
  10. 10.
    Baltzer V, Weiskrantz L. Antidepressant agents and reversal of diurnal activity cycles in the rat. Biol Psychiatry 1973; 10: 199–209.Google Scholar
  11. 11.
    Fekete M, Van Ree JM, De Wied D. The ACTH-(4-9) analog ORG 2766 and desglycinamide9-(Arg;8)-vasopressin reverse the retrograde amnesia induced by disrupting circadian rhythms in rats. Peptides 1986; 7: 563–568.PubMedCrossRefGoogle Scholar
  12. 12.
    Niesink RJM, Van Ree JM. Antidepressant drugs normalize the increased social behavior of pairs of male rats induced by short term isolation. Neuropharmacology 1982; 21: 1343–1348.PubMedCrossRefGoogle Scholar
  13. 13.
    Niesink RJM, Van Ree JM. Neuropeptides and social behavior of rats tested in dyadic encounters. Neuropeptides 1984; 4: 483–496.PubMedCrossRefGoogle Scholar
  14. 14.
    Gaffori O, Van Ree JM. Serotonin and antidepressant drugs antagonize melatonin-induced behavioural changes after injection into the nucleus accumbens of rats. Neuropharmacology 1985; 24: 237–244.PubMedCrossRefGoogle Scholar
  15. 15.
    Gaffori O, Van Ree JM. β-Endorphin-(10-16) antagonizes behavioral responses elicited by melatonin following injection into the nucleus accumbens of rats. Life Sci 1985; 37: 357–364.PubMedCrossRefGoogle Scholar
  16. 16.
    Prange AJ Jr. Garbutt JC, Loosen PT, et al. The role of peptides in affective disorders: a review. Prog Brain Res 1987; 572: 235–247.CrossRefGoogle Scholar
  17. 17.
    Prange AJ Jr, Loosen PT. Peptides in depression. In Usdin E, Asberg M, Bertilsson L, et al. (eds): Frontiers in Biochemical and Pharmacological Research in Depression. New York: Raven Press, 1984; 127–145.Google Scholar
  18. 18.
    Van Ree JM, Verhoeven WMA, Claas FHJ, et al. Antipsychotic action of γ-type endorphins: animal and human studies. Prog Brain Res 1986; 65: 221–235.PubMedCrossRefGoogle Scholar
  19. 19.
    Chazot G, Claustrat B, Brun J, et al. Rapid antidepressant activity of Des Tyr gamma endorphin: correlation with urinary melatonin. Biol Psychiatry 1985; 20: 1026–1030.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Jan M. Van Ree
  • David De Wied

There are no affiliations available

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