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Calcitonin and Calcitonin Gene-Related Peptide

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Neuropeptides and Stress

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HANS SELYE SYMP))

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Abstract

The Ca++ ion plays a critical role in neuronal transmission. Therefore, agents capable of modulating it can exert profound effects on the cell’s ability to interpret extracellular signals. In 1964, Hano et al.1 reported that intracisternal Ca++ administration antagonized the action of morphine, which, conversely, was potentiated by the Ca++ chelator EDTA. This early work was subsequently confirmed by Kakunaga et al.2, Harris et al.3, and Munoz and Fearon4, who introduced Ca++ intraventricularly (icv) or into the periaqueductal gray area (PAG). Mg++ and Mn++ were also found to act as opiate antagonists3, whereas the Ca++-specific chelator EGTA was demonstrated to potentiate morphine’s effect. Other investigations revealed that Ca++, Mg++ and Mn++ antagonized acetylcholine-induced antinociception5, but it was also noted that Ca++, but not Mg++ or Mn++, blocked the antinociception evoked by morphine6. Some of these authors were in agreement that ionophores (X-537A or A23187), which facilitate Ca++ uptake by the cell, enhanced the antagonistic effects of low concentrations of Ca++ on antinociceptive responses to morphine. Since ionophores mostly increase intracellular calcium7, it was postulated that the antagonism of morphine was due to alterations in intracellular events elicited by Ca++8.

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Authors
  1. Sandra P. Welch
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  2. William L. Dewey
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Editor information

Editors and Affiliations

  1. Department of Medicine, Los Angeles School of Medicine, University of California, Los Angeles, California, 90073, USA

    Yvette Taché Ph.D. (Professor and Member) (Professor and Member)

  2. Brain Research Institute, Los Angeles, California, 90024, USA

    Yvette Taché Ph.D. (Professor and Member) & John E. Morley M.D. (Director, Professor and Member) (Professor and Member) &  (Director, Professor and Member)

  3. Geriatric Research, Education, and Clinical Center, Sepulveda Veterans Administration Medical Center, Sepulveda, California, 91343, USA

    John E. Morley M.D. (Director, Professor and Member) (Director, Professor and Member)

  4. Department of Medicine, Los Angeles, School of Medicine, University of California, Los Angeles, California, 90024, USA

    John E. Morley M.D. (Director, Professor and Member) (Director, Professor and Member)

  5. Autonomic Physiology Laboratory, Departments of Medicine and Surgery, San Diego Medical Center, University of California, San Diego, California, 92103, USA

    Marvin R. Brown M.D. (Professor) (Professor)

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© 1989 Springer-Verlag New York Inc.

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Welch, S.P., Dewey, W.L. (1989). Calcitonin and Calcitonin Gene-Related Peptide. In: Taché, Y., Morley, J.E., Brown, M.R. (eds) Neuropeptides and Stress. Hans Selye Symposia on Neuroendocrinology and Stress. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3514-9_17

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  • DOI: https://doi.org/10.1007/978-1-4612-3514-9_17

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8135-1

  • Online ISBN: 978-1-4612-3514-9

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