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Immunity in Tuberculosis: Environmental Versus Intrinsic Factors Modulating the Immune Responsiveness to Mycobacteria

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Progress in Vaccinology

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 2))

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Abstract

Infections caused by mycobacteria produce a wide range of immunological reactions. Tuberculosis and leprosy are often considered the prototype of chronic intracellular infections, and the immunological investigation of these diseases has provided insights into the basic mechanisms of both cellular and humoral immunity (30). However, there are few diseases that so effectively express the spectrum of immune responsiveness as leprosy and, to a lesser extent, tuberculosis. Moreover, results from many BCG vaccine trials against tuberculosis and leprosy showed wide variations in protection (8). Two main hypotheses were put forward to explain the observed variations in the efficacy of vaccination: (a) variability in the potency of the strain and preparations used; and (b) the influence of previous sensitization with atypical mycobacteria. These hypotheses are favored no more, however and it is thought that the protective effect of BCG may depend on epidemiological, environment, and immunological factors affecting the infecting agents as well as the host.

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Authors
  1. P. H. Lagrange
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  2. B. Hurtrel
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Editor information

Editors and Affiliations

  1. National Institute of Immunology, JNU Complex, Shahid Jeet Singh Marg, 110 067, New Delhi, India

    G. P. Talwar

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© 1989 Springer-Verlag New York Inc

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Lagrange, P.H., Hurtrel, B. (1989). Immunity in Tuberculosis: Environmental Versus Intrinsic Factors Modulating the Immune Responsiveness to Mycobacteria. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_7

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  • DOI: https://doi.org/10.1007/978-1-4612-3508-8_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96734-9

  • Online ISBN: 978-1-4612-3508-8

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