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Mycobacterium w: Candidate Vaccine Against Leprosy with Antigens CrossReactive with Three Major Protein Antigens of Mycobacterium leprae

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Progress in Vaccinology

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 2))

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Abstract

Leprosy is a chronic mycobacterial infection caused by Mycobacterium leprae. There are about 15 million people in the world suffering from this disabilitating disease. Although M. leprae was among the first organisms discovered to be associated with a human disease, it has not yet been cultivated on synthetic media in vitro. The growth of M. leprae in nine-banded armadillos for the first time provided enough bacilli for immunological and biochemical studies. Vaccination with purified killed M. leprae obtained from infected armadillo tissues induces long-lasting cell mediated immunity (CMI) in mice (37), guinea pigs (20), and humans (6,7). Immunization of mice with killed M. leprae protects them against viable challenge in the footpads (38).

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Authors
  1. Abu Salim Mustafa
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Editors and Affiliations

  1. National Institute of Immunology, JNU Complex, Shahid Jeet Singh Marg, 110 067, New Delhi, India

    G. P. Talwar

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© 1989 Springer-Verlag New York Inc.

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Mustafa, A.S. (1989). Mycobacterium w: Candidate Vaccine Against Leprosy with Antigens CrossReactive with Three Major Protein Antigens of Mycobacterium leprae . In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_30

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  • DOI: https://doi.org/10.1007/978-1-4612-3508-8_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96734-9

  • Online ISBN: 978-1-4612-3508-8

  • eBook Packages: Springer Book Archive

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