Abstract
Shigellosis (bacillary dysentery) is endemic throughout the world. Because the infectious dose is low (ten organisms), the disease can be spread not only by infected food or water but also by person-to-person contact. Shigellosis is of special concern in developing countries where conditions of sanitation are poor, personal hygiene practices often primitive, and malnutrition common. In endemic areas shigellosis is a disease of childhood. The incidence is low in breast-fed infants, but in weaned infants it may reach a peak of 200,000 cases per 100,000 population per year. In contrast, the incidence of disease in industrialized nations is low (50 cases per 100,000 population per year). The severity of illness may vary from mild diarrhea to severe dysentery (stools of small volume that contain blood, mucous, and inflammatory cells). In extreme cases, which occur most commonly in children, shigellosis can result in hypotensive shock and death. Inflammation and ulcerative lesions of the colon occur in moderate and severe cases. Other signs of illness include fever, cramps, and te-nesmus.
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Formal, S.B., Hale, T.L., Kapfer, C. (1989). Shigella Vaccines. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_19
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DOI: https://doi.org/10.1007/978-1-4612-3508-8_19
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