Abstract
Epidemic and endemic cholera in humans is caused by Vibrio cholerae 01. Infection occurs through the oral route by ingestion of contaminated food and water. If vibrios successfully escape the acidic environment of the stomach, they arrive in the small intestine, where a series of pathogenic events occur that result in colonization of vibrios and release of cholera toxin. The net result is the onset of diarrhea and associated clinical symptoms of cholera.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bhattachaijee JW, Srivastava BS: Adherence of the wild type and mutant strains of Vibrio cholerae to normal and immune intestinal tissues. Bull WHO 1979; 87: 123–128.
De SN, Chatteiji DN: An experimental study of the mechanism of action of Vibrio cholerae on the intestinal mucous membrane. J Pathol Bacteriol 1953; 66: 559–567.
Freter F, Jones DW: Adhesive properties of Vibrio cholerae: nature of the interaction with intact mucosal surfaces. Infect Immun 1976; 14: 246–256.
Guentzel MN, Berry LJ: Motility as a virulence factor for Vibrio cholerae. Infect Immun 1975; 11: 890–897.
Jacob A, Sahib MK, Sinha VB, Srivastava BS: Adhesive antigens of Vibrio cholerae. II. Isolation and characterization of a 22 KDal protein. Submitted for publication.
Jacob A, Sinha VB, Srivastava BS: Adhesive antigens of Vibrio cholerae. I. Antibodies inhibiting bacterial adherence. Submitted for publication.
Levine MM, Kaper JB, Black RB, Clements ML: New knowledge on path-ogenesis of bacterial enteric infections as applied to vaccine development. Microbiol Rev 1983; 47: 510–550.
Manning PA, Bartowsky EJ, Leavesly DI, et al: Molecular cloning using im-mune sera of a 22 KDal minor outer membrane protein of Vibrio cholerae. Gene 1985; 34: 95–103.
Nelson ET, Clements JD, Finkelstein RA: Vibrio cholerae adherence and col-onization in experimental cholera: electron microscopic studies. Infect Immun 1976; 14: 527–547.
Peterson JW, Hejtmancik KE, Markel DE, et al: Antigenic specificity of neu¬tralizing antibody to cholera toxin. Infect Immun 1979;24:774–779
Schrank GD, Verwey WF: Distribution of cholera organisms in experimental Vibrio cholerae infections: proposed mechanism of pathogenesis and anti-bacterial immunity. Infect Immun 1976; 13: 195–203
Srivastava R, Sinha VB, Srivastava BS: Re-evaluation of antibacterial and antitoxin immunities in experimental cholera. Indian J Med Res 1979;70:369–373
Srivastava R, Srivastava BS: Isolation of a non-adhesive mutant of Vibrio cholerae and chromosomal localization of the gene controlling mannose-sen- sitive adherence. J Gen Microbiol 1980; 117: 275–278.
Srivastava R, Sinha VB, Srivastava BS: Events in the pathogenesis of ex-perimental cholera: role of bacterial adherence and multiplication. J Med Mi-crobiol 1980; 13: 1–9.
Srivastava R, Khan AA, Srivastava BS: Immunological detection of cloned antigenic genes of Vibrio cholerae in Escherichia coli. Gene 1985; 40: 267–272.
Svennerholm AM, Holmgren J: Synergistic protective effect in rabbits of im¬munization with Vibrio cholerae lipopolysaccharide and toxin/toxoid. Infect Immun 1976; 13: 735–740.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag New York Inc.
About this paper
Cite this paper
Srivastava, B.S., Srivastava, R., Jacob, A. (1989). Prospects of Immunization Against Cholera by Adhesive Antigen. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_15
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3508-8_15
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-96734-9
Online ISBN: 978-1-4612-3508-8
eBook Packages: Springer Book Archive