Intracellular Mechanisms in GH Control

  • G. Schettini
  • T. Florio
  • O. Meucci
  • E. Landolfi
  • M. Grimaldi
  • G. Magri
  • B. Merola
  • G. Lombardi
Conference paper
Part of the Neuroendocrine Perspectives book series (NEUROENDOCRINE, volume 6)


The neuroendocrine regulation of GH secretion involves two major factors of hypothalamic origin: the recently isolated GH releasing hormone (GRF) and the inhibitory factor somatostatin (SRIF) (1–5). After having been secreted into the hypophyseal portal blood, these factors reach the anterior pituitary gland, where they interact with specific receptors (probably located on somatotrophs), thus eliciting physiological responses.


Growth Hormone Pertussis Toxin Anterior Pituitary Cell Pituitary Growth Hormone Growth Hormone Release Factor 
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • G. Schettini
    • 1
  • T. Florio
    • 1
  • O. Meucci
    • 1
  • E. Landolfi
    • 1
  • M. Grimaldi
    • 1
  • G. Magri
    • 1
  • B. Merola
    • 2
  • G. Lombardi
    • 2
  1. 1.Department of PharmacologyII School of Medicine, University of NaplesNaplesItaly
  2. 2.Department of EndocrinologyII School of Medicine, University of NaplesNaplesItaly

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